Cavin‐1/PTRF alters prostate cancer cell‐derived extracellular vesicle content and internalization to attenuate extracellular vesicle‐mediated osteoclastogenesis and osteoblast proliferation [PDF]
Journal of Extracellular Vesicles, 2014 Background: Tumour-derived extracellular vesicles (EVs) play a role in tumour progression; however, the spectrum of molecular mechanisms regulating EV secretion and cargo selection remain to be fully elucidated.
Kerry L Inder +2 more
exaly +6 more sources
Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis [PDF]
Nature Communications, 2019 Caveolae are plasma membrane invaginations containing cavin proteins that are disrupted upon stress stimuli, causing cavin release inside the cell. Here, McMahon et al.
Kerrie-Ann McMahon +2 more
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Cavin‐2 promotes fibroblast‐to‐myofibroblast trans‐differentiation and aggravates cardiac fibrosis [PDF]
ESC Heart FailureAims Transforming growth factor β (TGF‐β) signalling is one of the critical pathways in fibroblast activation, and several drugs targeting the TGF‐β/Smad signalling pathway in heart failure with cardiac fibrosis are being tested in clinical trials.
Takehiro Ogata, Naohiko Nakanishi
exaly +3 more sources
CAVIN-2 positively correlates with diabetic PAD and promotes LDL transcytosis by inhibiting eNOS activation [PDF]
Annals of MedicineObjective Caveolae are closely linked to the onset and progression of atherosclerosis. The pivotal involvement of caveolin-1 (CAV1) within the caveolae in atherosclerosis development has been consistently supported.
Li Wang +10 more
doaj +2 more sources
Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation
Molecular Metabolism, 2022 Objective: Adipogenesis plays an essential role in maintaining energy and hormonal balance. Cavin-2, one of the caveolae-related proteins, is abundant in adipocytes, the leading site of adipogenesis.
Takehiro Ogata +2 more
exaly +3 more sources
Heliyon, 2023 Pulmonary hypertension (PH) is associated with a poor prognosis even in recent years. Caveolin-1 (CAV1), a caveolae-associated protein, is a causal gene in PH.
Takehiro Ogata +2 more
exaly +3 more sources
Role of Caveolae family-related proteins in the development of breast cancer [PDF]
Frontiers in Molecular Biosciences, 2023 Breast cancer has become the most significant malignant tumor threatening women’s lives. Caveolae are concave pits formed by invagination of the plasma membrane that participate in many biological functions of the cell membrane, such as endocytosis, cell
Qinyu Han +4 more
doaj +2 more sources
Exosome-Based Cartilage-Targeted Delivery System: Strategies and Applications. [PDF]
Small SciConstruction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Wang Y, Chen B, Zhu H, Sun Z.
europepmc +2 more sources
Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer [PDF]
BMC CancerCaveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable
Kelin Mou +12 more
doaj +2 more sources
High‐Throughput Immunoassays for Cavin‐4 IgG: A Diagnostic Tool for Immune‐Mediated Rippling Muscle Disease [PDF]
Annals of Clinical and Translational NeurologyCavin‐4 was identified as a potential autoantigen for immune‐mediated rippling muscle disease (iRMD). To validate this, we developed and tested various immunoassays, including a cell‐based assay (CBA), cavin‐4 recombinant protein ELISA, and multi‐peptide
Reghann G. LaFrance‐Corey +13 more
doaj +2 more sources