Introduction of caveolae structural proteins into the protozoan Toxoplasma results in the formation of heterologous caveolae but not caveolar endocytosis. [PDF]
PLoS ONE, 2012 Present on the plasma membrane of most metazoans, caveolae are specialized microdomains implicated in several endocytic and trafficking mechanisms. Caveolins and the more recently discovered cavins are the major protein components of caveolae.
Bao Lige +5 more
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SnapShot: Caveolae, Caveolins, and Cavins
Cell, 2013 Caveolae, submicroscopic bulb-shaped plasma membrane pits, are an abundant feature of many mammalian cells (Parton and del Pozo, 2013). Caveolae and the major proteins of caveolae, caveolins (Rothberg et al., 1992), and cavins (Hill et al., 2008), are linked to a number of human diseases such as muscular dystrophy, cardiomyopathy, and lipodys -trophy ...
Ariotti, Nicholas, Parton Robert G.
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Caveolin-1 expression and cavin stability regulate caveolae dynamics in adipocyte lipid store fluctuation [PDF]
, 2014 Adipocytes specialized in the storage of energy as fat are among the most caveolae-enriched cell types. Loss of caveolae produces lipodystrophic diabetes in humans, which cannot be reversed by endothelial rescue of caveolin expression in mice, indicating
C. Prado +8 more
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Sharks, Rays and a Chimaeroid from the Kimmeridgian (Late Jurassic) of Ringstead, Southern England [PDF]
, 2002 Sampling of a lenticular concentration of vertebrate debris and associated sediments from the lower Kimmeridgian of southern England has allowed the study of a diverse and abundant assemblage of chondrichthyan remains.
Underwood, Charlie J.
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Pleiotropic Effects of Cavin-1 Deficiency on Lipid Metabolism [PDF]
Journal of Biological Chemistry, 2014 Mice and humans lacking caveolae due to gene knock-out or inactivating mutations of cavin-1/PTRF have numerous pathologies including markedly aberrant fuel metabolism, lipodystrophy, and muscular dystrophy. We characterized the physiologic/metabolic profile of cavin-1 knock-out mice and determined that they were lean because of reduced white adipose ...
Shi-Ying, Ding +5 more
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A reappraisal of the Italian record of the Cretaceous pachycormid fish Protosphyraena Leidy, 1857 [PDF]
, 2017 The genus Protosphyraena is known mainly from partial remains, consisting of isolated blade-like teeth, conical rostra and scythe-like pectoral fins. This paper provides a new insight into partial specimens of the genus Protosphyraena from the Cretaceous
Amalfitano, Jacopo +3 more
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Acetylation of Cavin-1 Promotes Lipolysis in White Adipose Tissue [PDF]
Molecular and Cellular Biology, 2017 White adipose tissue (WAT) serves as a reversible energy storage depot in the form of lipids in response to nutritional status. Cavin-1, an essential component in the biogenesis of caveolae, is a positive regulator of lipolysis in adipocytes. However, molecular mechanisms of cavin-1 in the modulation of lipolysis remain poorly understood.
Shui-Rong, Zhou +12 more
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Pathophysiological Role of Caveolae in Hypertension [PDF]
, 2019 Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2.
Daumke, Oliver +4 more
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Caveolae and Lipid Rafts in Endothelium: Valuable Organelles for Multiple Functions
Biomolecules, 2020 Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell types and are particularly abundant in endothelial cells and adipocytes.
Antonio Filippini, Alessio D’Alessio
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Cavin family proteins and the assembly of caveolae
Journal of Cell Science, 2015 ABSTRACT Caveolae are an abundant feature of the plasma membrane in many cells. Until recently, they were generally considered to be membrane invaginations whose formation primarily driven by integral membrane proteins called caveolins. However, the past decade has seen the emergence of the cavin family of peripheral membrane proteins as
Kovtun, Oleksiy +4 more
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