Results 11 to 20 of about 37,961 (284)
Sorting Tubules Regulate Blood-Brain Barrier Transcytosis [PDF]
Cell Reports, 2017 Transcytosis across the blood-brain barrier (BBB) regulates key processes of the brain, but the intracellular sorting mechanisms that determine successful receptor-mediated transcytosis in brain endothelial cells (BECs) remain unidentified. Here, we used
Roberto Villaseñor +4 more
doaj +4 more sources
Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays
Fluids and Barriers of the CNS, 2021 Background The pathways that control protein transport across the blood–brain barrier (BBB) remain poorly characterized. Despite great advances in recapitulating the human BBB in vitro, current models are not suitable for systematic analysis of the ...
Claire Simonneau +10 more
doaj +2 more sources
Transcytosis at the blood-brain barrier.
Current Opinion in Neurobiology, 2019 The blood-brain barrier (BBB) is a functional interface separating the brain from the circulatory system and is essential for homeostasis of the central nervous system (CNS).
S. Ayloo, Chenghua Gu
semanticscholar +4 more sources
PLoS ONE, 2014 We have adapted an in vitro model of the human blood-brain barrier, the immortalized human cerebral microvascular endothelial cells (hCMEC/D3), to quantitatively measure protein transcytosis.
Hadassah Sade +5 more
doaj +3 more sources
Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers
mBio, 2017 Bacterial viruses are among the most numerous biological entities within the human body. These viruses are found within regions of the body that have conventionally been considered sterile, including the blood, lymph, and organs.
Sophie Nguyen +13 more
doaj +2 more sources
Nature Materials, 2023 Targeting of tumour vasculature endothelial P-selectin promotes caveolin-1-mediated transcytosis for enhanced blood–brain barrier crossing of therapeutic nanoparticles against medulloblastoma. Medulloblastoma is the most common malignant paediatric brain
Daniel E Tylawsky +12 more
semanticscholar +1 more source
International Journal of Oral Science, 2023 Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer’s disease (AD). The blood-brain barrier
S. Lei +8 more
semanticscholar +1 more source
IgA transcytosis and antigen recognition govern ovarian cancer immunity
Nature, 2021 Most ovarian cancers are infiltrated by prognostically relevant activated T cells1–3, yet exhibit low response rates to immune checkpoint inhibitors4.
Subir Biswas +22 more
semanticscholar +1 more source
KIF16B delivers for transcytosis [PDF]
The EMBO Journal, 2013 Protein sorting pathways control correct delivery of membrane proteins to specific compartments of the plasma membrane and are required to maintain the physiological functions in all epithelia. Most clathrin‐dependent cargoes require the adaptor protein complexes AP‐1A and AP‐1B for proper sorting to the basolateral plasma membrane.
Alejo E, Rodríguez-Fraticelli +2 more
openaire +2 more sources
Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice
Nature Cardiovascular Research, 2023 Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis initiation and progression1. Activin A receptor-like type 1 (ACVRL1, called activin-like kinase receptor (ALK1)) is a recently identified receptor that ...
Sungwoon Lee +21 more
semanticscholar +1 more source