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Role of Caveolae and Caveolin in Vascular Physiology and Pathology [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseCaveolae, 50–100 nm cholesterol‐rich plasma membrane invaginations, serve as critical signaling hubs in vascular cells. These structures—scaffolded by caveolin proteins (CAV1, CAV2, CAV3) and regulated by Cavins—orchestrate membrane dynamics ...
Chi Zhang +4 more
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Nature Communications, 2022 Caveolae are small coated plasma membrane invaginations with diverse functions. Caveolae undergo curvature changes. Yet, it is unclear which proteins regulate this process. To address this gap, we develop a correlative stimulated emission depletion (STED)
Justin Taraska +2 more
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Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration [PDF]
Nature CommunicationsMigrating cells dynamically adapt their morphogenetic programs in response to microenvironmental changes, requiring coordinated spatiotemporal integration of mechanical and biochemical signals.
Vibha Singh +8 more
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Cavin gene family and caveolae-related disorders: pathogenetic roles and possible mechanisms [PDF]
Cell Communication and SignalingCavins, in concert with caveolins, orchestrate the formation and function of caveolae—specialized invaginations of the plasma membrane involved in mechanotransduction, lipid homeostasis, and cell signaling. The Cavin family comprises four members: Cavins
Youssef Osman +4 more
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Computational and Structural Biotechnology Journal, 2023 Caveolae are nanoscopic and mechanosensitive invaginations of the plasma membrane, essential for adipocyte biology. Transmission electron microscopy (TEM) offers the highest resolution for caveolae visualization, but provides complicated images that are ...
María C.M. Aboy-Pardal +7 more
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Caveolae couple mechanical stress to integrin recycling and activation
eLife, 2022 Cells are subjected to multiple mechanical inputs throughout their lives. Their ability to detect these environmental cues is called mechanosensing, a process in which integrins play an important role. During cellular mechanosensing, plasma membrane (PM)
Fidel-Nicolás Lolo +8 more
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Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix
Cells, 2023 The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt and respond to them. PM invaginations named caveolae, with a specific protein and lipid composition, play a crucial role in this mechanosensing and mechanotransduction
Laura Sotodosos-Alonso +2 more
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Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP
Nature Communications, 2022 The translation of mechanical cues into gene expression changes is dependent on the nuclear import of mechanoresponsive transcriptional regulators. Here the authors identify that Importin-7 drives the nuclear import of one such regulator YAP while YAP ...
María García-García +12 more
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Caveolar fatty acids and acylation of caveolin-1. [PDF]
PLoS ONE, 2013 Caveolae are cholesterol and sphingolipids rich subcellular domains on plasma membrane. Caveolae contain a variety of signaling proteins which provide platforms for signaling transduction.
Qian Cai +3 more
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Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion. [PDF]
PLoS ONE, 2012 Caveolae, little caves of cell surfaces, are enriched in cholesterol, a certain level of which is required for their structural integrity. Here we show in adipocytes that cavin-2, a peripheral membrane protein and one of 3 cavin isoforms present in ...
Michael R Breen +4 more
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