Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability [PDF]
Nature Communications, 2018 SOCS3 is an important negative feedback inhibitor of JAK–STAT-mediated cytokine signalling. Here the authors implicate cavin-1 — an essential component of caveolae — in the recruitment of SOCS3 to the plasma membrane to prevent sustained cytokine ...
Jamie J L Williams +2 more
exaly +7 more sources
Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity [PDF]
Journal of Lipid Research, 2011 Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null ...
Tova Meshulam +4 more
doaj +3 more sources
Cavin-3 dictates the balance between ERK and Akt signaling
eLife, 2013 Cavin-3 is a tumor suppressor protein of unknown function. Using both in vivo and in vitro approaches, we show that cavin-3 dictates the balance between ERK and Akt signaling.
Victor J Hernandez +8 more
doaj +3 more sources
Unraveling calcium dysregulation and autoimmunity in immune mediated rippling muscle disease [PDF]
Acta Neuropathologica CommunicationsRippling Muscle Disease (RMD) is a rare skeletal myopathy characterized by abnormal muscular excitability manifesting with wave-like muscle contractions and percussion-induced muscle mounding.
Samir R. Nath +10 more
doaj +2 more sources
Immune Priming and the Risk of COVID-19, Influenza, and Other Acute Respiratory Infections: Insights From an N3C Cohort. [PDF]
Influenza Other Respir VirusesABSTRACT Background The emergence of SARS‐CoV‐2 and introduction of COVID‐19 vaccines into immunologically naïve populations may alter the dynamics of other acute viral respiratory infections (viral ARIs) and vice versa. Competing forces, including viral interference, cross‐reactive immunity, shared susceptibility, and immune dysregulation, may affect ...
León TM +4 more
europepmc +2 more sources
The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding [PDF]
Communications BiologyCaveolin-1 (CAV1) and Cavin-1 are components of caveolae, both of which interact with and influence the composition and stabilization of caveolae. CAV1 is associated with pulmonary arterial hypertension (PAH).
Shinya Tomita +7 more
doaj +2 more sources
PLoS ONE, 2014 The cavins are a family of proteins associated with caveolae, cavin-1, -2 and -3 being widely expressed while cavin-4 is restricted to striated muscle.
Libin Liu +4 more
doaj +4 more sources
Cavin gene family and caveolae-related disorders: pathogenetic roles and possible mechanisms [PDF]
Cell Communication and SignalingCavins, in concert with caveolins, orchestrate the formation and function of caveolae—specialized invaginations of the plasma membrane involved in mechanotransduction, lipid homeostasis, and cell signaling. The Cavin family comprises four members: Cavins
Youssef Osman +4 more
doaj +2 more sources
Endocytic crosstalk: cavins, caveolins, and caveolae regulate clathrin-independent endocytosis.
PLoS Biology, 2014 Several studies have suggested crosstalk between different clathrin-independent endocytic pathways. However, the molecular mechanisms and functional relevance of these interactions are unclear.
Natasha Chaudhary +10 more
doaj +5 more sources
Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane [PDF]
eLifeLarge transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier.
Camille Morel +17 more
doaj +2 more sources