Results 1 to 10 of about 44,676 (226)

Role of Caveolae and Caveolin in Vascular Physiology and Pathology [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Caveolae, 50–100 nm cholesterol‐rich plasma membrane invaginations, serve as critical signaling hubs in vascular cells. These structures—scaffolded by caveolin proteins (CAV1, CAV2, CAV3) and regulated by Cavins—orchestrate membrane dynamics ...
Chi Zhang, Wenting Hu, Jiaye Zhang, Zanxin Wang, Haocheng Lu   +4 more
doaj   +2 more sources

Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration [PDF]

Nature Communications
Migrating cells dynamically adapt their morphogenetic programs in response to microenvironmental changes, requiring coordinated spatiotemporal integration of mechanical and biochemical signals.
Vibha Singh, Victor Breton, Christine Viaris de Lesegno, Anne-Sophie Macé, Philippe Bun, Cédric M. Blouin, Amit Singh Vishen, Pierre Sens, Christophe Lamaze   +8 more
doaj   +2 more sources

Pathophysiological Role of Caveolae in Hypertension [PDF]

Frontiers in Medicine, 2019
Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1–4, EHD2, pacsin2, and dynamin 2.
Xiaoming Lian, Claudia Matthaeus, Mario Kaßmann, Oliver Daumke, Maik Gollasch, Maik Gollasch   +5 more
doaj   +4 more sources

Potential of caveolae in the therapy of cardiovascular and neurological diseases [PDF]

Frontiers in Physiology, 2014
Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated ...
Gemma eNavarro, Kjell eFuxe, Dasiel Oscar Borroto-Escuela, Rafael eFranco   +3 more
doaj   +3 more sources

Cavin gene family and caveolae-related disorders: pathogenetic roles and possible mechanisms [PDF]

Cell Communication and Signaling
Cavins, in concert with caveolins, orchestrate the formation and function of caveolae—specialized invaginations of the plasma membrane involved in mechanotransduction, lipid homeostasis, and cell signaling. The Cavin family comprises four members: Cavins
Youssef Osman, Nuraly S. Akimbekov, Emad M El-Zayat, Nourhan Hassan, Ilya Digel   +4 more
doaj   +2 more sources

Ion Channel Regulation in Caveolae and Its Pathological Implications [PDF]

Cells
Caveolae are distinctive, flask-shaped structures within the cell membrane that play critical roles in cellular signal transduction, ion homeostasis, and mechanosensation.
Jianyi Huo, Liangzhu Mo, Xiaojing Lv, Yun Du, Huaqian Yang   +4 more
doaj   +2 more sources

Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity [PDF]

Journal of Lipid Research, 2011
Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null ...
Tova Meshulam, Michael R. Breen, Libin Liu, Robert G. Parton, Paul F. Pilch   +4 more
doaj   +3 more sources

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]

, 2015
Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
A Adebiyi, A Cheong, A Cogolludo, A Moreno-Dominguez, AJ Wilson, AM Brainard, B Kyle, B Razani, B Razani, C Dart, C Dart, Carl P. Nelson, CL Moore, CP Nelson, CP Nelson, DP McEwen, DW Carr, EA Aiello, EA Aiello, EA Ko, EA Ko, F Plane, GC Wellman, GI Purves, H Li, H Miyoshi, HS Mason, IA Greenwood, J Couet, J Moral-Sanz, JB Stott, JD Scott, JD Turner, Jennifer L. Brignell, JM Quayle, Jonathon M. Willets, JR Martens, KD Luykenaar, KS Park, LF Santana, LJ Sampson, LM Davies, M Colledge, Mark S. Shapiro, Matthew D. Perry, MF Navedo, MG Gold, MT Nelson, NM Alto, NN Orie, Noel W. Davies, O Clement-Chomienne, P Skroblin, R. A. John Challiss, RD Rainbow, RD Rainbow, RD Rainbow, RH Cox, RT Dobrowsky, SA Barman, VM Coghlan, Y Hayabuchi, Y Hayabuchi, Y Hayabuchi, Y Yang   +64 more
core   +13 more sources

A deep learning-based tool for the automated detection and analysis of caveolae in transmission electron microscopy images

Computational and Structural Biotechnology Journal, 2023
Caveolae are nanoscopic and mechanosensitive invaginations of the plasma membrane, essential for adipocyte biology. Transmission electron microscopy (TEM) offers the highest resolution for caveolae visualization, but provides complicated images that are ...
María C.M. Aboy-Pardal, Daniel Jimenez-Carretero, Sara Terrés-Domínguez, Dácil M. Pavón, Laura Sotodosos-Alonso, Víctor Jiménez-Jiménez, Fátima Sánchez-Cabo, Miguel A. Del Pozo   +7 more
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Caveolae couple mechanical stress to integrin recycling and activation

eLife, 2022
Cells are subjected to multiple mechanical inputs throughout their lives. Their ability to detect these environmental cues is called mechanosensing, a process in which integrins play an important role. During cellular mechanosensing, plasma membrane (PM)
Fidel-Nicolás Lolo, Dácil María Pavón, Araceli Grande-García, Alberto Elosegui-Artola, Valeria Inés Segatori, Sara Sánchez, Xavier Trepat, Pere Roca-Cusachs, Miguel A del Pozo   +8 more
doaj   +1 more source