Results 21 to 30 of about 7,336 (225)

Caveolae-Associated Protein 3 (Cavin-3) Influences Adipogenesis via TACE-Mediated Pref-1 Shedding [PDF]

International Journal of Molecular Sciences, 2020
Abnormal adipogenesis regulation is accompanied by a variety of metabolic dysfunctions and disorders. Caveolae play an important role in the regulation of fat production, modulated by caveolae-associated proteins (Cavin-1 to 4). Here, we investigated the
Sung Tae Kim, Phil June Park, Kim Sung Tae   +2 more
exaly   +3 more sources

Cavin-3 dictates the balance between ERK and Akt signaling [PDF]

eLife, 2013
Cavin-3 is a tumor suppressor protein of unknown function. Using both in vivo and in vitro approaches, we show that cavin-3 dictates the balance between ERK and Akt signaling.
Victor J Hernandez, Jian Weng, Peter Ly, Shanica Pompey, Hongyun Dong, Lopa Mishra, Margaret Schwarz, Richard GW Anderson, Peter Michaely   +8 more
doaj   +4 more sources

Expression of the Cavin Family in Childhood Leukemia and Its Implications in Subtype Diagnosis and Prognosis Evaluation

Frontiers in Pediatrics, 2022
BackgroundCaveolae are plasma membrane subdomains of many mammalian cells that play critical roles in cellular processes, including endocytosis, signal transduction and tumorigenesis.
Jing Yang, Junbin Huang, Huabin Wang, Yong Liu, Yanlai Tang, Chao Lin, Qin Zhou, Chun Chen   +7 more
doaj   +2 more sources

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes [PDF]

Journal of Cell Biology, 2009
Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds ...
Bastiani, Michele, Hill, Michelle M., Nixon, Susan J., Lo, Harriet P., Abankwa, Daniel, Luetterforst, Robert, Fernandez-Rojo, Manuel, Breen, Michael R., Vinten, Jorgen, Walser, Piers J., North, Kathryn N., Hancock, John F., Pilch, Paul F., Parton, Robert G., Liu, Libin, Jedrychowski, Mark, Gygi, Steven   +16 more
openaire   +9 more sources

Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle [PDF]

Cell and Tissue Research, 2017
Cavins belong to a family of proteins that contribute to the formation of caveolae, which are membrane organelles with functional roles in muscle and fat.
Catarina Rippe, Baoyi Zhu, Karl Sward
exaly   +4 more sources

Revealing Cavin-2 Gene Function in Lung Based on Multi-Omics Data Analysis Method

Frontiers in Cell and Developmental Biology, 2022
Research points out that it is particularly important to comprehensively evaluate immune microenvironmental indicators and gene mutation characteristics to select the best treatment plan.
Changsheng Li, Jingyu Huang, Hexiao Tang, Bing Liu, Bing Liu, Xuefeng Zhou   +5 more
doaj   +2 more sources

Lessons from cavin-1 deficiency [PDF]

Biochemical Society Transactions, 2020
Caveolae have been implicated in a wide range of critical physiological functions. In the past decade, the dominant role of cavin-1 in caveolae formation has been established, and it has been recognized as another master regulator for caveolae biology ...
Libin Liu
semanticscholar   +3 more sources

Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer [PDF]

BMC Cancer
Caveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable
Kelin Mou, Huan Wang, Siqi Zhu, Jing Luo, Jianmei Wang, Lin Peng, Yulin Lei, Yunke Zhang, Shike Huang, Huarong Zhao, Gang Li, Li Xiang, Yuhao Luo   +12 more
doaj   +2 more sources

Downregulation of Cavin‐1 Expression via Increasing Caveolin‐1 Degradation Prompts the Proliferation and Migration of Vascular Smooth Muscle Cells in Balloon Injury–Induced Neointimal Hyperplasia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPercutaneous coronary intervention has been widely used in the treatment of ischemic heart disease, but vascular restenosis is a main limitation of percutaneous coronary intervention.
Li‐Jun Zhou, Xue‐Ying Chen, Shui‐Ping Liu, Lin‐Lin Zhang, Ya‐Nan Xu, Pan‐Wei Mu, Deng‐Feng Geng, Zhi Tan   +7 more
doaj   +2 more sources

PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis. [PDF]

PLoS ONE, 2016
Mutations in the PTRF/Cavin-1 gene cause congenital generalized lipodystrophy type 4 (CGL4) associated with myopathy. Additionally, long-QT syndrome and fatal cardiac arrhythmia are observed in patients with CGL4 who have homozygous PTRF/Cavin-1 ...
Takuya Taniguchi, Naoki Maruyama, Takehiro Ogata, Takeru Kasahara, Naohiko Nakanishi, Kotaro Miyagawa, Daisuke Naito, Tetsuro Hamaoka, Masahiro Nishi, Satoaki Matoba, Tomomi Ueyama   +10 more
doaj   +2 more sources