Results 21 to 30 of about 37,961 (284)
Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood–brain barrier
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Pathogenic bacteria can reach the brain to cause meningitis resulting in high mortality and morbidity. The brain is particularly protected and isolated from the rest of the body by the blood–brain barrier (BBB).
Zhihui Cheng +13 more
semanticscholar +1 more source
Cholesterol-sensitive Modulation of Transcytosis [PDF]
Molecular Biology of the Cell, 2007 Cholesterol-rich membrane domains (e.g., lipid rafts) are thought to act as molecular sorting machines, capable of coordinating the organization of signal transduction pathways within limited regions of the plasma membrane and organelles. The significance of these domains in polarized postendocytic sorting is currently not understood.
Leyt, Julieta +5 more
openaire +3 more sources
CNS Delivery Via Adsorptive Transcytosis [PDF]
The AAPS Journal, 2008 Adsorptive-mediated transcytosis (AMT) provides a means for brain delivery of medicines across the blood-brain barrier (BBB). The BBB is readily equipped for the AMT process: it provides both the potential for binding and uptake of cationic molecules to the luminal surface of endothelial cells, and then for exocytosis at the abluminal surface.
Françoise, Hervé +2 more
openaire +2 more sources
STAR Protocols, 2023 Summary: Transcytosis is the primary mechanism by which macro-molecules transverse epithelial cell barriers. Here, we present an assay for measuring transcytosis and recycling of IgG in intestinal epithelial Caco-2 cells and primary human intestinal ...
Keiko Maeda +4 more
doaj +1 more source
Pharmaceutics, 2021 The low permeability of nanoparticles (NPs) across the intestinal epithelium remains a major challenge for their application of delivering macromolecular therapeutic agents via the oral route.
Ruiying Li +5 more
doaj +1 more source
Metabolism: Clinical and Experimental, 2022 BACKGROUND Atherosclerosis (AS) is the basis of diabetic macrovascular complications. The plasma low-density lipoprotein (LDL) particles transcytosis across endothelial cells (ECs) and deposition under the endothelium is the initiation step of AS.
Ying Zhao +13 more
semanticscholar +1 more source
Transcytosis of Staphylococcal Superantigen Toxins [PDF]
The Journal of Experimental Medicine, 1997 Staphylococcus aureus produces a set of proteins (e.g., staphylococcal enterotoxin A [SEA], SEB, toxic shock syndrome toxin 1 [TSST-1]) which act both as superantigens (SAgs) and toxins. Although their mode of action as SAgs is well understood, little is known about how they enter the body via the intestine and cause food poisoning.
A R, Hamad, P, Marrack, J W, Kappler
openaire +2 more sources
Strategies for Targeted Delivery of Exosomes to the Brain: Advantages and Challenges
Pharmaceutics, 2022 Delivering therapeutics to the central nervous system (CNS) is difficult because of the blood–brain barrier (BBB). Therapeutic delivery across the tight junctions of the BBB can be achieved through various endogenous transportation mechanisms.
Hojun Choi +6 more
doaj +1 more source
LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease. [PDF]
, 2019 The low-density lipoprotein receptor-related protein-1 (LRP1) has a dual role in the metabolism of the amyloid precursor protein (APP). In cellular models, LRP1 enhances amyloid-β (Aβ) generation via APP internalization and thus its amyloidogenic ...
Gordts, Philip LSM +7 more
core +3 more sources
Journal of Translational Medicine, 2022 Background Microlbuminuria is the earliest clinical evidence of diabetic kidney disease (DKD) and contributes to the induction and/or progression of DKD.
Jing Liu +5 more
doaj +1 more source