Results 1 to 10 of about 37,961 (284)
Acta Pharmaceutica Sinica B, 2023 Extracellular vesicles (EVs) have recently received much attention about the application of drug carriers due to their desirable properties such as nano-size, biocompatibility, and high stability.
Feng Long +11 more
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Molecular Medicine, 2023 Objective To elucidate the mechanism whereby advanced glycation end products (AGEs) accelerate atherosclerosis (AS) and to explore novel therapeutic strategies for atherosclerotic cardiovascular disease.
Meng Shu +11 more
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The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells. [PDF]
PLoS Pathogens, 2013 The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody.
Sandeep Gupta +18 more
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Strategies to Screen and Evaluate Brain Targeting Antibodies Using an iPSC-Derived Blood–Brain Barrier Model [PDF]
AntibodiesBackground: Antibodies that cross the blood–brain barrier (BBB) by targeting receptor-mediated transport (RMT) systems can allow efficient drug delivery to the central nervous system (CNS).
Eun Seo Choi +4 more
doaj +2 more sources
LDL transcytosis passes through the trans-Golgi network and requires Rab10 [PDF]
Journal of Lipid ResearchAtherosclerosis begins with the subendothelial retention of LDLs from the circulation. While LDL transcytosis across the endothelium is mediated by scavenger receptor class B type I and activin-like kinase receptor 1 and is usually independent of LDL ...
Tse Wing Winnie Ho +2 more
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Cell Reports, 2016 We investigated early phenotypes caused by familial Alzheimer’s disease (fAD) mutations in isogenic human iPSC-derived neurons. Analysis of neurons carrying fAD PS1 or APP mutations introduced using genome editing technology at the endogenous loci ...
Grace Woodruff +2 more
exaly +3 more sources
Application of In vitro transcytosis models to brain targeted biologics.
PLoS ONE, 2023 The blood brain barrier (BBB) efficiently limits the penetration of biologics drugs from blood to brain. Establishment of an in vitro BBB model can facilitate screening of central nervous system (CNS) drug candidates and accelerate CNS drug development ...
Kangwen Deng +6 more
doaj +2 more sources
Unraveling GLUT‐mediated transcytosis pathway of glycosylated nanodisks
Asian Journal of Pharmaceutical Sciences, 2021 Glucose transporter (GLUT)-mediated transcytosis has been validated as an efficient method to cross the blood-brain barrier and enhance brain transport of nanomedicines. However, the transcytosis process remains elusive.
Huan Wang +4 more
doaj +1 more source
BAAV transcytosis requires an interaction with beta-1-4 linked- glucosamine and gp96. [PDF]
PLoS ONE, 2010 Cell surface carbohydrates play an important role in virus entry and intracellular trafficking. Bovine Adeno-Associated Virus (BAAV) uses plasma membrane gangliosides for transduction and infection.
Giovanni Di Pasquale +3 more
doaj +1 more source
A New Pathogenesis of Albuminuria: Role of Transcytosis
Cellular Physiology and Biochemistry, 2018 Transcytosis is an important intracellular transport process by which multicellular organisms selectively move cargoes from apical to basolateral membranes without disrupting cellular homeostasis.
Fang-Fang He +7 more
doaj +1 more source