Results 11 to 20 of about 5,482 (203)

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis [PDF]

Nature Communications, 2019
Caveolae are plasma membrane invaginations containing cavin proteins that are disrupted upon stress stimuli, causing cavin release inside the cell. Here, McMahon et al.
Kerrie-Ann McMahon, Yeping Wu, Yann Gambin, Emma Sierecki, Vikas A. Tillu, Thomas Hall, Nick Martel, Satomi Okano, Shayli Varasteh Moradi, Jayde E. Ruelcke, Charles Ferguson, Alpha S. Yap, Kirill Alexandrov, Michelle M. Hill, Robert G. Parton   +14 more
doaj   +7 more sources

Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance.

PLoS ONE, 2014
The cavins are a family of proteins associated with caveolae, cavin-1, -2 and -3 being widely expressed while cavin-4 is restricted to striated muscle.
Libin Liu, Carsten G Hansen, Brian J Honeyman, Benjamin J Nichols, Paul F Pilch   +4 more
doaj   +5 more sources

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability [PDF]

Nature Communications, 2018
SOCS3 is an important negative feedback inhibitor of JAK–STAT-mediated cytokine signalling. Here the authors implicate cavin-1 — an essential component of caveolae — in the recruitment of SOCS3 to the plasma membrane to prevent sustained cytokine ...
Jamie J. L. Williams, Nasser Alotaiq, William Mullen, Richard Burchmore, Libin Liu, George S. Baillie, Fred Schaper, Paul F. Pilch, Timothy M. Palmer   +8 more
doaj   +8 more sources

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes [PDF]

Journal of Cell Biology, 2009
Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds ...
Bastiani, Michele, Hill, Michelle M., Nixon, Susan J., Lo, Harriet P., Abankwa, Daniel, Luetterforst, Robert, Fernandez-Rojo, Manuel, Breen, Michael R., Vinten, Jorgen, Walser, Piers J., North, Kathryn N., Hancock, John F., Pilch, Paul F., Parton, Robert G., Liu, Libin, Jedrychowski, Mark, Gygi, Steven   +16 more
openaire   +8 more sources

Case Report: Anti-cavin-4-positive immune-mediated rippling muscle disease co-occurring with isolated ocular myasthenia gravis [PDF]

Frontiers in Immunology
Immune-mediated rippling muscle disease (iRMD) is a rare autoimmune myopathy characterized by mechanically triggered, wave-like skeletal muscle contractions. Its coexistence with myasthenia gravis (MG) has been described, but detailed clinicopathological
Baitong Wang, Anzhe Zheng, Mingshi Gao, Dongyue Yue, Wenhua Zhu, Zhiguo Lv, Jianying Xi   +6 more
doaj   +2 more sources

Prognostic and Diagnostic Significance of SDPR-Cavin-2 in Hepatocellular Carcinoma

Cellular Physiology and Biochemistry, 2016
Background: Hepatocellular carcinoma (HCC) is a malignant tumor worldwide. Due to the lack of early prediction marker, numerous patients were diagnosed in their late stage.
Wei Jing, Ping Luo, Man Zhu, Qian Ai, Hongyan Chai, Jiancheng Tu   +5 more
doaj   +2 more sources

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells [PDF]

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +2 more sources

Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer [PDF]

BMC Cancer
Caveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable
Kelin Mou, Huan Wang, Siqi Zhu, Jing Luo, Jianmei Wang, Lin Peng, Yulin Lei, Yunke Zhang, Shike Huang, Huarong Zhao, Gang Li, Li Xiang, Yuhao Luo   +12 more
doaj   +2 more sources

High‐Throughput Immunoassays for Cavin‐4 IgG: A Diagnostic Tool for Immune‐Mediated Rippling Muscle Disease [PDF]

Annals of Clinical and Translational Neurology
Cavin‐4 was identified as a potential autoantigen for immune‐mediated rippling muscle disease (iRMD). To validate this, we developed and tested various immunoassays, including a cell‐based assay (CBA), cavin‐4 recombinant protein ELISA, and multi‐peptide
Reghann G. LaFrance‐Corey, Haidara Kherbek, Nimalan Harinesan, Margherita Milone, Naveen K. Paramasivan, Pallab Sarker, Andrew M. Knight, Carley Karsten, Surendra Dasari, Teerin Liewluck, William J. Litchy, Sean J. Pittock, John R. Mills, Divyanshu Dubey   +13 more
doaj   +2 more sources

TRIM59 Drives Bladder Cancer Progression Through E3 Ligase‐Dependent K48‐Linked Degradation of PTRF [PDF]

Cancer Science, EarlyView.
Schematic model of TRIM59‐driven BLCA progression through K48‐linked ubiquitination and proteasomal degradation of PTRF, leading to AKT activation and c‐Myc upregulation. ABSTRACT Tripartite motif‐containing 59 (TRIM59) is an E3 ubiquitin ligase implicated in multiple malignancies, but its role in bladder cancer (BLCA) remains incompletely understood ...
Junlin Gan, Xuesong Bai, Aijie Zhang, Fei Lin, Hang Tong, Tinghao Li, Ning Xu, Xinyuan Li, Zhou Yu, Hubin Yin   +9 more
wiley   +2 more sources