Results 41 to 50 of about 2,002 (125)

In Situ GWAS in Two Range‐Edge Populations of European Beech (Fagus sylvatica L.) Identify Genetic Factors of Adaptation to Climate Change

Molecular Ecology, Volume 35, Issue 15, August 2026.
ABSTRACT In forest tree populations, the timing of budbreak (TBB) depends on several factors, both environmental and genetic. The genomic architecture underlying this trait is still not fully characterized. So far, common garden experiments have highlighted a few genomic regions with little heritability, while the whole spectrum of TBB variation ...
Lauren Clément, Andrea Modica, Isabelle Lesur Kupin, Christophe Plomion, Catherine Bodénès, Grégoire Le Provost, Sylvie Oddou‐Muratorio, Katrin Heer, Marie Mirouze, Marie‐Christine Carpentier, Bartosz Ulaszewski, William Marande, Jean‐Marc Aury, Simone Duprat, Corinne da Silva, Benjamin Noel, Corinne Cruaud, Karine Labadie, Joëlle Amselem, Johann Confais, Hadi Quesneville, Jean‐André Magdalou, Olivier Panaud, Ivan Scotti   +23 more
wiley   +1 more source

Caveolae, caveolins, cavins and endothelial cell function: new insights

Frontiers in Physiology, 2012
Caveolae are cholesterol and glycosphingolipid-rich flask-shaped invaginations of the plasma membrane which are particularly abundant in vascular endothelium and present in all other cell types of the cardiovascular system, including vascular smooth ...
Grzegorz eSowa
doaj   +1 more source

Adversarial Erasing Enhanced Multiple Instance Learning (siMILe): Discriminative Identification of Oligomeric Protein Structures in Single Molecule Localization Microscopy

Advanced Intelligent Systems, Volume 8, Issue 7, July 2026.
Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson, Y. Lydia Li, Claire A. Shou, Ben Cardoen, John Lim, Timothy H. Wong, Ismail M. Khater, Ivan Robert Nabi, Ghassan Hamarneh   +8 more
wiley   +1 more source

The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding

Communications Biology
Caveolin-1 (CAV1) and Cavin-1 are components of caveolae, both of which interact with and influence the composition and stabilization of caveolae. CAV1 is associated with pulmonary arterial hypertension (PAH).
Shinya Tomita, Naohiko Nakanishi, Takehiro Ogata, Yusuke Higuchi, Akira Sakamoto, Yumika Tsuji, Takaomi Suga, Satoaki Matoba   +7 more
doaj   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/Cavin‐4 Deletion Against Ischemia/Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Ischemia/reperfusion (I/R) injury is a critical issue in the development of treatment strategies for ischemic heart disease. MURC (muscle‐restricted coiled‐coil protein)/Cavin‐4 (caveolae‐associated protein 4), which is a component of caveolae,
Masahiro Nishi, Takehiro Ogata, Carlo Vittorio Cannistraci, Sara Ciucci, Naohiko Nakanishi, Yusuke Higuchi, Akira Sakamoto, Yumika Tsuji, Katsura Mizushima, Satoaki Matoba   +9 more
doaj   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Digital speech‐based markers to advance prognosis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Validated prognostic tools are essential to advance drug development and clinical care in Alzheimer's disease, particularly as the field shifts toward the prevention of cognitive decline. While progress has been made in developing blood‐based biomarkers for the early detection of amyloid pathology, amyloid positivity alone does not reliably ...
Melissa Lee, Stephan Meylan, Eli Shobin, the SpeechDx Consortium, Laura Nisenbaum, Aishwarya Sukumar, Lampros Kourtis   +6 more
wiley   +1 more source

Geological processes shaping freshwater biodiversity: a synthesis of global evidence

Biological Reviews, Volume 101, Issue 3, Page 1568-1581, June 2026.
ABSTRACT Recent genomic data highlight the key roles of geological processes in shaping the diversification and biogeography of freshwater lineages. Specifically, physical processes such as tectonic uplift, erosion, glaciation, lake formation, and sea‐level fluctuation contribute extensively to the evolution of biotic diversity within and among ...
Jonathan M. Waters, Christopher P. Burridge, David Craw, James S. Albert   +3 more
wiley   +1 more source

Shaping future forests: how can ecophysiology support climate‐smart forest management?

New Phytologist, Volume 250, Issue 5, Page 2778-2813, June 2026.
Summary Climate change, particularly the associated increase in extreme events and disturbances, threatens the numerous environmental, social, and economic benefits that forests provide, both locally and globally. Heat and drought pose significant risks to forest ecosystems; the anticipated future climate is expected to exacerbate this trend ...
Arthur Gessler, José M. Grünzweig, Laura Bigio, Henrik Hartmann, Nate McDowell, Frank Krumm, Arun K. Bose, Andreas Rigling, Harald Bugmann, Valentina Vitali, Pascal Schneider, J. Jelle Lever, Janine Schweier, Anne Kempel, Niklaus E. Zimmermann, Philipp Brun, Jürgen Bauhus, Micah Wilhelm, Alessandra Bottero   +18 more
wiley   +1 more source