Results 1 to 10 of about 57,111 (301)

Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond [PDF]

Frontiers in Immunology, 2017
Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1 ...
Cecília Jacques Gonçalves de Almeida
exaly   +6 more sources

Caveolin-1 Dependent Endocytosis Enhances the Chemosensitivity of HER-2 Positive Breast Cancer Cells to Trastuzumab Emtansine (T-DM1).

PLoS ONE, 2015
The humanized monoclonal antibody-drug conjugate trastuzumab emtansine (T-DM1, Kadcyla) has been approved by the U.S. FDA to treat human epidermal growth factor receptor 2 (HER-2)-positive metastatic breast cancer.
Yuan-Chiang Chung, Jang-Fang Kuo, Wan-Chen Wei, King-Jen Chang, Wei-Ting Chao   +4 more
doaj   +2 more sources

Upregulation of aquaporin-2 and caveolins in rat bladder with outlet obstruction-induced detrusor overactivity [PDF]

Investigative and Clinical Urology
Purpose: Bladder outlet obstruction (BOO) leads to detrusor overactivity (DO) and structural remodeling of the bladder. However, the molecular mechanisms underlying this process remain incompletely understood.
Seong Hyeon Yu, Ho Seok Chung, Do Gyeong Lim, Sun-Ouck Kim   +3 more
doaj   +2 more sources

Regulation of caveolin and caveolae by cholesterol in MDCK cells

Journal of Lipid Research, 1998
We have examined the expression of caveolin in MDCK cells under conditions that vary cellular cholesterol concentration. Caveolin mRNA levels dropped to one-sixth of control levels after treatment with simvastatin, an inhibitor of cholesterol synthesis ...
Robert Parton
exaly   +3 more sources

Decreased Expression of Urethral Caveolin-1, −2, and −3 in the Rat Model of Overactive Bladder: Potential Mediator of Functional Interaction of Urethra and Urinary Bladder [PDF]

International Neurourology Journal, 2023
Purpose To investigate the effect of detrusor overactivity (DO) on the urethral expression of caveolin (CAV)-1, −2, and −3 of urethra in an animal model of cyclophosphamide (CYP)-induced cystitis rat.
Hyun Jin Cho, Han-Yi Jiao, Sun-Ouck Kim
doaj   +1 more source

P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis

Nature Materials, 2023
Targeting of tumour vasculature endothelial P-selectin promotes caveolin-1-mediated transcytosis for enhanced blood–brain barrier crossing of therapeutic nanoparticles against medulloblastoma. Medulloblastoma is the most common malignant paediatric brain
Daniel E Tylawsky, Hiroto Kiguchi, Jake Vaynshteyn, Jeffrey Gerwin, Janki Shah, Taseen Islam, Jacob A Boyer, D. Boue, M. Snuderl, M. Greenblatt, Yosi Shamay, G. P. Raju, Daniel A. Heller   +12 more
semanticscholar   +1 more source

Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival

Frontiers in Cellular Neuroscience, 2023
Introduction: Caveolin-1 and Caveolin-2 (CAV1 and CAV2) are proteins associated with intercellular neurotrophic signalling. There is converging evidence that CAV1 and CAV2 (CAV1/2) genes have a role in amyotrophic lateral sclerosis (ALS).
Brett N. Adey, Brett N. Adey, Johnathan Cooper-Knock, Ahmad Al Khleifat, Isabella Fogh, Philip van Damme, Philip van Damme, Philip van Damme, Philippe Corcia, Philippe Corcia, Philippe Couratier, Philippe Couratier, Orla Hardiman, Russell McLaughlin, Marc Gotkine, Marc Gotkine, Vivian Drory, Vivian Drory, Vincenzo Silani, Vincenzo Silani, Nicola Ticozzi, Nicola Ticozzi, Jan H. Veldink, Leonard H. van den Berg, Mamede de Carvalho, Susana Pinto, Jesus S. Mora Pardina, Mónica Povedano Panades, Peter M. Andersen, Markus Weber, Nazli A. Başak, Christopher E. Shaw, Pamela J. Shaw, Karen E. Morrison, John E. Landers, Jonathan D. Glass, Patrick Vourc’h, Patrick Vourc’h, Richard J. B. Dobson, Richard J. B. Dobson, Richard J. B. Dobson, Richard J. B. Dobson, Gerome Breen, Ammar Al-Chalabi, Ammar Al-Chalabi, Ashley R. Jones, Alfredo Iacoangeli, Alfredo Iacoangeli, Alfredo Iacoangeli   +48 more
doaj   +1 more source

Molecular architecture of the human caveolin-1 complex

bioRxiv, 2022
Membrane sculpting proteins shape the morphology of cell membranes and facilitate remodeling in response to physiological and environmental cues. Complexes of the monotopic membrane protein caveolin function as essential curvature-generating components ...
J. Porta, Bing Han, Alican Gulsevin, Jeong Min Chung, Y. Peskova, S. Connolly, H. Mchaourab, J. Meiler, E. Karakas, A. Kenworthy, M. Ohi   +10 more
semanticscholar   +1 more source

Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation.

Metabolism: Clinical and Experimental, 2022
BACKGROUND Atherosclerosis (AS) is the basis of diabetic macrovascular complications. The plasma low-density lipoprotein (LDL) particles transcytosis across endothelial cells (ECs) and deposition under the endothelium is the initiation step of AS.
Ying Zhao, Xiong Jia, Xiao-Yan Yang, X. Bai, Ya-Jing Lu, Lin Zhu, Wenzhuo Cheng, Meng Shu, Yan Zhu, Xia-Jin Du, Li Wang, Y. Shu, Yi Song, Si Jin   +13 more
semanticscholar   +1 more source

#123 : Caveolin-1 Function and Regulation in Mouse Uterus During Early Pregnancy and Under Human In Vitro Decidualization

Fertility & Reproduction, 2023
Background and Aims: Endometrial decidualization is a step in establishing and maintaining pregnancy. Senescence was considered to accompany with decidualization.
Song Zhuo
doaj   +1 more source