Results 31 to 40 of about 37,961 (284)

Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier [PDF]

, 2016
According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor-related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-beta (A beta) brain accumulation and drives ...
Alessandro Di Spiezio, Axel Heimann, Bell, Bouter, Bu, Carsten Korth, Claus U. Pietrzik, Deane, Deane, Dodart, Hahn, Heyser, Ingrid Prikulis, Ito, Ito, Ito, Julius N. Meißner, Julius Nahrath, Kanekiyo, Korth, Leneuve, Markus Schwaninger, Mc Donald, Nils Schubert, Qosa, Roosmarijn E. Vandenbroucke, Sabrina Meister, Sandra Baches, Sascha Weggen, Steffen E. Storck, Thomas A. Bayer, Tooyama, Tooyama, Wolf, Yvonne Bouter   +34 more
core   +2 more sources

A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies

Cellular and molecular neurobiology, 2023
Delivering biologics to elicit a therapeutic response in the central nervous system (CNS) remains challenging due to the presence of the blood – brain barrier (BBB).
F. Burgio, C. Gaiser, Kevin Brady, Viviana Gatta, R. Class, R. Schrage, L. Suter-Dick   +6 more
semanticscholar   +1 more source

Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus. [PDF]

, 2019
Though congenital hydrocephalus is heritable, it has been linked only to eight genes, one of which is MPDZ Humans and mice that carry a truncated version of MPDZ incur severe hydrocephalus resulting in acute morbidity and lethality.
Byrne, Matthew D., Horowitz, Arie, Ishikawa, Hiroshi, Kilker, Robert, Londin, Eric, Nichtova, Zuzana, Oakley, Laura, Pardeep-Kumar, Fnu, Pickup, Stephen, Saugier-Veber, Pascale, Schroten, Horst, Simonneau, Claire, Smeyne, Richard, Stefanescu, Ioana, Thakur, Mathew, Tripathi, Sushil, Willard, Belinda, Yang, Junning   +17 more
core   +2 more sources

The Role of BAR Proteins and the Glycocalyx in Brain Endothelium Transcytosis

Cells, 2020
Within the brain, endothelial cells lining the blood vessels meticulously coordinate the transport of nutrients, energy metabolites and other macromolecules essential in maintaining an appropriate activity of the brain.
Diana M. Leite, Diana Matias, Giuseppe Battaglia   +2 more
doaj   +1 more source

Cronobacter sakazakii ATCC 29544 Translocated Human Brain Microvascular Endothelial Cells via Endocytosis, Apoptosis Induction, and Disruption of Tight Junction

Frontiers in Microbiology, 2021
Cronobacter sakazakii (C. sakazakii) is an emerging opportunistic foodborne pathogen that can cause neonatal necrotizing enterocolitis, meningitis, sepsis in neonates and infants with a relatively high mortality rate.
Tong Jin, Ning Guan, Yuhang Du, Xinpeng Zhang, Jiahui Li, Xiaodong Xia, Xiaodong Xia   +6 more
doaj   +1 more source

Tumor-Derived Extracellular Vesicles Breach the Intact Blood Brain Barrier via Transcytosis.

ACS Nano, 2019
The restrictive nature of the blood brain barrier (BBB) creates a major challenge for brain drug delivery with current nanomedicines lacking the ability to cross the BBB.
Golnaz Morad, C. Carman, Elliott J. Hagedorn, J. Perlin, L. Zon, N. Mustafaoglu, Tae-Eun Park, D. Ingber, Cassandra C. Daisy, M. Moses   +9 more
semanticscholar   +1 more source

Inflammatory Cell–Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis

Arteriosclerosis, Thrombosis and Vascular Biology, 2023
BACKGROUND: Inflammation contributes to the pathogenesis of atherosclerosis. But little is known about the potential benefits of inflammatory cells to atherosclerosis.
Jinling Xu, Huaxing Ma, Lingfeng Shi, Hui Zhou, Yangyang Cheng, Jiayue Tong, Biying Meng, Xiaoli Xu, Kaiyue He, Sheng Ding, Jiajia Zhang, Ling Yue, G. Xiang   +12 more
semanticscholar   +1 more source

Overview of Crosstalk Between Multiple Factor of Transcytosis in Blood Brain Barrier

Frontiers in Neuroscience, 2020
Blood brain barrier (BBB) conserves unique regulatory system to maintain barrier tightness while allowing adequate transport between neurovascular units.
Marco Tjakra, Yeqi Wang, Vicki Vania, Zhengjun Hou, Colm Durkan, Nan Wang, Guixue Wang   +6 more
doaj   +1 more source

FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function

Frontiers in Systems Neuroscience, 2023
Sleep and circadian rhythms are observed broadly throughout animal phyla and influence neural plasticity and cognitive function. However, the few phylogenetically conserved cellular and molecular pathways that are implicated in these processes are ...
Jason R. Gerstner, Jason R. Gerstner, Jason R. Gerstner, Carlos C. Flores, Micah Lefton, Brooke Rogers, Christopher J. Davis, Christopher J. Davis, Christopher J. Davis   +8 more
doaj   +1 more source

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. [PDF]

, 2015
Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease.
Goldstein, Lawrence SB, Niederst, Emily D, Reyna, Sol M   +2 more
core   +1 more source