Results 31 to 40 of about 7,336 (225)

Acetylation of Cavin-1 Promotes Lipolysis in White Adipose Tissue [PDF]

Molecular and Cellular Biology, 2017
White adipose tissue (WAT) serves as a reversible energy storage depot in the form of lipids in response to nutritional status. Cavin-1, an essential component in the biogenesis of caveolae, is a positive regulator of lipolysis in adipocytes. However, molecular mechanisms of cavin-1 in the modulation of lipolysis remain poorly understood.
Liang Guo, Xu Wang, Yuan Liu
exaly   +4 more sources

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies. [PDF]

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Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Frisby D, Misri G, Naslavsky N, Caplan S.   +3 more
europepmc   +2 more sources

IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. [PDF]

PLoS ONE, 2010
BACKGROUND:Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling.
Barbara Salani, Mario Passalacqua, Sara Maffioli, Lucia Briatore, Meriem Hamoudane, Paola Contini, Renzo Cordera, Davide Maggi   +7 more
doaj   +3 more sources

Cavin-1/PTRF mediates insulin-dependent focal adhesion remodeling and ameliorates high-fat diet–induced inflammatory responses in mice

Journal of Biological Chemistry, 2019
Cavin-1/polymerase I and transcript release factor (PTRF) is a requisite component of caveolae, small plasma membrane invaginations that are highly abundant in adipocytes.
Libin Liu, Paul Pilch
exaly   +2 more sources

Adversarial Erasing Enhanced Multiple Instance Learning (siMILe): Discriminative Identification of Oligomeric Protein Structures in Single Molecule Localization Microscopy

Advanced Intelligent Systems
Single‐molecule localization microscopy (SMLM) achieves nanoscale imaging of complex protein structures in the cell. However, the ability to capture structural variability across cell conditions (cell lines, gene expression, treatment) from 3D point ...
Christian Hallgrimson, Y. Lydia Li, Claire A. Shou, Ben Cardoen, John Lim, Timothy H. Wong, Ismail M. Khater, Ivan Robert Nabi, Ghassan Hamarneh   +8 more
doaj   +2 more sources

Unraveling calcium dysregulation and autoimmunity in immune mediated rippling muscle disease [PDF]

Acta Neuropathologica Communications
Rippling Muscle Disease (RMD) is a rare skeletal myopathy characterized by abnormal muscular excitability manifesting with wave-like muscle contractions and percussion-induced muscle mounding.
Samir R. Nath, Aneesha Dasgupta, Divyanshu Dubey, Eileen Kokesh, Grayson Beecher, Numrah Fadra, Teerin Liewluck, Sean Pittock, Jason D. Doles, William Litchy, Margherita Milone   +10 more
doaj   +2 more sources

Muscular dystrophy in PTFR/cavin-1 null mice. [PDF]

JCI Insight, 2017
ice and humans lacking the caveolae component polymerase I transcription release factor (PTRF, also known as cavin-1) exhibit lipo- and muscular dystrophy. Here we describe the molecular features underlying the muscle phenotype for PTRF/cavin-1 null mice.
S. Ding, Libin Liu, P. Pilch
semanticscholar   +3 more sources

Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion. [PDF]

PLoS ONE, 2012
Caveolae, little caves of cell surfaces, are enriched in cholesterol, a certain level of which is required for their structural integrity. Here we show in adipocytes that cavin-2, a peripheral membrane protein and one of 3 cavin isoforms present in ...
Michael R Breen, Marta Camps, Francisco Carvalho-Simoes, Antonio Zorzano, Paul F Pilch   +4 more
doaj   +1 more source

PTRF/Cavin-1 as a Novel RNA-Binding Protein Expedites the NF-κB/PD-L1 Axis by Stabilizing lncRNA NEAT1, Contributing to Tumorigenesis and Immune Evasion in Glioblastoma

Frontiers in Immunology, 2022
Background Immunotherapy, especially checkpoint inhibitors targeting PD-1 or PD-L1, has revolutionized cancer therapy. However, PD-1/PD-L1 inhibitors have not been investigated thoroughly in glioblastoma (GBM).
Kaikai Yi, Xiaoteng Cui, Xing Liu, Yunfei Wang, Jixing Zhao, Shixue Yang, Can Xu, Eryan Yang, Menglin Xiao, Biao Hong, Chuan Fang, Chun-sheng Kang, Yanli Tan, Qixue Wang   +13 more
semanticscholar   +1 more source

PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma

Theranostics, 2022
Background: The concentration and duration of intracellular drugs have always been the key factors for determining the efficacy of the treatment. Efflux of chemotherapeutic drugs or anticancer agents is a major reason for multidrug resistance generation ...
Eryan Yang, Lin Wang, Weili Jin, Xing Liu, Qixue Wang, Ye Wu, Yanli Tan, Yunfei Wang, Xiaoteng Cui, Jixing Zhao, Fei Tong, Biao Hong, Menglin Xiao, Xiaomin Liu, Chuan Fang, Chunsheng Kang   +15 more
semanticscholar   +1 more source