Results 101 to 110 of about 37,961 (284)

Hepatitis B virus translocates across a trophoblastic barrier [PDF]

, 2007
Mother-infant transmission of hepatitis B virus (HBV) accounts for up to 30% of worldwide chronic infections. The mechanism and high-risk period of HBV transmission from mother to infant are unknown.
Bhat, Purnima, Anderson, David A.
core   +1 more source

Smart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.

Chemical and pharmaceutical bulletin, 2020
Discriminatory drug delivery into target cells is essential to effectively elicit the drug activity and to avoid off-target side effects; however, transporting drugs across the cell membrane is difficult due to factors such as molecular size ...
T. Tashima
semanticscholar   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome

Journal of Neuroinflammation
Background It is well known that high-fat diet (HFD)-induced metabolic syndrome plays a crucial role in cognitive decline and brain-blood barrier (BBB) breakdown.
Guanqiao Liu, Wen Shu, Yingqi Chen, Yong Fu, Shuai Fang, Haonan Zheng, Weike Cheng, Qingrong Lin, Yanjun Hu, Nan Jiang, Bin Yu   +10 more
doaj   +1 more source

Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood–Brain Barrier

Pharmaceutics, 2014
The blood–brain barrier acts as a physical barrier that prevents free entry of blood-derived substances, including those intended for therapeutic applications.
Julia V. Georgieva, Dick Hoekstra, Inge S. Zuhorn   +2 more
doaj   +1 more source

Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

Science Advances, 2020
Wnt signaling pathway suppresses vascular endothelium transcytosis in the BRB through activating MFSD2A. Breakdown of the blood-retinal barrier (BRB) causes retinal edema and vision loss.
Zhongxiao Wang, Chi-Hsiu Liu, Shuo Huang, Z. Fu, Yohei Tomita, William R. Britton, Steve S. Cho, Chuck T. Chen, Ye Sun, Jian-xing Ma, Xi He, J. Chen   +11 more
semanticscholar   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Active Transport of Peptides Across the Intact Human Tympanic Membrane. [PDF]

, 2018
We previously identified peptides that are actively transported across the intact tympanic membrane (TM) of rats with infected middle ears. To assess the possibility that this transport would also occur across the human TM, we first developed and ...
Alexander, Thomas, Bernhardt, Marlen, Harris, Jeffrey P, Husseman, Jacob, Kurabi, Arwa, Nguyen, Quyen, Noack, Volker, Pak, Kwang, Ryan, Allen F, Schaerer, Daniel   +9 more
core   +1 more source

Galectin-4-mediated transcytosis of transferrin receptor [PDF]

Journal of Cell Science, 2014
Some native epithelia, e.g. Retinal Pigment Epithelium (RPE) and Kidney Proximal Tubule (KPT) constitutively lack the basolateral sorting adaptor AP-1B; this results in many basolateral plasma membrane proteins repositioned to the apical domain, where they perform essential functions for their host organs.
Andres E, Perez Bay, Ryan, Schreiner, Ignacio, Benedicto, Enrique J, Rodriguez-Boulan   +3 more
openaire   +2 more sources

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, EarlyView.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source