Results 61 to 70 of about 14,180 (293)
The Journal of Cell Biology, 1999 Tight junctions (TJs) in endothelial cells are thought to determine vascular permeability. Recently, claudin-1 to -15 were identified as major components of TJ strands. Among these, claudin-5 (also called transmembrane protein deleted in velo-cardio-facial syndrome [TMVCF]) was expressed ubiquitously, even in organs lacking epithelial tissues ...
Kazumasa Morita +3 more
openaire +1 more source
Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design
Advanced Science, EarlyView.Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng +7 more
wiley +1 more source
Frontiers in Physiology, 2022 The proinflammatory cytokine tumor necrosis factor (TNF) has been described as one of the main mediators of intestinal inflammatory diseases, affecting the composition of tight junction (TJ) proteins and leading to a disruption of the epithelial barrier.
Linda Droessler +5 more
doaj +1 more source
Chemical tools for isolation of endogenous claudins from carcinoma cells
, 2018 Claudins are a family of tetraspan transmembrane proteins that regulate the barrier function and ion selective paracellular permeability of the tight junction.
Payal Barua (12311765)
core +1 more source
Advanced Science, EarlyView.Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang +11 more
wiley +1 more source
Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment
Communications BiologyClaudins are a 27-member family of ~25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial cells.
Satchal K. Erramilli +4 more
doaj +1 more source
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, EarlyView.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Claudins as diagnostic and prognostic markers in gynecological cancer [PDF]
, 2009 Claudins are the main protein components of tight junctions (TJs) which function as selective barriers by controlling paracellular diffusion, maintain cellular polarity and play a role in signal transduction.
Schaff, Zsuzsa +3 more
core
The renal segmental distribution of claudins changes with development
, 2002 The renal segmental distribution of claudins changes with development.BackgroundPermeability properties of mammalian nephron are tuned during postnatal maturation.
Reyes, Jose Luis +7 more
core +1 more source
Finding the junction between claudins and endometrial carcinoma [PDF]
, 2023 : Endometrial carcinoma (EC) defines a heterogeneous group of neoplastic diseases originating from the transformation of endometrial cells that constitute the internal lining of the uterus. To date several molecular targets have been analysed to describe
Bignotti, Eliana +4 more
core +1 more source