Data-Driven Design of PROTAC Linkers to Improve PROTAC Cell Membrane Permeability. [PDF]
JACS AuProteolysis-targeting chimeras (PROTACs) are promising next-generation therapeutics for the degradation of disease-associated proteins. However, optimizing the physicochemical properties of PROTACs, particularly their poor cell membrane permeability ...
Murakami Y +7 more
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Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation
Advanced Science, 2021 Hydrodynamic force loading platforms for controllable cell mechanical deformation play an essential role in modern cell technologies. Current systems require assistance from specific microstructures thus limiting the controllability and flexibility in ...
Xinyi Guo +9 more
doaj +3 more sources
Macrocyclic Peptides Closed by a Thioether-Bipyridyl Unit That Grants Cell Membrane Permeability. [PDF]
ACS Bio Med Chem Au, 2023 Membrane permeability is an important factor that determines the virtue of peptides targeting intracellular molecules. By introducing a membrane penetration motif, some peptides exhibit better membrane permeabilities.
Chen H, Katoh T, Suga H.
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Cold Atmospheric Plasma Treatment of Chondrosarcoma Cells Affects Proliferation and Cell Membrane Permeability. [PDF]
Int J Mol Sci, 2020 Chondrosarcoma is the second most common malign bone tumor in adults. Surgical resection of the tumor is recommended because of its resistance to clinical treatment such as chemotherapy and radiation therapy.
Haralambiev L +7 more
europepmc +2 more sources
Mode of action of the antimicrobial peptide Mel4 is independent of Staphylococcus aureus cell membrane permeability. [PDF]
PLoS One, 2019 Mel4 is a novel cationic peptide with potent activity against Gram-positive bacteria. The current study examined the anti-staphylococcal mechanism of action of Mel4 and its precursor peptide melimine.
Yasir M, Dutta D, Willcox MDP.
europepmc +2 more sources
The Antifungal Peptide MCh-AMP1 Derived From Matricaria chamomilla Inhibits Candida albicans Growth via Inducing ROS Generation and Altering Fungal Cell Membrane Permeability. [PDF]
Front Microbiol, 2019 The rise of antifungal drug resistance in Candida species responsible for life threatening candidiasis is considered as an increasing challenge for the public health. MCh-AMP1 has previously been reported as a natural peptide from Matricaria chamomilla L.
Seyedjavadi SS +10 more
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A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability. [PDF]
Lab Chip, 2017 Semi- and selective permeability is a fundamentally important characteristic of the cell membrane. Membrane permeability can be determined by monitoring the volumetric change of cells following exposure to a non-isotonic environment.
Weng L +7 more
europepmc +2 more sources
Characterization of Cell Membrane Permeability In Vitro Part II: Computational Model of Electroporation-Mediated Membrane Transport. [PDF]
Technol Cancer Res Treat, 2018 Electroporation is the process by which applied electric fields generate nanoscale defects in biological membranes to more efficiently deliver drugs and other small molecules into the cells.
Sweeney DC, Douglas TA, Davalos RV.
europepmc +2 more sources
Journal of Pharmaceutical Analysis, 2019 The aim of this study was to investigate antibacterial activity of Origanum compactum essential oils collected at three phenological stages on Escherichia coli and Bacillus subtilis.
Abdelhakim Bouyahya +3 more
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Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
eLife, 2017 Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are also needed for mitochondrial-dependent cellular necrosis (Karch et al., 2013 ...
Jason Karch +6 more
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