Cavin-2 loss exacerbates hypoxia-induced pulmonary hypertension with excessive eNOS phosphorylation and protein nitration [PDF]
Heliyon, 2023 Pulmonary hypertension (PH) is associated with a poor prognosis even in recent years. Caveolin-1 (CAV1), a caveolae-associated protein, is a causal gene in PH.
Takehiro Ogata +2 more
exaly +9 more sources
Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation [PDF]
Molecular Metabolism, 2022 Objective: Adipogenesis plays an essential role in maintaining energy and hormonal balance. Cavin-2, one of the caveolae-related proteins, is abundant in adipocytes, the leading site of adipogenesis.
Takehiro Ogata +2 more
exaly +9 more sources
Cavin‐2 promotes fibroblast‐to‐myofibroblast trans‐differentiation and aggravates cardiac fibrosis [PDF]
ESC Heart Failure, 2023 Aims Transforming growth factor β (TGF‐β) signalling is one of the critical pathways in fibroblast activation, and several drugs targeting the TGF‐β/Smad signalling pathway in heart failure with cardiac fibrosis are being tested in clinical trials.
Takehiro Ogata, Naohiko Nakanishi
exaly +5 more sources
Revealing Cavin-2 Gene Function in Lung Based on Multi-Omics Data Analysis Method [PDF]
Frontiers in Cell and Developmental Biology, 2022 Research points out that it is particularly important to comprehensively evaluate immune microenvironmental indicators and gene mutation characteristics to select the best treatment plan.
Changsheng Li +5 more
doaj +5 more sources
CAVIN-2 positively correlates with diabetic PAD and promotes LDL transcytosis by inhibiting eNOS activation [PDF]
Annals of MedicineObjective Caveolae are closely linked to the onset and progression of atherosclerosis. The pivotal involvement of caveolin-1 (CAV1) within the caveolae in atherosclerosis development has been consistently supported.
Li Wang +10 more
doaj +4 more sources
Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner. [PDF]
PLoS ONE, 2017 Caveolae are abundant adipocyte surface domains involved in insulin signaling, membrane trafficking and lipid homeostasis. Transcriptional control mechanisms for caveolins and cavins, the building blocks of caveolae, are thus arguably important for ...
Björn Hansson +7 more
doaj +5 more sources
Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion. [PDF]
PLoS ONE, 2012 Caveolae, little caves of cell surfaces, are enriched in cholesterol, a certain level of which is required for their structural integrity. Here we show in adipocytes that cavin-2, a peripheral membrane protein and one of 3 cavin isoforms present in ...
Michael R Breen +4 more
doaj +6 more sources
Prognostic and diagnostic significance of Cavin 2 in lung adenocarcinoma. [PDF]
Arch Med Sci, 2020 Cavin 2 down-regulation is reported in several malignant tumors and is associated with tumor progression. However, the role of Cavin 2 in lung adenocarcinoma is unknown. This study aimed to investigate the prognostic and diagnostic significance of Cavin 2 in lung adenocarcinoma.Cavin 2 expression levels were examined in 150 cases of lung adenocarcinoma
Wang X +5 more
europepmc +3 more sources
Prognostic and Diagnostic Significance of SDPR-Cavin-2 in Hepatocellular Carcinoma [PDF]
Cellular Physiology and Biochemistry, 2016 Background: Hepatocellular carcinoma (HCC) is a malignant tumor worldwide. Due to the lack of early prediction marker, numerous patients were diagnosed in their late stage.
Wei Jing +5 more
doaj +3 more sources
Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis. [PDF]
J Biol Chem, 2017 Angiogenesis is a highly regulated process for formation of new blood vessels from pre-existing ones. Angiogenesis is dysregulated in various pathologies, including age-related macular degeneration, arthritis, and cancer. Inhibiting pathological angiogenesis therefore represents a promising therapeutic strategy for treating these disorders ...
Boopathy GTK +8 more
europepmc +5 more sources