Results 81 to 90 of about 37,961 (284)

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Caveolae-Mediated Transcytosis and Its Role in Neurological Disorders

Biomolecules
The blood–brain barrier (BBB) controls the flow of substances to maintain a homeostatic environment in the brain, which is highly regulated and crucial for the normal function of the central nervous system (CNS). Brain endothelial cells (bECs), which are
Kunjian Yang, Qian Li, Yushuang Ruan, Yuanpeng Xia, Zhi Fang   +4 more
doaj   +1 more source

The Recycling and Transcytotic Pathways for IgG Transport by FcRn are Distinct and Display an Inherent Polarity [PDF]

, 2012
The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense.
Blumberg, Richard Steven, Frank, Scott Randy, Goldenring, James R., Hamman, Wendy, Hansen, Steen Henning, Lapierre, Lynne A., Lencer, Wayne Isaac, Massol, Ramiro, Tzaban, Salit, Yen, Elizabeth Hechavarria   +9 more
core   +1 more source

Insight into Cellular Uptake and Transcytosis of Peptide Nanoparticles in Spodoptera frugiperda Cells and Isolated Midgut

ACS Omega, 2022
Silencing genes in insects by introducing double-stranded RNA (dsRNA) in the diet holds promise as a new pest management method. It has been demonstrated that nanoparticles (NPs) can potentiate dsRNA silencing effects by promoting cellular ...
Erin McGraw, Jonathan D. Roberts, Nitish Kunte, M. Westerfield, Xavier Streety, D. Held, L. Avila   +6 more
semanticscholar   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Candida albicans colonization and dissemination from the murine gastrointestinal tract : the influence of morphology and Th17 immunity [PDF]

, 2014
This article is protected by copyright. All rights reserved. This work was supported by the Wellcome Trust (086558, 080088, 102705), a Wellcome Trust Strategic Award (097377) and a studentship from the University of Aberdeen. D.K.
Brown, Alistair J P, Brown, Gordon D, Chen, Kong, Drummond, Rebecca A, Gow, Neil A R, Kadosh, David, Kolls, Jay K, MacCallum, Donna M, Murray, Graeme I, Vautier, Simon   +9 more
core   +1 more source

Glycocalyx is critical for blood‐brain barrier integrity by suppressing caveolin1‐dependent endothelial transcytosis following ischemic stroke

Brain Pathology, 2021
The breakdown of the blood‐brain barrier (BBB) is related to the occurrence and deterioration of neurological dysfunction in ischemic stroke, which leads to the extravasation of blood‐borne substances, resulting in vasogenic edema and increased mortality.
Juan Zhu, Zheqi Li, Z. Ji, Yongming Wu, Yihua He, Kewei Liu, Yuan Chang, Yu Peng, Zhen-zhou Lin, Shengnan Wang, Dongmei Wang, Kaibin Huang, Suyue Pan   +12 more
semanticscholar   +1 more source

A Mitochondria‐Specific Nanomedicine for Synergistic Chemo‐Photothermal Therapy and Immunogenic Activation Against Breast Cancer

Advanced Science, EarlyView.
Peptide dendrimer–based nanoplatform with mitochondria‐targeting capability was developed for synergistic chemo‐photothermal therapy. The system promotes efficient transcytosis, induces mitochondrial dysfunction, triggers immunogenic cell death (ICD), and enhance antitumor immunity by promoting dendritic cell maturation and T‐cell activation, resulting
Min Li, Jiangqi Feng, Junyang Zhuang, Qingguo Zhong, Yanda Li, Yanzhuo Lv, Shaoteng Huang, Xiangyu Huang, Mingbo Zhang, Xiaofeng Cai, Yuxin Wang, Wenping Chen, Zhenyu Duan, Zhou Chen, Kui Luo, Ning Li   +15 more
wiley   +1 more source

Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells. [PDF]

, 1990
We studied the cell-surface delivery pathways of newly synthesized membrane glycoproteins in MDCK cells and for this purpose we characterized an endogenous apical integral membrane glycoprotein.
Le Bivic, A, Mostov, K, Rodriguez-Boulan, E, Sambuy, Y   +3 more
core  

Albumin nanoparticles for glutathione-responsive release of cisplatin: new opportunities for medulloblastoma treatment [PDF]

, 2016
Redox-responsive nanoparticles were synthesized by desolvation of bovine serum albumin followed by disulfide-bond crosslinking with N, Nʹ-Bis (acryloyl) cystamine. Dynamic light scattering and transmission electron microscopy studies revealed spherical
Abballe, Luana, Besharat, ZEIN MERSINI, Catanzaro, Giuseppina, Cirillo, Giuseppe, Curcio, Manuela, Ferretti, Elisabetta, Iemma, Francesca, Picci, Nevio, Spizzirri, Umile Gianfranco, Vacca, Alessandra   +9 more
core   +1 more source