Prognostic and Diagnostic Significance of SDPR-Cavin-2 in Hepatocellular Carcinoma
Cellular Physiology and Biochemistry, 2016 Background: Hepatocellular carcinoma (HCC) is a malignant tumor worldwide. Due to the lack of early prediction marker, numerous patients were diagnosed in their late stage.
Wei Jing +5 more
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PLoS ONE, 2014 The cavins are a family of proteins associated with caveolae, cavin-1, -2 and -3 being widely expressed while cavin-4 is restricted to striated muscle.
Libin Liu +4 more
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Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer [PDF]
BMC CancerCaveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable
Kelin Mou +12 more
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TRIM59 Drives Bladder Cancer Progression Through E3 Ligase-Dependent K48-Linked Degradation of PTRF. [PDF]
Cancer SciSchematic model of TRIM59‐driven BLCA progression through K48‐linked ubiquitination and proteasomal degradation of PTRF, leading to AKT activation and c‐Myc upregulation. ABSTRACT Tripartite motif‐containing 59 (TRIM59) is an E3 ubiquitin ligase implicated in multiple malignancies, but its role in bladder cancer (BLCA) remains incompletely understood ...
Gan J +9 more
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Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis. [PDF]
J Biol Chem, 2017 Angiogenesis is a highly regulated process for formation of new blood vessels from pre-existing ones. Angiogenesis is dysregulated in various pathologies, including age-related macular degeneration, arthritis, and cancer.
Boopathy GTK +8 more
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Frontiers in Pediatrics, 2022 BackgroundCaveolae are plasma membrane subdomains of many mammalian cells that play critical roles in cellular processes, including endocytosis, signal transduction and tumorigenesis.
Jing Yang +7 more
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Role of Caveolae family-related proteins in the development of breast cancer
Frontiers in Molecular Biosciences, 2023 Breast cancer has become the most significant malignant tumor threatening women’s lives. Caveolae are concave pits formed by invagination of the plasma membrane that participate in many biological functions of the cell membrane, such as endocytosis, cell
Qinyu Han +4 more
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Interview with Amanda Cavin - OH 650 [PDF]
, 2021 This interview was conducted for the as part of the 20th Anniversary of the September 11th Terrorist Attacks on the United States. This effort was to produce a history of the university’s, as well as the community’s, response in the days and weeks ...
Cavin, Amanda
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Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice. [PDF]
PLoS ONE, 2014 Caveolae are omega-shaped plasma membrane micro-domains that are abundant in cells of the vascular system. Formation of caveolae depends on caveolin-1 and cavin-1 and lack of either protein leads to loss of caveolae.
Karl Swärd +2 more
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Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. [PDF]
PLoS Genetics, 2010 We investigated eight families with a novel subtype of congenital generalized lipodystrophy (CGL4) of whom five members had died from sudden cardiac death during their teenage years. ECG studies revealed features of long-QT syndrome, bradycardia, as well
Anna Rajab +12 more
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