Results 41 to 50 of about 2,142 (162)
Endocytic crosstalk: cavins, caveolins, and caveolae regulate clathrin-independent endocytosis.
PLoS Biology, 2014 Several studies have suggested crosstalk between different clathrin-independent endocytic pathways. However, the molecular mechanisms and functional relevance of these interactions are unclear.
Natasha Chaudhary +10 more
doaj +1 more source
The analysis of Cav1α function in Xenopus motoneuron outgrowth and neuromuscular integrity [PDF]
, 2020 Caveolin 1 (Cav1) is a versatile membrane protein that plays a role in the pathogenesis of hereditary lipodystrophy and neurodegenerative diseases such as Alzheimer. As an essential structural component of caveolae, specialized membrane invaginations, it
Breuer, Marlen
core +1 more source
Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix. [PDF]
, 2023 The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt and respond to them. PM invaginations named caveolae, with a specific protein and lipid composition, play a crucial role in this mechanosensing and mechanotransduction
del Pozo, Miguel Angel +2 more
core +1 more source
eLife, 2014 In mammalian cells three closely related cavin proteins cooperate with the scaffolding protein caveolin to form membrane invaginations known as caveolae.
Yann Gambin +18 more
doaj +1 more source
Caveolae: Metabolic Platforms at the Crossroads of Health and Disease. [PDF]
Int J Mol SciCaveolae are small flask-shaped invaginations of the plasma membrane enriched in cholesterol and sphingolipids. They play a critical role in various cellular processes, including signal transduction, endocytosis, and mechanotransduction.
Stea DM, D'Alessio A.
europepmc +3 more sources
Advanced Intelligent Systems, EarlyView.Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson +8 more
wiley +1 more source
SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells
Animal Models and Experimental Medicine, EarlyView.The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang +6 more
wiley +1 more source
Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice [PDF]
, 2020 Receptor-mediated endocytosis, which contributes to a wide range of cellular functions, including receptor signaling, cell adhesion, and migration, requires endocytic vesicle release by the large GTPase dynamin 2.
Adam D. Munday +4 more
core +2 more sources
The systemic deletion of interleukin-1α reduces myocardial inflammation and attenuates ventricular remodeling in murine myocardial infarction. [PDF]
, 2023 Myocardial inflammation following myocardial infarction (MI) is crucial for proper myocardial healing, yet, dysregulated inflammation may promote adverse ventricular remodeling and heart failure. IL-1 signaling contributes to these processes, as shown by
Cavin, S. +6 more
core +1 more source
Geological processes shaping freshwater biodiversity: a synthesis of global evidence
Biological Reviews, Volume 101, Issue 3, Page 1568-1581, June 2026.ABSTRACT Recent genomic data highlight the key roles of geological processes in shaping the diversification and biogeography of freshwater lineages. Specifically, physical processes such as tectonic uplift, erosion, glaciation, lake formation, and sea‐level fluctuation contribute extensively to the evolution of biotic diversity within and among ...
Jonathan M. Waters +3 more
wiley +1 more source