Results 1 to 10 of about 20,118 (118)
Cell Reports, 2016 We investigated early phenotypes caused by familial Alzheimer’s disease (fAD) mutations in isogenic human iPSC-derived neurons. Analysis of neurons carrying fAD PS1 or APP mutations introduced using genome editing technology at the endogenous loci ...
Rik van der Kant +2 more
exaly +3 more sources
Application of In vitro transcytosis models to brain targeted biologics.
PLoS ONE, 2023 The blood brain barrier (BBB) efficiently limits the penetration of biologics drugs from blood to brain. Establishment of an in vitro BBB model can facilitate screening of central nervous system (CNS) drug candidates and accelerate CNS drug development ...
Kangwen Deng +6 more
doaj +2 more sources
Unraveling GLUT‐mediated transcytosis pathway of glycosylated nanodisks
Asian Journal of Pharmaceutical Sciences, 2021 Glucose transporter (GLUT)-mediated transcytosis has been validated as an efficient method to cross the blood-brain barrier and enhance brain transport of nanomedicines. However, the transcytosis process remains elusive.
Huan Wang +4 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2023 Extracellular vesicles (EVs) have recently received much attention about the application of drug carriers due to their desirable properties such as nano-size, biocompatibility, and high stability.
Feng Long +11 more
doaj +1 more source
Molecular Medicine, 2023 Objective To elucidate the mechanism whereby advanced glycation end products (AGEs) accelerate atherosclerosis (AS) and to explore novel therapeutic strategies for atherosclerotic cardiovascular disease.
Meng Shu +11 more
doaj +1 more source
BAAV transcytosis requires an interaction with beta-1-4 linked- glucosamine and gp96. [PDF]
PLoS ONE, 2010 Cell surface carbohydrates play an important role in virus entry and intracellular trafficking. Bovine Adeno-Associated Virus (BAAV) uses plasma membrane gangliosides for transduction and infection.
Giovanni Di Pasquale +3 more
doaj +1 more source
A New Pathogenesis of Albuminuria: Role of Transcytosis
Cellular Physiology and Biochemistry, 2018 Transcytosis is an important intracellular transport process by which multicellular organisms selectively move cargoes from apical to basolateral membranes without disrupting cellular homeostasis.
Fang-Fang He +7 more
doaj +1 more source
Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays
Fluids and Barriers of the CNS, 2021 Background The pathways that control protein transport across the blood–brain barrier (BBB) remain poorly characterized. Despite great advances in recapitulating the human BBB in vitro, current models are not suitable for systematic analysis of the ...
Claire Simonneau +10 more
doaj +1 more source
Sorting Tubules Regulate Blood-Brain Barrier Transcytosis
Cell Reports, 2017 Transcytosis across the blood-brain barrier (BBB) regulates key processes of the brain, but the intracellular sorting mechanisms that determine successful receptor-mediated transcytosis in brain endothelial cells (BECs) remain unidentified. Here, we used
Roberto Villaseñor +4 more
doaj +1 more source
STAR Protocols, 2023 Summary: Transcytosis is the primary mechanism by which macro-molecules transverse epithelial cell barriers. Here, we present an assay for measuring transcytosis and recycling of IgG in intestinal epithelial Caco-2 cells and primary human intestinal ...
Keiko Maeda +4 more
doaj +1 more source