Results 41 to 50 of about 23,538 (242)
Suppression of transcytosis regulates zebrafish blood-brain barrier function
eLife, 2019 As an optically transparent model organism with an endothelial blood-brain barrier (BBB), zebrafish offer a powerful tool to study the vertebrate BBB. However, the precise developmental profile of functional zebrafish BBB acquisition and the subcellular ...
Natasha M O'Brown +2 more
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Host Molecules Regulating Neural Invasion of Zika Virus and Drug Repurposing Strategy
Frontiers in Microbiology, 2022 Zika virus (ZIKV) is a mosquito-borne, single-stranded RNA virus belonging to the genus Flavivirus. Although ZIKV infection is usually known to exhibit mild clinical symptoms, intrauterine ZIKV infections have been associated with severe neurological ...
Li Yin Tan +4 more
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Identification of a Transcytosis Epitope on Staphylococcal Enterotoxins [PDF]
Infection and Immunity, 2002 ABSTRACTStaphylococcal enterotoxins (SE) are exoproteins produced byStaphylococcus aureusthat act as superantigens and have been implicated as a leading cause of food-borne disease and toxic shock. Little is known about how these molecules penetrate the gut lining and gain access to both local and systemic immune tissues.
Jeffrey W, Shupp +2 more
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Transcytosis at the blood–brain barrier
Current Opinion in Neurobiology, 2019 The blood-brain barrier (BBB) is a functional interface separating the brain from the circulatory system and is essential for homeostasis of the central nervous system (CNS). The BBB regulates molecular flux to maintain an optimal environment for neuronal function and protects the brain from toxins and pathogens.
Swathi, Ayloo, Chenghua, Gu
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Identification of a Cytoplasmic Signal for Apical Transcytosis [PDF]
Traffic, 2009 Polarized epithelial cells contain apical and basolateral surfaces with distinct protein compositions. To establish and maintain this asymmetry, newly made plasma membrane proteins are sorted in the trans Golgi network for delivery to apical or basolateral surfaces. Signals for basolateral sorting are generally located in the cytoplasmic domain of the
Frédéric, Luton +3 more
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GRP75 as a functional element of cholix transcytosis
Tissue Barriers, 2022 Cholix (Chx) is secreted by non-pandemic strains of Vibrio cholerae in the intestinal lumen. For this exotoxin to induce cell death in non-polarized cells in the intestinal lamina propria, it must traverse the epithelium in the fully intact form. We identified host cell elements in polarized enterocytes associated with Chx endocytosis and apical to ...
Keyi Liu +8 more
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Macropinocytosis as a potential mechanism driving neurotropism of Cryptococcus neoformans
Frontiers in Cellular and Infection Microbiology, 2023 Cryptococcus neoformans can invade the central nervous system by crossing the blood-brain barrier via a transcellular mechanism that relies on multiple host factors. In this narrative, we review the evidence that a direct interplay between C.
Dylan M. Lanser +3 more
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LDL transcytosis passes through the trans-Golgi network and requires Rab10
Journal of Lipid ResearchAtherosclerosis begins with the subendothelial retention of LDLs from the circulation. While LDL transcytosis across the endothelium is mediated by scavenger receptor class B type I and activin-like kinase receptor 1 and is usually independent of LDL ...
Tse Wing Winnie Ho +2 more
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Frontiers in PharmacologyThe blood-retina barrier (BRB) serves as a critical interface that separates the retina from the circulatory system, playing an essential role in preserving the homeostasis of the microenvironment within the retina.
Chun-Lin Zhang +7 more
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Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor
Cell Reports, 2016 Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and ...
Niloufar Monhasery +13 more
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