Cellular spelunking: exploring adipocyte caveolae [PDF]
Journal of Lipid Research, 2007 It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous.
Paul F. Pilch +6 more
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Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix
Cells, 2023 The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt and respond to them. PM invaginations named caveolae, with a specific protein and lipid composition, play a crucial role in this mechanosensing and mechanotransduction
Laura Sotodosos-Alonso +2 more
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Current Biology, 2018 Caveolae are one of the most abundant and striking features of the plasma membrane of many mammalian cell types. These surface pits have fascinated biologists since their discovery by the pioneers of electron microscopy in the middle of the last century, but we are only just starting to understand their multiple functions.
Parton, Robert G +2 more
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Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP
Nature Communications, 2022 The translation of mechanical cues into gene expression changes is dependent on the nuclear import of mechanoresponsive transcriptional regulators. Here the authors identify that Importin-7 drives the nuclear import of one such regulator YAP while YAP ...
María García-García +12 more
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Nature Communications, 2022 Caveolae are small coated plasma membrane invaginations with diverse functions. Caveolae undergo curvature changes. Yet, it is unclear which proteins regulate this process. To address this gap, we develop a correlative stimulated emission depletion (STED)
Claudia Matthaeus +6 more
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Caveolar fatty acids and acylation of caveolin-1. [PDF]
PLoS ONE, 2013 Caveolae are cholesterol and sphingolipids rich subcellular domains on plasma membrane. Caveolae contain a variety of signaling proteins which provide platforms for signaling transduction.
Qian Cai +3 more
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Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion. [PDF]
PLoS ONE, 2012 Caveolae, little caves of cell surfaces, are enriched in cholesterol, a certain level of which is required for their structural integrity. Here we show in adipocytes that cavin-2, a peripheral membrane protein and one of 3 cavin isoforms present in ...
Michael R Breen +4 more
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Lipid accumulation controls the balance between surface connection and scission of caveolae
eLife, 2020 Caveolae are bulb-shaped invaginations of the plasma membrane (PM) that undergo scission and fusion at the cell surface and are enriched in specific lipids.
Madlen Hubert +6 more
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Introduction of caveolae structural proteins into the protozoan Toxoplasma results in the formation of heterologous caveolae but not caveolar endocytosis. [PDF]
PLoS ONE, 2012 Present on the plasma membrane of most metazoans, caveolae are specialized microdomains implicated in several endocytic and trafficking mechanisms. Caveolins and the more recently discovered cavins are the major protein components of caveolae.
Bao Lige +5 more
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Actin-Cytoskeleton Drives Caveolae Signaling to Mitochondria during Postconditioning
Cells, 2023 Caveolae-associated signaling toward mitochondria contributes to the cardioprotective mechanisms against ischemia-reperfusion (I/R) injury induced by ischemic postconditioning.
Francisco Correa +10 more
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