Results 21 to 30 of about 57,111 (301)

The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems

Acta Pharmaceutica Sinica B, 2020
As one of the most important components of caveolae, caveolin-1 is involved in caveolae-mediated endocytosis and transcytosis pathways, and also plays a role in regulating the cell membrane cholesterol homeostasis and mediating signal transduction.
Can-Yu Yang, Bing He, Wen-Bing Dai, Hua Zhang, Ying Zheng, Xueqing Wang, Qiang Zhang   +6 more
semanticscholar   +1 more source

A Role for Caveolin-3 in the Pathogenesis of Muscular Dystrophies

International Journal of Molecular Sciences, 2020
Caveolae are the cholesterol-rich small invaginations of the plasma membrane present in many cell types including adipocytes, endothelial cells, epithelial cells, fibroblasts, smooth muscles, skeletal muscles and cardiac muscles.
B. S. Pradhan, T. Prószyński
semanticscholar   +1 more source

Simultaneous induction of an HDL receptor protein (SR-BI) and the selective uptake of HDL-cholesteryl esters in a physiologically relevant steroidogenic cell model

Journal of Lipid Research, 1998
This study addresses the question of whether the level of expression of SR-BI (an HDL receptor) is linked to the expression of selective lipoprotein-cholesteryl ester delivery in a steroidogenic cell model. Rat ovarian granulosa cells are physiologically
Salman Azhar, Ann Nomoto, Susan Leers-Sucheta, Eve Reaven   +3 more
doaj   +1 more source

Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. [PDF]

PLoS ONE, 2014
Caveolin-1 is a scaffolding/regulatory protein that interacts with diverse signaling molecules. Caveolin-1(null) mice have marked metabolic abnormalities, yet the underlying molecular mechanisms are incompletely understood.
Takashi Shiroto, Natalia Romero, Toru Sugiyama, Juliano L Sartoretto, Hermann Kalwa, Zhonghua Yan, Hiroaki Shimokawa, Thomas Michel   +7 more
doaj   +1 more source

Caveolin-1 protects B6129 mice against Helicobacter pylori gastritis. [PDF]

, 2013
Caveolin-1 (Cav1) is a scaffold protein and pathogen receptor in the mucosa of the gastrointestinal tract. Chronic infection of gastric epithelial cells by Helicobacter pylori (H. pylori) is a major risk factor for human gastric cancer (GC) where Cav1 is
Ivana Hitkova (401838), Ivana Hitkova, Matthias P. A. Ebert, Florian Anderl (183670), Thomas Kirchner (109827), Matthias P A Ebert, Roland M Schmid, Schmid, Roland M., Thomas Kirchner, Claus Schäfer, Roger Vogelmann (358771), Markus Gerhard (183676), Florian Anderl, Elke Burgermeister, Yuan, Gang, Simone Reu, Christoph Röcken (170345), Roland M. Schmid (130086), Ebert, Matthias P. A., Christoph Röcken, Reu, Simone, Schäfer, Claus, Gang Yuan, Vogelmann, Roger, Claus Schäfer (401841), Hitkova, Ivana, Anderl, Florian, Markus Gerhard, Roger Vogelmann, Simone Reu (401840), Röcken, Christoph, Gang Yuan (401839), Matthias P. A. Ebert (250492), Roland M. Schmid, Elke Burgermeister (401842), Kirchner, Thomas, Burgermeister, Elke, Gerhard, Markus   +37 more
core   +2 more sources

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models [PDF]

, 2014
Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor,
Bieneck, S, Muñoz, N, Quest, AF, Bennett, DC, Silva, V, Sviderskayae, Elena V., Lobos González, Lorena, Muñoz, Nicolás, Fernandez, JG, Silva, Verónica, Hossain, Mehnaz, Bennett, Dorothy C., Fernández Ruiz, Jaime Gonzalo, Quest, Andrew F. G., Burzio, V, Leyton, L, Quest, Andrew F.G., Lobos-Gonzalez, L, Bieneck, Simone, Sviderskaya, EV, Burzioc, Verónica, Aguilar Guzmán, Lorena, Hossain, M, Aguilar Guzmán, Lorena Andrea, Aguilar-Guzmán, L, Leyton Campos, Lisette   +25 more
core   +1 more source

A simplified method for the preparation of detergent-free lipid rafts

Journal of Lipid Research, 2005
Lipid rafts are small plasma membrane domains that contain high levels of cholesterol and sphingolipids. Traditional methods for the biochemical isolation of lipid rafts involve the extraction of cells with nonionic detergents followed by the separation ...
Jennifer L. Macdonald, Linda J. Pike
doaj   +1 more source

Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis. [PDF]

PLoS ONE, 2012
Caveolin-1, the structural protein component of caveolae, acts as a scaffolding protein that functionally regulates signaling molecules. We show that knockdown of caveolin-1 protein expression enhances chemotherapeutic drug-induced apoptosis and inhibits
Huafei Zou, Daniela Volonte, Ferruccio Galbiati   +2 more
doaj   +1 more source

Caveolin Revealed: A Mutagenesis Study of Caveolin-1 [PDF]

Biophysical Journal, 2015
Caveolae are 50-100 nm invaginations in the plasma membrane that are rich in cholesterol, sphingomyelin and the integral membrane protein called caveolin-1. Caveolin-1 has three main functions: forming caveolae, cell signaling, and endocytosis. To examine the importance of conserved residues within the scaffolding and intra-membrane domains of caveolin-
Plucinsky, Sarah, Glover, Kerney J.
openaire   +1 more source

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress .pdf

, 2023
Caveolin-1 precludes stress-induced protein kinase A-dependent remodelling of endoplasmic reticulum–mitochondria communication.
Beverly Rothermel (16463091)
core   +1 more source