Results 21 to 30 of about 23,538 (242)

KIF16B delivers for transcytosis [PDF]

The EMBO Journal, 2013
Protein sorting pathways control correct delivery of membrane proteins to specific compartments of the plasma membrane and are required to maintain the physiological functions in all epithelia. Most clathrin‐dependent cargoes require the adaptor protein complexes AP‐1A and AP‐1B for proper sorting to the basolateral plasma membrane.
Alejo E, Rodríguez-Fraticelli, Manuel, Galvez-Santisteban, Fernando, Martin-Belmonte   +2 more
openaire   +2 more sources

Endocytosis and transcytosis of gliadin peptides [PDF]

Molecular and Cellular Pediatrics, 2016
Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have different biological effects. Gliadin peptides can induce innate and adaptive T cell-mediated immune responses.
Barone, M Vittoria, Zimmer, K Peter
openaire   +3 more sources

Transepithelial Secretion of Mucosal IgM Mediated by Polymeric Immunoglobulin Receptor of Flounder (Paralichthys olivaceus): In-Vivo and In-Vitro Evidence

Frontiers in Immunology, 2022
Secretory immunoglobulin (SIg) is crucial for mucosal surface defenses, but the transepithelial secretion of SIg mediated by polymeric immunoglobulin receptor (pIgR) is not clarified in fish.
Xiuzhen Sheng, Xiuzhen Sheng, Yuan Guo, Hui Zhu, Baihui Chai, Xiaoqian Tang, Xiaoqian Tang, Jing Xing, Jing Xing, Heng Chi, Heng Chi, Wenbin Zhan, Wenbin Zhan   +12 more
doaj   +1 more source

Hyperglycemia-Induced Microglial CTSS Disrupts Blood-Retinal Barrier Integrity via PAR2-Dependent Downregulation of Endothelial MFSD2A. [PDF]

CNS Neurosci Ther
Hyperglycemia induces retinal microglial activation and CTSS upregulation, disrupting microglia‐endothelial crosstalk via PAR2‐dependent MFSD2A suppression. Abnormal activation of microglia amplifies retinal inflammatory cascade, enhances transcytosis, compromises BRB integrity, and accelerates DR progression.
Xu C, Li H, Xu Q, Zhao K, Chen Y, Wang Y, Zou W, Kuang B, Kuang H.   +8 more
europepmc   +2 more sources

Colostrogenesis: candidate genes for IgG1 transcytosis mechanisms in primary bovine mammary epithelial cells. [PDF]

, 2013
Bovine colostrogenesis is distinguished by the specific transfer of IgG1 from the blood to mammary secretions. The process has been shown to be initiated by hormones and occurs during the last weeks of pregnancy when steroid concentrations of estradiol ...
Bruckmaier, Rupert M., Wellnitz, Olga, Stark, A, Stark, Andrea, Baumrucker, C, Wellnitz, O, Vachkova, E, Baumrucker, C., Vachkova, E., Bruckmaier, R M   +9 more
core   +1 more source

Transportation of Single-Domain Antibodies through the Blood–Brain Barrier

Biomolecules, 2021
Single-domain antibodies derive from the heavy-chain-only antibodies of Camelidae (camel, dromedary, llama, alpaca, vicuñas, and guananos; i.e., nanobodies) and cartilaginous fishes (i.e., VNARs).
Eduardo Ruiz-López, Alberto J. Schuhmacher   +1 more
doaj   +1 more source

The Formin INF2 Regulates Basolateral-to-Apical Transcytosis and Lumen Formation in Association with Cdc42 and MAL2 [PDF]

, 2010
SummaryTranscytosis is a widespread pathway for apical targeting in epithelial cells. MAL2, an essential protein of the machinery for apical transcytosis, functions by shuttling in vesicular carriers between the apical zone and the cell periphery.
Aranda, Juan F., Jiménez, Alberto, Andrés Delgado, Laura, Rodríguez-Fraticelli, Alejo E., Alonso, Miguel, Fanayan, Susan, Madrid, Ricardo, Aranda Gómez, Juan Francisco, Madrid González, Ricardo, Andrés-Delgado, Laura, Alonso, Miguel A., Martín-Belmonte, Fernando, Gómez, Sergio, Shehata, Mona, Byrne, Jennifer A., Rodríguez Fraticelli, Alejo, Martín Belmonte, Fernando, Shahheydari, Hamideh, Ventimiglia, Leandro, Byrne, Jennifer Anne   +19 more
core   +1 more source

Macromolecule Translocation across the Intestinal Mucosa of HIV-Infected Patients by Transcytosis and through Apoptotic Leaks

Cells, 2023
Based on indirect evidence, increased mucosal translocation of gut-derived microbial macromolecules has been proposed as an important pathomechanism in HIV infection. Here, we quantified macromolecule translocation across intestinal mucosa from treatment-
Susanne M. Krug, Carolin Grünhagen, Kristina Allers, Christian Bojarski, Joachim Seybold, Thomas Schneider, Jörg-Dieter Schulzke, Hans-Jörg Epple   +7 more
doaj   +1 more source

Angiopoietin2-mediated caveolin1 phosphorylation regulating transcytosis of renal tubular epithelial cell contributes to the occurrence of albuminuria under high glucose exposure

Journal of Translational Medicine, 2022
Background Microlbuminuria is the earliest clinical evidence of diabetic kidney disease (DKD) and contributes to the induction and/or progression of DKD.
Jing Liu, Junxia Yao, Yi Zhao, Jinxuan Su, Jiajia Ye, Yumei Wang   +5 more
doaj   +1 more source

Cholesterol-sensitive Modulation of Transcytosis [PDF]

Molecular Biology of the Cell, 2007
Cholesterol-rich membrane domains (e.g., lipid rafts) are thought to act as molecular sorting machines, capable of coordinating the organization of signal transduction pathways within limited regions of the plasma membrane and organelles. The significance of these domains in polarized postendocytic sorting is currently not understood.
Julieta, Leyt, Naomi, Melamed-Book, Jean-Pierre, Vaerman, Shulamit, Cohen, Aryeh M, Weiss, Benjamin, Aroeti   +5 more
openaire   +2 more sources