Results 71 to 80 of about 20,650 (306)

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Dexamethasone in glioblastoma multiforme therapy : mechanisms and controversies [PDF]

, 2019
Glioblastoma multiforme (GBM) is the most common and malignant of the glial tumors. The world-wide estimates of new cases and deaths annually are remarkable, making GBM a crucial public health issue.
Luigi Sforna, Maria Cristina D’Adamo, Mario Valentino, Marta Cenciarini, Mauro Pessia, Mauro Pessia, Paolo Rosa, Silvia Belia, Simona Ronchetti   +8 more
core   +2 more sources

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin

Toxins, 2023
Clostridium perfringens enterotoxin (CpE) is a β-pore forming toxin that disrupts gastrointestinal homeostasis in mammals by binding membrane protein receptors called claudins.
Chinemerem P. Ogbu, Srajan Kapoor, Alex J. Vecchio   +2 more
doaj   +1 more source

Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer [PDF]

, 2009
Background The absence of highly sensitive and specific serum biomarkers makes mass screening for ovarian cancer impossible. The claudin proteins are frequently overexpressed in ovarian cancers, but their potential as prognostic, diagnostic, or detection
Jianghong Li, Cheryl A Sherman-Baust, Miyun Tsai-Turton, Robert E Bristow, Richard B Roden, Patrice J Morin, A Jemal, TI Goonewardene, RC Bast Jr, D Badgwell, EV Hogdall, S Skates, I Jacobs, U Menon, SS Buys, LJ Havrilesky, S Tsukita, PJ Morin, CD Hough, LBA Rangel, AD Santin, K Hibbs, VA Heinzelmann-Schwarz, KH Lu, E Bignotti, Y Zhu, YL Choi, L Kleinberg, P Michl, R Agarwal, G Sobel, P Dhawan, N Oku, Y Usami, PD Leotlela, T Oshima, YH Huang, GE Konecny, M Lechpammer, C Thery, F Andre, DD Taylor, F Andre, J Mallegol, K Koga, M Furlong, C Thery, GM Yousef, I Hellstrom, DG Rosen, G Mor, DD Taylor, S Runz, A Lakkaraju   +53 more
core   +2 more sources

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Salinity Regulates Claudin mRNA and Protein Expression in the Teleost Gill [PDF]

, 2008
  Udgivelsesdato: 2008-Jan-9The teleost gill carries out NaCl uptake in fresh water (FW) and NaCl excretion in seawater (SW). This transformation with salinity requires close regulation of ion transporter capacity and epithelial permeability.
Baltzegar, David A, Borski, Russell J, Grubb, Brenda J, Ozden, Ozkan, Tipsmark, Christian K   +4 more
core   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment

Communications Biology
Claudins are a 27-member family of ~25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial cells.
Satchal K. Erramilli, Pawel K. Dominik, Chinemerem P. Ogbu, Anthony A. Kossiakoff, Alex J. Vecchio   +4 more
doaj   +1 more source

Mouse Models of Human Claudin-Associated Disorders: Benefits and Limitations [PDF]

, 2019
In higher organisms, epithelia separate compartments in order to guarantee their proper function. Such structures are able to seal but also to allow substances to pass.
Fernández-Rodríguez, Cármen, Martínez-Cruz, Luis Alfonso, Müller, Dominik, Seker, Murat   +3 more
core   +1 more source