CAVIN-2 positively correlates with diabetic PAD and promotes LDL transcytosis by inhibiting eNOS activation [PDF]
Annals of MedicineObjective Caveolae are closely linked to the onset and progression of atherosclerosis. The pivotal involvement of caveolin-1 (CAV1) within the caveolae in atherosclerosis development has been consistently supported.
Li Wang +10 more
exaly +7 more sources
Cavin-2 Promotes Fibroblast-to-Myofibroblast Trans-Differentiation and Aggravates Cardiac Fibrosis [PDF]
ESC Heart Failure, 2023 Aims Transforming growth factor β (TGF‐β) signalling is one of the critical pathways in fibroblast activation, and several drugs targeting the TGF‐β/Smad signalling pathway in heart failure with cardiac fibrosis are being tested in clinical trials.
Takehiro Ogata
exaly +4 more sources
Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis [PDF]
Nature Communications, 2019 Caveolae are plasma membrane invaginations containing cavin proteins that are disrupted upon stress stimuli, causing cavin release inside the cell. Here, McMahon et al.
Kerrie-Ann McMahon +14 more
doaj +9 more sources
Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability [PDF]
Nature Communications, 2018 SOCS3 is an important negative feedback inhibitor of JAK–STAT-mediated cytokine signalling. Here the authors implicate cavin-1 — an essential component of caveolae — in the recruitment of SOCS3 to the plasma membrane to prevent sustained cytokine ...
Jamie J. L. Williams +8 more
doaj +9 more sources
Heliyon, 2023 Pulmonary hypertension (PH) is associated with a poor prognosis even in recent years. Caveolin-1 (CAV1), a caveolae-associated protein, is a causal gene in PH.
Takehiro Ogata +2 more
exaly +4 more sources
Prognostic and Diagnostic Significance of SDPR-Cavin-2 in Hepatocellular Carcinoma [PDF]
Cellular Physiology and Biochemistry, 2016 Background: Hepatocellular carcinoma (HCC) is a malignant tumor worldwide. Due to the lack of early prediction marker, numerous patients were diagnosed in their late stage.
Wei Jing +5 more
doaj +6 more sources
Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation
Molecular Metabolism, 2022 Objective: Adipogenesis plays an essential role in maintaining energy and hormonal balance. Cavin-2, one of the caveolae-related proteins, is abundant in adipocytes, the leading site of adipogenesis.
Takehiro Ogata +2 more
exaly +4 more sources
High‐Throughput Immunoassays for Cavin‐4 IgG: A Diagnostic Tool for Immune‐Mediated Rippling Muscle Disease [PDF]
Annals of Clinical and Translational NeurologyCavin‐4 was identified as a potential autoantigen for immune‐mediated rippling muscle disease (iRMD). To validate this, we developed and tested various immunoassays, including a cell‐based assay (CBA), cavin‐4 recombinant protein ELISA, and multi‐peptide
Reghann G. LaFrance‐Corey +13 more
doaj +3 more sources
The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding [PDF]
Communications BiologyCaveolin-1 (CAV1) and Cavin-1 are components of caveolae, both of which interact with and influence the composition and stabilization of caveolae. CAV1 is associated with pulmonary arterial hypertension (PAH).
Shinya Tomita +7 more
doaj +3 more sources
Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. [PDF]
PLoS ONE, 2014 The cavins are a family of proteins associated with caveolae, cavin-1, -2 and -3 being widely expressed while cavin-4 is restricted to striated muscle.
Libin Liu +4 more
doaj +5 more sources