Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation [PDF]
Molecular Metabolism, 2022 Objective: Adipogenesis plays an essential role in maintaining energy and hormonal balance. Cavin-2, one of the caveolae-related proteins, is abundant in adipocytes, the leading site of adipogenesis.
Takehiro Ogata +2 more
exaly +4 more sources
Cavin-2 loss exacerbates hypoxia-induced pulmonary hypertension with excessive eNOS phosphorylation and protein nitration [PDF]
Heliyon, 2023 Pulmonary hypertension (PH) is associated with a poor prognosis even in recent years. Caveolin-1 (CAV1), a caveolae-associated protein, is a causal gene in PH.
Takehiro Ogata +2 more
exaly +4 more sources
Cavin-2 Promotes Fibroblast-to-Myofibroblast Trans-Differentiation and Aggravates Cardiac Fibrosis [PDF]
ESC Heart FailureAims Transforming growth factor β (TGF‐β) signalling is one of the critical pathways in fibroblast activation, and several drugs targeting the TGF‐β/Smad signalling pathway in heart failure with cardiac fibrosis are being tested in clinical trials.
Takehiro Ogata
exaly +3 more sources
CAVIN-2 positively correlates with diabetic PAD and promotes LDL transcytosis by inhibiting eNOS activation [PDF]
Annals of MedicineObjective Caveolae are closely linked to the onset and progression of atherosclerosis. The pivotal involvement of caveolin-1 (CAV1) within the caveolae in atherosclerosis development has been consistently supported.
Li Wang +10 more
exaly +4 more sources
Revealing Cavin-2 Gene Function in Lung Based on Multi-Omics Data Analysis Method [PDF]
Frontiers in Cell and Developmental Biology, 2022 Research points out that it is particularly important to comprehensively evaluate immune microenvironmental indicators and gene mutation characteristics to select the best treatment plan.
Changsheng Li +5 more
doaj +2 more sources
Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner. [PDF]
PLoS ONE, 2017 Caveolae are abundant adipocyte surface domains involved in insulin signaling, membrane trafficking and lipid homeostasis. Transcriptional control mechanisms for caveolins and cavins, the building blocks of caveolae, are thus arguably important for ...
Björn Hansson +7 more
doaj +2 more sources
Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion. [PDF]
PLoS ONE, 2012 Caveolae, little caves of cell surfaces, are enriched in cholesterol, a certain level of which is required for their structural integrity. Here we show in adipocytes that cavin-2, a peripheral membrane protein and one of 3 cavin isoforms present in ...
Michael R Breen +4 more
doaj +2 more sources
Adversarial Erasing Enhanced Multiple Instance Learning (siMILe): Discriminative Identification of Oligomeric Protein Structures in Single Molecule Localization Microscopy. [PDF]
Adv Intell SystHallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Hallgrimson C +8 more
europepmc +2 more sources
SDPR-STK38 axis controls the proliferation-differentiation balance in alveolar type II cells. [PDF]
Animal Model Exp MedThe present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Wang J +6 more
europepmc +2 more sources
The β1 adrenoceptor (AR) blocker metoprolol normalises βAR cascade and caveolar protein expression and restores β1AR responsiveness in failing right ventricular myocytes [PDF]
Journal of Molecular and Cellular Cardiology PlusRight ventricular (RV) failure is the leading cause of death in pulmonary artery hypertension (PAH) and treatments that preserve RV contractility are urgently required.
Ruth Norman +5 more
doaj +2 more sources