Results 91 to 100 of about 23,538 (242)

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Transcytosis in MDCK cells: identification of glycoproteins transported bidirectionally between both plasma membrane domains. [PDF]

, 1990
MDCK cells display fluid-phase transcytosis in both directions across the cell. Transcytosis of cell surface molecules was estimated by electron microscopic analysis of streptavidin-gold-labeled frozen sections of biotinylated cells.
Parton, R. G., A W Brändli, R G Parton, Simons, K., Brandli, A. W., K Simons   +5 more
core   +1 more source

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

Neuronal Transcytosis of WGA Conjugated Protein

Neuronal transcytosis was observed at the stage when no neurotransmitter was released after the injection of wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP; WGA = 22 kDa, HRP = 40 kDa) into the vagus nerve.
Katsuhiko Warita, Jun-Qian Liu, Takanori Miki, Zhi-Yu Wang, Yoshiki Matsumoto, Tomiko Yakura, Yoshiki Takeuchi   +6 more
core   +1 more source

Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers [PDF]

, 2017
Bacterial viruses are among the most numerous biological entities within the human body. These viruses are found within regions of the body that have conventionally been considered sterile, including the blood, lymph, and organs.
Trevor Lithgow, Kyle Schlosser, Ruzeen Patwa, Nguyen, Sophie, Rohwer, Forest, Bailey, Barbara, Blumberg, Richard, Schlosser, Kyle, Barr, Jeremy J., Rhys A. Dunstan, Antoni Luque, Blumberg, Richard S., Lithgow, Trevor, Benjamin S. Padman, Dunstan, Rhys A., Barbara Bailey, Weston, Thomas A., Lazarou, Michael, Jeremy J. Barr, Thomas A. Weston, Sophie Nguyen, Richard S. Blumberg, Luque, Antoni, Forest Rohwer, Michael Lazarou, Baker, Kristi, Patwa, Ruzeen, Kristi Baker, Padman, Benjamin S.   +28 more
core   +1 more source

Lipid rafts ceramide and molecular transcytosis

Frontiers in Bioscience, 2016
Transcytosis, a widely described process concerning transport of macromolecules between the apical and basolateral sides in various cell types, is extremely important for multicellular organisms to selectively exchange materials in different microenvironments while maintaining cellular and body homeostasis.
Fang, Bian, Bin, Xiong, Xiaoyan, Yang, Si, Jin   +3 more
openaire   +2 more sources

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Chlamydial infection enhances expression of the polymeric immunoglobulin receptor (pIgR) and transcytosis of IgA [PDF]

, 2017
Problem\ud \ud The pIgR mediates transport of IgA into the lumen of mucosal tissues preventing pathogenic infection. Despite this, the expression of pIgR during chlamydial infections of the male and female reproductive tracts remains poorly understood ...
Beagley, Kenneth, Kenneth W. Beagley, Armitage, Charles W., Connor P. O'Meara, O'Meara, Connor, Charles W. Armitage   +5 more
core   +1 more source

Mechanisms of LDL Transcytosis during Basal and Inflammatory States [PDF]

Coronary artery disease is a leading cause of mortality worldwide. There is abundant literature concerning the late stages of its underlying cause, atherosclerosis, which is initiated by deposition of low-density lipoproteins (LDL) under the endothelium ...
Jang, Erika Lynn
core   +1 more source

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source