mBio, 2020 Listeria monocytogenes moves from one cell to another using actin-rich membrane protrusions that propel the bacterium toward neighboring cells. Despite cholesterol being required for this transfer process, the precise host internalization mechanism ...
Aaron S. Dhanda +10 more
doaj +6 more sources
Cavin-2 Functions as a Suppressive Regulator in TNF-induced Mesenchymal Stromal Cell Inflammation and Angiogenic Phenotypes. [PDF]
Int J Stem Cells, 2017 Tumour necrosis factor (TNF)-α activation of mesenchymal stromal cells (MSC) enhances their tumour-suppressive properties and tumour-homing ability. The molecular actors involved are unknown. We found that TNF induced MSC migration and tubulogenesis which correlated with a dose-dependent increase in Cavin-1 and Cavin-3 transcript levels.
Annabi B, Zgheib A, Annabi B.
europepmc +4 more sources
Pathophysiological Role of Caveolae in Hypertension [PDF]
Frontiers in Medicine, 2019 Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1–4, EHD2, pacsin2, and dynamin 2.
Xiaoming Lian +5 more
doaj +4 more sources
Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer [PDF]
BMC CancerCaveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable
Kelin Mou +12 more
doaj +2 more sources
The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding [PDF]
Communications BiologyCaveolin-1 (CAV1) and Cavin-1 are components of caveolae, both of which interact with and influence the composition and stabilization of caveolae. CAV1 is associated with pulmonary arterial hypertension (PAH).
Shinya Tomita +7 more
doaj +2 more sources
SDPR expression in human trabecular meshwork and its potential role in racial disparities of glaucoma [PDF]
Scientific ReportsIn order to identify how differential gene expression in the trabecular meshwork (TM) contributes to racial disparities of caveolar protein expression, TM dysfunction and development of primary open angle glaucoma (POAG), RNA sequencing was performed to ...
Ying-Bo Shui +3 more
doaj +3 more sources
Exosome-Based Cartilage-Targeted Delivery System: Strategies and Applications. [PDF]
Small SciConstruction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Wang Y, Chen B, Zhu H, Sun Z.
europepmc +2 more sources
Frontiers in Pediatrics, 2022 BackgroundCaveolae are plasma membrane subdomains of many mammalian cells that play critical roles in cellular processes, including endocytosis, signal transduction and tumorigenesis.
Jing Yang +7 more
doaj +1 more source
Role of Caveolae family-related proteins in the development of breast cancer
Frontiers in Molecular Biosciences, 2023 Breast cancer has become the most significant malignant tumor threatening women’s lives. Caveolae are concave pits formed by invagination of the plasma membrane that participate in many biological functions of the cell membrane, such as endocytosis, cell
Qinyu Han +4 more
doaj +1 more source
Proteomic analysis identifies key differences in the cardiac interactomes of dystrophin and micro-dystrophin [PDF]
, 2021 ΔR4-R23/ΔCT micro-dystrophin (μDys) is a miniaturized version of dystrophin currently evaluated in a Duchenne muscular dystrophy (DMD) gene therapy trial to treat skeletal and cardiac muscle disease.
Adams, ME +13 more
core +1 more source