Results 31 to 40 of about 5,482 (203)

Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation

Journal of Extracellular Vesicles, 2014
Background: Tumour-derived extracellular vesicles (EVs) play a role in tumour progression; however, the spectrum of molecular mechanisms regulating EV secretion and cargo selection remain to be fully elucidated.
Kerry L. Inder, Jayde E. Ruelcke, Lara Petelin, Hyeongsun Moon, Eunju Choi, James Rae, Antje Blumenthal, Dietmar Hutmacher, Nicholas A. Saunders, Jennifer L. Stow, Robert G. Parton, Michelle M. Hill   +11 more
doaj   +1 more source

Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. [PDF]

PLoS Genetics, 2010
We investigated eight families with a novel subtype of congenital generalized lipodystrophy (CGL4) of whom five members had died from sudden cardiac death during their teenage years. ECG studies revealed features of long-QT syndrome, bradycardia, as well
Anna Rajab, Volker Straub, Liza J McCann, Dominik Seelow, Raymonda Varon, Rita Barresi, Anne Schulze, Barbara Lucke, Susanne Lützkendorf, Mohsen Karbasiyan, Sebastian Bachmann, Simone Spuler, Markus Schuelke   +12 more
doaj   +1 more source

Revealing Cavin-2 Gene Function in Lung Based on Multi-Omics Data Analysis Method

Frontiers in Cell and Developmental Biology, 2022
Research points out that it is particularly important to comprehensively evaluate immune microenvironmental indicators and gene mutation characteristics to select the best treatment plan.
Changsheng Li, Jingyu Huang, Hexiao Tang, Bing Liu, Bing Liu, Xuefeng Zhou   +5 more
doaj   +1 more source

Downregulation of Cavin‐1 Expression via Increasing Caveolin‐1 Degradation Prompts the Proliferation and Migration of Vascular Smooth Muscle Cells in Balloon Injury–Induced Neointimal Hyperplasia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPercutaneous coronary intervention has been widely used in the treatment of ischemic heart disease, but vascular restenosis is a main limitation of percutaneous coronary intervention.
Li‐Jun Zhou, Xue‐Ying Chen, Shui‐Ping Liu, Lin‐Lin Zhang, Ya‐Nan Xu, Pan‐Wei Mu, Deng‐Feng Geng, Zhi Tan   +7 more
doaj   +1 more source

PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis. [PDF]

PLoS ONE, 2016
Mutations in the PTRF/Cavin-1 gene cause congenital generalized lipodystrophy type 4 (CGL4) associated with myopathy. Additionally, long-QT syndrome and fatal cardiac arrhythmia are observed in patients with CGL4 who have homozygous PTRF/Cavin-1 ...
Takuya Taniguchi, Naoki Maruyama, Takehiro Ogata, Takeru Kasahara, Naohiko Nakanishi, Kotaro Miyagawa, Daisuke Naito, Tetsuro Hamaoka, Masahiro Nishi, Satoaki Matoba, Tomomi Ueyama   +10 more
doaj   +1 more source

Cavin family proteins and the assembly of caveolae

Journal of Cell Science, 2015
ABSTRACT Caveolae are an abundant feature of the plasma membrane in many cells. Until recently, they were generally considered to be membrane invaginations whose formation primarily driven by integral membrane proteins called caveolins. However, the past decade has seen the emergence of the cavin family of peripheral membrane proteins as
Kovtun, Oleksiy, Tillu, Vikas A., Ariotti, Nicholas, Parton, Robert G., Collins, Brett M.   +4 more
openaire   +6 more sources

Muscular dystrophy in PTFR/cavin-1 null mice [PDF]

JCI Insight, 2017
Mice and humans lacking the caveolae component polymerase I transcription release factor (PTRF, also known as cavin-1) exhibit lipo- and muscular dystrophy. Here we describe the molecular features underlying the muscle phenotype for PTRF/cavin-1 null mice.
Shi-Ying Ding, Libin Liu, Paul F. Pilch
openaire   +2 more sources

Pleiotropic Effects of Cavin-1 Deficiency on Lipid Metabolism [PDF]

Journal of Biological Chemistry, 2014
Mice and humans lacking caveolae due to gene knock-out or inactivating mutations of cavin-1/PTRF have numerous pathologies including markedly aberrant fuel metabolism, lipodystrophy, and muscular dystrophy. We characterized the physiologic/metabolic profile of cavin-1 knock-out mice and determined that they were lean because of reduced white adipose ...
Shi-Ying, Ding, Mi-Jeong, Lee, Ross, Summer, Libin, Liu, Susan K, Fried, Paul F, Pilch   +5 more
openaire   +2 more sources

Intermittent Hypoxia Mediates Caveolae Disassembly That Parallels Insulin Resistance Development

Frontiers in Physiology, 2020
Repetitive complete or incomplete pharyngeal collapses are leading to chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA) syndrome responsible for many metabolic disorders.
Maider Varela-Guruceaga, Elise Belaidi, Lucie Lebeau, Ella Aka, Ramaroson Andriantsitohaina, Sophie Giorgetti-Peraldi, Claire Arnaud, Soazig Le Lay   +7 more
doaj   +1 more source

Introduction of caveolae structural proteins into the protozoan Toxoplasma results in the formation of heterologous caveolae but not caveolar endocytosis. [PDF]

PLoS ONE, 2012
Present on the plasma membrane of most metazoans, caveolae are specialized microdomains implicated in several endocytic and trafficking mechanisms. Caveolins and the more recently discovered cavins are the major protein components of caveolae.
Bao Lige, Julia D Romano, Vera Sampels, Sabrina Sonda, Keith A Joiner, Isabelle Coppens   +5 more
doaj   +1 more source