Results 51 to 60 of about 20,650 (306)

Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2019
Claudin (CLDN) proteins, a tetra-transmembrane family containing over 20 members, have been identified as key structural and functional components of intercellular seals, tight junctions (TJs). CLDNs are involved in the barrier and fence functions of TJs. Loosening the TJ barrier is one strategy for increasing drug absorption and delivery to the brain.
Yosuke, Hashimoto, Yoshiaki, Okada, Keisuke, Shirakura, Keisuke, Tachibana, Makoto, Sawada, Kiyohito, Yagi, Takefumi, Doi, Masuo, Kondoh   +7 more
openaire   +2 more sources

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Optimal DL-Methionyl-DL-Methionine Supplementation Improved Intestinal Physical Barrier Function by Changing Antioxidant Capacity, Apoptosis and Tight Junction Proteins in the Intestine of Juvenile Grass Carp (Ctenopharyngodon idella)

Antioxidants, 2022
The present study was a part of a larger research project that aimed to investigate the effects of Met-Met supplementation on fish growth and intestinal health. This study mainly focused on the relationship between dietary Met-Met and intestinal physical
Pei Wu, Yuening Su, Lin Feng, Weidan Jiang, Shengyao Kuang, Ling Tang, Jun Jiang, Yang Liu, Xiaoqiu Zhou   +8 more
doaj   +1 more source

Structure and function of claudins

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008
Claudins are tetraspan transmembrane proteins of tight junctions. They determine the barrier properties of this type of cell-cell contact existing between the plasma membranes of two neighbouring cells, such as occurring in endothelia or epithelia. Claudins can completely tighten the paracellular cleft for solutes, and they can form paracellular ion ...
Krause, Gerd, Winkler, Lars, Mueller, Sebastian L., Haseloff, Reiner F., Piontek, Jörg, Blasig, Ingolf E.   +5 more
openaire   +2 more sources

Branchial Expression Patterns of Claudin Isoforms in Atlantic Salmon During Seawater Acclimation and Smoltification [PDF]

, 2008
  Udgivelsesdato: 2008-Mar-5In euryhaline teleosts, permeability changes in gill epithelia are essential during acclimation to changed salinity. This study examined expression patterns of branchial tight junction proteins called claudins, which are ...
Ebbesson, Lars Oe, Kiilerich, Pia, Madsen, Steffen S, Nilsen, Tom O, Stefansson, Sigurd O, Tipsmark, Christian K   +5 more
core   +1 more source

Claudin-16 and claudin-19 function in the thick ascending limb [PDF]

Current Opinion in Nephrology and Hypertension, 2010
Claudin-16 and claudin-19 play a major role in the regulation of magnesium reabsorption in the thick ascending limb (TAL). This review describes recent findings of the physiological function of claudin-16 and claudin-19 underlying normal transport function for magnesium reabsorption in the TAL.Mutations in the genes encoding the tight junction proteins
Jianghui, Hou, Daniel A, Goodenough
openaire   +2 more sources

Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction

Frontiers in Physiology, 2020
Claudin-5 determines the sealing properties of blood-brain barrier tight junctions and its function is impaired in neurodegenerative and neuroinflammatory disorders.
Nora Brunner, Laura Stein, Valeria Cornelius, Ria Knittel, Petra Fallier-Becker, Salah Amasheh   +5 more
doaj   +1 more source

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli. [PDF]

, 2016
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
McCole, Declan F, Shawki, Ali
core   +1 more source

miR-195-5p Regulates Tight Junctions Expression via Claudin-2 Downregulation in Ulcerative Colitis

Biomedicines, 2022
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation associated with an increased intestinal permeability. Several studies have shown that microRNAs (miRNAs) are involved in the IBD pathogenesis.
Viviana Scalavino, Emanuele Piccinno, Antonio Lacalamita, Angela Tafaro, Raffaele Armentano, Gianluigi Giannelli, Grazia Serino   +6 more
doaj   +1 more source

Claudin expression during early postnatal development of the murine cochlea [PDF]

, 2018
Citation: Kudo, T., Wangemann, P., & Marcus, D. C. (2018). Claudin expression during early postnatal development of the murine cochlea. BMC Physiology, 18(1), 1.
Kudo, Takayuki, Marcus, Daniel C., Wangemann, Philine   +2 more
core   +3 more sources