Results 11 to 20 of about 2,002 (125)

Cavin-2 Functions as a Suppressive Regulator in TNF-induced Mesenchymal Stromal Cell Inflammation and Angiogenic Phenotypes. [PDF]

Int J Stem Cells, 2017
Tumour necrosis factor (TNF)-α activation of mesenchymal stromal cells (MSC) enhances their tumour-suppressive properties and tumour-homing ability. The molecular actors involved are unknown. We found that TNF induced MSC migration and tubulogenesis which correlated with a dose-dependent increase in Cavin-1 and Cavin-3 transcript levels.
Annabi B, Zgheib A, Annabi B.
europepmc   +4 more sources

Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer [PDF]

BMC Cancer
Caveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable
Kelin Mou, Huan Wang, Siqi Zhu, Jing Luo, Jianmei Wang, Lin Peng, Yulin Lei, Yunke Zhang, Shike Huang, Huarong Zhao, Gang Li, Li Xiang, Yuhao Luo   +12 more
doaj   +2 more sources

Expression of the Cavin Family in Childhood Leukemia and Its Implications in Subtype Diagnosis and Prognosis Evaluation

Frontiers in Pediatrics, 2022
BackgroundCaveolae are plasma membrane subdomains of many mammalian cells that play critical roles in cellular processes, including endocytosis, signal transduction and tumorigenesis.
Jing Yang, Junbin Huang, Huabin Wang, Yong Liu, Yanlai Tang, Chao Lin, Qin Zhou, Chun Chen   +7 more
doaj   +1 more source

Role of Caveolae family-related proteins in the development of breast cancer

Frontiers in Molecular Biosciences, 2023
Breast cancer has become the most significant malignant tumor threatening women’s lives. Caveolae are concave pits formed by invagination of the plasma membrane that participate in many biological functions of the cell membrane, such as endocytosis, cell
Qinyu Han, Shi Qiu, Huiwen Hu, Wenjing Li, Xiangqi Li   +4 more
doaj   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies. [PDF]

Traffic
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Frisby D, Misri G, Naslavsky N, Caplan S.   +3 more
europepmc   +2 more sources

Hypoxia Inhibits Cavin-1 and Cavin-2 Expression and Down-Regulates Caveolae in Adipocytes [PDF]

Endocrinology, 2015
AbstractDuring obesity, a hypoxic state develops within the adipose tissue, resulting in insulin resistance. To understand the underlying mechanism, we analyzed the involvement of caveolae because they play a crucial role in the activation of insulin receptors.
Regazzetti, Claire, Dumas, Karine, Lacas-Gervais, Sandra, Pastor, Faustine, Peraldi, Pascal, Bonnafous, Stéphanie, Dugail, Isabelle, Le Lay, Soazig, Valet, Philippe, Le Marchand-Brustel, Yannick, Tran, Albert, Gual, Philippe, Tanti, Jean-François, Cormont, Mireille, Giorgetti-Peraldi, Sophie   +14 more
openaire   +2 more sources

Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice. [PDF]

PLoS ONE, 2014
Caveolae are omega-shaped plasma membrane micro-domains that are abundant in cells of the vascular system. Formation of caveolae depends on caveolin-1 and cavin-1 and lack of either protein leads to loss of caveolae.
Karl Swärd, Sebastian Albinsson, Catarina Rippe   +2 more
doaj   +1 more source

Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. [PDF]

PLoS Genetics, 2010
We investigated eight families with a novel subtype of congenital generalized lipodystrophy (CGL4) of whom five members had died from sudden cardiac death during their teenage years. ECG studies revealed features of long-QT syndrome, bradycardia, as well
Anna Rajab, Volker Straub, Liza J McCann, Dominik Seelow, Raymonda Varon, Rita Barresi, Anne Schulze, Barbara Lucke, Susanne Lützkendorf, Mohsen Karbasiyan, Sebastian Bachmann, Simone Spuler, Markus Schuelke   +12 more
doaj   +1 more source

SDPR/Cavin-2 loss inhibits monocyte adhesion to endothelial cells in abdominal aortic aneurysm via suppressing the expression of adhesion molecules [PDF]

European Heart Journal, 2020
Abstract Background Abdominal aortic aneurysm (AAA) is a common and life-threatening vascular disease. The initial phase of AAA progression is vascular inflammation. Inflammation sites present adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intracellular cell adhesion ...
A Sakamoto, T Ogata, N Nakanishi, Y Higuchi, Y Tsuji, S Tomita, S Matoba   +6 more
openaire   +1 more source

PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis. [PDF]

PLoS ONE, 2016
Mutations in the PTRF/Cavin-1 gene cause congenital generalized lipodystrophy type 4 (CGL4) associated with myopathy. Additionally, long-QT syndrome and fatal cardiac arrhythmia are observed in patients with CGL4 who have homozygous PTRF/Cavin-1 ...
Takuya Taniguchi, Naoki Maruyama, Takehiro Ogata, Takeru Kasahara, Naohiko Nakanishi, Kotaro Miyagawa, Daisuke Naito, Tetsuro Hamaoka, Masahiro Nishi, Satoaki Matoba, Tomomi Ueyama   +10 more
doaj   +1 more source