Results 51 to 60 of about 37,961 (284)

Morphogen Transport in Epithelia

, 2006
We present a general theoretical framework to discuss mechanisms of morphogen transport and gradient formation in a cell layer. Trafficking events on the cellular scale lead to transport on larger scales. We discuss in particular the case of transcytosis
B. Houchmandzadeh, D. A. Lauffenburger, F. Jülicher, H. Meinhardt, K. Kruse, M. González-Gaitán, P. Pantazis, S. Morimura, T. Bollenbach   +8 more
core   +1 more source

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]

, 2019
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Dobrow, Sebastian, Flores, Claudia, Linden, Jennifer R, Michel, Adam O, Schmidt, Eric F, Uzal, Francisco A, Valenzuela, Marissa, Vartanian, Timothy   +7 more
core   +1 more source

Mechanisms of receptor-mediated transcytosis at the blood-brain barrier.

Journal of Controlled Release
In receptor-mediated transcytosis (RMT) of large therapeutics across the blood-brain barrier (BBB), the construct - a macromolecule or a larger carrier with therapeutic payload - binds a protein on brain capillary endothelial cells (BCEC), with ...
Habib Baghirov
semanticscholar   +1 more source

The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals

Frontiers in Immunology, 2020
The gut is an efficient barrier which protects against the passage of pathogenic microorganisms and potential harmful macromolecules into the body, in addition to its primary function of nutrient digestion and absorption.
Björn Weström, Ester Arévalo Sureda, Kateryna Pierzynowska, Kateryna Pierzynowska, Stefan G. Pierzynowski, Stefan G. Pierzynowski, Francisco-José Pérez-Cano, Francisco-José Pérez-Cano   +7 more
doaj   +1 more source

Robust formation of morphogen gradients

, 2004
We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from binding of ligands to
A. Eldar, A. Gierer, A. D. Lander, A. M. Turing, D. A. Lauffenburger, E. V. Entchev, F. Crick, F. Jülicher, K. Kruse, L. Wolpert, M. González-Gaitán, P. Pantazis, T. Bollenbach   +12 more
core   +1 more source

Intestinal macromolecular transport supporting adaptive immunity [PDF]

, 2019
The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
core   +2 more sources

Endocytosis and transcytosis of gliadin peptides [PDF]

Molecular and Cellular Pediatrics, 2016
Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have different biological effects. Gliadin peptides can induce innate and adaptive T cell-mediated immune responses.
Barone, M Vittoria, Zimmer, K Peter
openaire   +3 more sources

Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease. [PDF]

, 2014
UnlabelledCryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in patients with a compromised immune system.
Bautos, Jennifer M, Gelli, Angie, Jamklang, Mantana, Na Pombejra, Sarisa, Tham, Rick, Thompson, George R, Uhrig, John P, Vu, Kiem   +7 more
core   +2 more sources

Receptor-mediated transcytosis for brain delivery of therapeutics: receptor classes and criteria

Frontiers in Drug Delivery
The delivery of therapeutics into the brain is highly limited by the blood-brain barrier (BBB). Although this is essential to protect the brain from potentially harmful material found in the blood, it poses a great challenge for the treatment of diseases
A. Haqqani, K. Bélanger, Danica B. Stanimirovic   +2 more
semanticscholar   +1 more source

The role of transcytosis in the blood-retina barrier: from pathophysiological functions to drug delivery

Frontiers in Pharmacology
The blood-retina barrier (BRB) serves as a critical interface that separates the retina from the circulatory system, playing an essential role in preserving the homeostasis of the microenvironment within the retina.
Chun-Lin Zhang, Jing-Jie Ma, Xiang Li, Hai-Qing Yan, Yong-Kun Gui, Zhi-Xin Yan, Ming-Feng You, Ping Zhang   +7 more
doaj   +1 more source