Results 71 to 80 of about 37,961 (284)

Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer. [PDF]

, 2019
Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. During leptospirosis, individuals are infected by contact with Leptospira-containing animal urine-contaminated water.
Fang, Jia-Qi, Hu, Wei-Lin, Li, Kai-Xuan, Li, Shi-Jun, Li, Yang, Lin, Xu'ai, Ojcius, David M, Yan, Jie   +7 more
core   +1 more source

Poliovirus transcytosis through M-like cells

Journal of General Virology, 2002
During the digestive-tract phase of infection, poliovirus (PV) is found in the oropharynx and the intestine. It has been proposed that PV enters the organism by crossing M cells, which are scattered in the epithelial sheet covering lymphoid follicles of Peyer’s patches. However, PV translocation through M cells has never been demonstrated. A model of M-
Ouzilou, Laurent, Caliot, Elise, Pelletier, Isabelle, Prévost, Marie-Christine, Pringault, Eric, Colbère-Garapin, Florence   +5 more
openaire   +3 more sources

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. [PDF]

, 1998
We have investigated the controversial involvement of components of the SNARE (soluble N-ethyl maleimide-sensitive factor [NSF] attachment protein [SNAP] receptor) machinery in membrane traffic to the apical plasma membrane of polarized epithelial (MDCK)
Chapin, SJ, Kömüves, LG, Low, SH, Mostov, KE, Weimbs, T, Whiteheart, SW, Wimmer, C   +6 more
core  

Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]

, 2015
Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine, Ramachandran, Roshni, Yaksh, Tony L   +2 more
core   +2 more sources

Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1

Journal of Lipid Research
Atherosclerosis results from the deposition and oxidation of LDL and immune cell infiltration in the sub-arterial space leading to arterial occlusion. Studies have shown that transcytosis transports circulating LDL across endothelial cells lining blood ...
K. Fung, Tse Wing Winnie Ho, Zizhen Xu, Dante Neculai, Catherine A. A. Beauchemin, Warren L. Lee, G. Fairn   +6 more
semanticscholar   +1 more source

Non‐Invasive Brain Targeted Delivery of Cannabidiol for Alleviating Neuroinflammatory Disease

Advanced Materials, EarlyView.
The glucose‐functionalized nanoparticles (GNPs) are developed for the brain‐targeted delivery of cannabidiol (CBD). GNPs bypass the blood‐brain barrier (BBB) via glucose transporter‐1 (GLUT‐1) and release CBD in response to reactive oxygen species (ROS).
Yibin Wang, Yundong Li, Xin Wang, Yaning Hou, Wei Deng, Meng Zheng, Yan Zou, Bingyang Shi   +7 more
wiley   +1 more source

Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting [PDF]

, 2000
PURPOSE: To prepare polymeric vesicles and niosomes bearing glucose or transferrin ligands for drug targeting. METHODS: A glucose-palmitoyl glycol chitosan (PGC) conjugate was synthesised and glucose-PGC polymeric vesicles prepared by sonication of ...
Couet, W., Dufès, Christine, Gray, A.I., Olivier, J.C., Schätzlein, A.G., Tetley, L., Uchegbu, I.F., Watson, D.G.   +7 more
core   +1 more source

Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis

Fluids and Barriers of the CNS, 2022
Traumatic brain injury (TBI) provokes secondary pathological damage, such as damage to the blood–brain barrier (BBB), ischaemia and inflammation. Major facilitator superfamily domain-containing 2a (Mfsd2a) has been demonstrated to be critical in limiting
Yuan Zhang, Lin Wang, Qiuling Pan, Xiaomin Yang, Yu Cao, Jinjin Yan, Yingwen Wang, Yihao Tao, Runjin Fan, Xiaochuan Sun, Lin Li   +10 more
semanticscholar   +1 more source

Bacterial Transcytosis across Conjunctival M Cells

Investigative Opthalmology & Visual Science, 2007
Antigen-sampling M cells have been identified in conjunctival tissue overlying lymphoid follicles in rabbits and guinea pigs. Conjunctival M cells in the guinea pig display alpha(2-3) sialic acid on their surfaces, as evinced by selective labeling by Maackia amurensis leukoagglutinin (MAL)-I.
Carisa K, Petris, Miriam, Golomb, Thomas E, Phillips   +2 more
openaire   +2 more sources