Results 81 to 90 of about 23,538 (242)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Scientific Reports
Transferrin Receptor (TfR)-mediated transcytosis across the blood-brain barrier (BBB) enables the uptake of bispecific therapeutic antibodies into the brain.
Inga Petersen, Jamie I. Morrison, Alex Petrovic, Neira Babic, Nicole G. Metzendorf, Ana Godec, Andrés de la Rosa, Fadi Rofo, Sina Bondza, Jos Buijs, Farahnaz Ranjbarian, Anders Hofer, Dag Sehlin, Greta Hultqvist   +13 more
doaj   +1 more source

Major effect of transcytosis on nano drug delivery to pancreatic cancer

Molecular & Cellular Oncology, 2017
We demonstrated that activated transcytosis is a major mechanism to complement the classic enhanced permeability and retention effect in pancreatic cancer.
Xiangsheng Liu, Jinhong Jiang, Andre E. Nel, Huan Meng   +3 more
doaj   +1 more source

The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals

Frontiers in Immunology, 2020
The gut is an efficient barrier which protects against the passage of pathogenic microorganisms and potential harmful macromolecules into the body, in addition to its primary function of nutrient digestion and absorption.
Björn Weström, Ester Arévalo Sureda, Kateryna Pierzynowska, Kateryna Pierzynowska, Stefan G. Pierzynowski, Stefan G. Pierzynowski, Francisco-José Pérez-Cano, Francisco-José Pérez-Cano   +7 more
doaj   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

IgG1 competes with IgG4 for FcRn-mediated transcytosis in HUVECs.

, 2023
(A) Schematic showing a cross-sectional view of the Transwell system and corresponding mechanistic model representation of FcRn-mediated IgG4 and IgG1 transport through HUVEC. Left panel: Arrow indicates the direction of transfer (apical to basolateral).
Remziye E. Wessel (17350784), Sepideh Dolatshahi (11074617)   +1 more
core   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Stimulation of transcytosis of the polymeric immunoglobulin receptor by dimeric IgA

, 1994
The polymeric immunoglobulin receptor (pIgR) is transcytosed from the basolateral to the apical surface of polarized epithelial cells. We have previously shown that phosphorylation of Ser-664 in the cytoplasmic domain of the pIgR is a signal for its ...
Bomsel, Morgane, Casanova, James, Mostov, Keith, Song, Wenxia, Vaerman, Jean-Pierre   +4 more
core   +1 more source

A lipoprotein-containing particle is transferred from the serum across the mammary epithelium into the milk of lactating mice

Journal of Lipid Research, 2001
To investigate the role of low-density lipoprotein (LDL) in the delivery of cholesterol to the mammary gland during pregnancy and lactation, we examined the distribution of radioactivity from 125I-tyramine cellobiose-LDL injected into the tail vein of ...
Jenifer Monks, Patricia Uelmen Huey, Linda Hanson, Robert H. Eckel, Margaret C. Neville, Sean Gavigan   +5 more
doaj   +1 more source