Results 21 to 30 of about 2,142 (162)

Hypoxia Inhibits Cavin-1 and Cavin-2 Expression and Down-Regulates Caveolae in Adipocytes [PDF]

Endocrinology, 2015
AbstractDuring obesity, a hypoxic state develops within the adipose tissue, resulting in insulin resistance. To understand the underlying mechanism, we analyzed the involvement of caveolae because they play a crucial role in the activation of insulin receptors.
Regazzetti, Claire, Dumas, Karine, Lacas-Gervais, Sandra, Pastor, Faustine, Peraldi, Pascal, Bonnafous, Stéphanie, Dugail, Isabelle, Le Lay, Soazig, Valet, Philippe, Le Marchand-Brustel, Yannick, Tran, Albert, Gual, Philippe, Tanti, Jean-François, Cormont, Mireille, Giorgetti-Peraldi, Sophie   +14 more
openaire   +2 more sources

Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice. [PDF]

PLoS ONE, 2014
Caveolae are omega-shaped plasma membrane micro-domains that are abundant in cells of the vascular system. Formation of caveolae depends on caveolin-1 and cavin-1 and lack of either protein leads to loss of caveolae.
Karl Swärd, Sebastian Albinsson, Catarina Rippe   +2 more
doaj   +1 more source

Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. [PDF]

PLoS Genetics, 2010
We investigated eight families with a novel subtype of congenital generalized lipodystrophy (CGL4) of whom five members had died from sudden cardiac death during their teenage years. ECG studies revealed features of long-QT syndrome, bradycardia, as well
Anna Rajab, Volker Straub, Liza J McCann, Dominik Seelow, Raymonda Varon, Rita Barresi, Anne Schulze, Barbara Lucke, Susanne Lützkendorf, Mohsen Karbasiyan, Sebastian Bachmann, Simone Spuler, Markus Schuelke   +12 more
doaj   +1 more source

Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity [PDF]

, 2011
Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null ...
Aboulaich, Bastiani, Bastiani, Berger, Brasaemle, Brasaemle, Cao, Cohen, Cohen, Dietl, Ducharme, Dwianingsih, El-Jack, Gauthier, Green, Guilherme, Hansen, Hansen, Hayashi, Hill, Kandror, Kim, Le Lay, Libin Liu, Liu, Liu, McMahon, Meshulam, Michael R. Breen, Ost, Parolini, Paul F. Pilch, Pilch, Pilch, Rajab, Robert G. Parton, Shastry, Simard, Simons, Souto, Stralfors, Thorn, Todaro, Tova Meshulam, Wang, Williams, Zechner   +46 more
core   +1 more source

PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis. [PDF]

PLoS ONE, 2016
Mutations in the PTRF/Cavin-1 gene cause congenital generalized lipodystrophy type 4 (CGL4) associated with myopathy. Additionally, long-QT syndrome and fatal cardiac arrhythmia are observed in patients with CGL4 who have homozygous PTRF/Cavin-1 ...
Takuya Taniguchi, Naoki Maruyama, Takehiro Ogata, Takeru Kasahara, Naohiko Nakanishi, Kotaro Miyagawa, Daisuke Naito, Tetsuro Hamaoka, Masahiro Nishi, Satoaki Matoba, Tomomi Ueyama   +10 more
doaj   +1 more source

Immune Priming and the Risk of COVID-19, Influenza, and Other Acute Respiratory Infections: Insights From an N3C Cohort. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background The emergence of SARS‐CoV‐2 and introduction of COVID‐19 vaccines into immunologically naïve populations may alter the dynamics of other acute viral respiratory infections (viral ARIs) and vice versa. Competing forces, including viral interference, cross‐reactive immunity, shared susceptibility, and immune dysregulation, may affect ...
León TM, Muehling LM, Baccile R, Morozova O, National Clinical Cohort Collaborative (N3C) COVID‐19 Consortium.   +4 more
europepmc   +2 more sources

SDPR/Cavin-2 loss inhibits monocyte adhesion to endothelial cells in abdominal aortic aneurysm via suppressing the expression of adhesion molecules [PDF]

European Heart Journal, 2020
Abstract Background Abdominal aortic aneurysm (AAA) is a common and life-threatening vascular disease. The initial phase of AAA progression is vascular inflammation. Inflammation sites present adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intracellular cell adhesion ...
A Sakamoto, T Ogata, N Nakanishi, Y Higuchi, Y Tsuji, S Tomita, S Matoba   +6 more
openaire   +1 more source

Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation [PDF]

, 2012
Caveolin-1 (Cav1) is an essential component of caveolae whose Src kinase-dependent phosphorylation on tyrosine 14 (Y14) is associated with regulation of focal adhesion dynamics.
Bastiani, Bharat Joshi, Cao, Cao, Cecile Boscher, Chen, Dasari, Day, del Pozo, Fielding, Gaus, Glenney, Glenney, Goetz, Grande-García, Hansen, Hill, Huang, Huang, Ivan R. Nabi, Jaffe, Jain, Joshi, Joshi, Kim, Kirkham, Kojic, Kubosaki, Kurzchalia, Lee, Li, Liu, Mastick, McMahon, Michele Bastiani, Nose, Orlichenko, Orlichenko, Paszek, Radel, Raychowdhury, Robert G. Parton, Rothberg, Scott S. Strugnell, Shankar, Shingu, Silverman, Sinha, Srivastava, Stula, Sun, Volonte, Volonté, Wu, Yu   +54 more
core   +1 more source

Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders [PDF]

, 2016
The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases ...
Aggarwal, M., Brozovich, F. V., Degen, C. V., Gao, Yuan Z., Morgan, K. G., Nicholson, C. J.   +5 more
core   +1 more source

Evaluation of the dystrophin carboxy-terminal domain for micro-dystrophin gene therapy in cardiac and skeletal muscles in the DMDmdx rat model [PDF]

, 2022
Duchenne muscular dystrophy (DMD) is a muscle wasting disorder caused by mutations in the gene encoding dystrophin. Gene therapy using micro-dystrophin (MD) transgenes and recombinant adeno-associated virus (rAAV) vectors hold great promise.
Adjali, Oumeya, Allais, Marine, Anegon, Ignacio, Blouin, Véronique, Bourdon, Audrey, Creismeas, Anna, Dickson, George, François, Virginie, Fraysse, Bodvael, Girard, Tiphaine, Guguin, Justine, Hivonnait, Agnès, Huchet, Corinne, Kao, Betty, Lafoux, Aude, Larcher, Thibaut, Le Guiner, Caroline, Le Heron, Anita, Lebreton, Cyrielle, Ledevin, Mireille, Malerba, Alberto, Marie, Basile, Montanaro, Federica, Moullier, Philippe, Popplewell, Linda, Remy, Séverine, Toumaniantz, Gilles, Zhang, Liwen   +27 more
core   +4 more sources