Results 1 to 10 of about 266,488 (115)

Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease

EBioMedicine, 2022
Summary: Background: Loss of intestinal epithelial barrier integrity is a critical component of Inflammatory Bowel Disease (IBD) pathogenesis. Co-expression regulation of ligand-receptor pairs in IBD mucosa has not been systematically studied. Targeting
Yang Cheng, Tyler R. Hall, Xiao Xu, Ivy Yung, Donald Souza, Jie Zheng, Felix Schiele, Matthias Hoffmann, M. Lamine Mbow, James P. Garnett, Jun Li   +10 more
doaj   +3 more sources

ATP-related purinergic signaling via P2Y12 contributes to airway epithelial barrier integrity [PDF]

BMC Molecular and Cell Biology
Background The airway epithelial barrier, which defends against external pathogens, is compromised in bronchial asthma. This study investigated the roles of adenosine triphosphate (ATP) and specific purinergic receptors in airway epithelial barrier ...
Kota Tsuya, Shuichiro Maruoka, Shinichi Okamoto, Sotaro Shikano, Mari Ujike, Shiho Yamada, Yusuke Kurosawa, Kenji Mizumura, Yutaka Kozu, Yasuhiro Gon   +9 more
doaj   +2 more sources

The involvement of Th17 inflammation and miR-363-3p in airway epithelial barrier dysfunction [PDF]

Respiratory Research
Background Impaired airway epithelial barrier function is a pathogenic driver in a subset of individuals with asthma. MicroRNAs, small RNAs that function as post-transcriptional regulators of gene expression, may be involved in the regulation of the ...
Cecilia Lässer, Elisabeth Ax, Julie Weidner, Sofia Winslow, Hannes Ingelhag, Jenny Calvén, Carina Malmhäll, Zala Jevnikar, Henric Olsson, Madeleine Rådinger   +9 more
doaj   +2 more sources

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier [PDF]

Advanced Science
Strict regulation of epithelial cells is crucial for maintaining intestinal barrier integrity and preventing intestinal diseases. While transcriptional regulation is well recognized as vital in this process, translational regulation is equally important.
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
doaj   +2 more sources

Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma

Chinese Medical Journal, 2022
. Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis, allergic asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyps.
Xiang Dong, Mei Ding, Jinjin Zhang, Ismail Ogülür, Yagiz Pat, Mübeccel Akdis, Yadong Gao, Cezmi A. Akdis, Peifang Wei   +8 more
doaj   +1 more source

Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge.

PLoS ONE, 2021
Airway epithelial barrier dysfunction is increasingly recognized as a key feature of asthma and other lung diseases. Respiratory viruses are responsible for a large fraction of asthma exacerbations, and are particularly potent at disrupting epithelial ...
Clara Rimmer, Savas Hetelekides, Sophia I Eliseeva, Steve N Georas, Janelle M Veazey   +4 more
doaj   +3 more sources

Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling

Microbiome, 2023
Background The intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins. Growing studies have linked the gut microbiota to the intestinal epithelial barrier function.
Jun Hu, Jianwei Chen, Xiaojian Xu, Qiliang Hou, Jing Ren, Xianghua Yan   +5 more
doaj   +1 more source

Macrophages and Epithelial Cells Mutually Interact through NLRP3 to Clear Infection and Enhance the Gastrointestinal Barrier

Immuno, 2021
Activation of the nod-like receptor protein 3 (NLRP3) leads to the release of the proinflammatory cytokine IL-1β, which then facilitates pathogen control by macrophages.
Michael Bording-Jorgensen, Heather Armstrong, Madison Wickenberg, Paul LaPointe, Eytan Wine   +4 more
doaj   +1 more source

Role of Autophagy Inducers and Inhibitors in Intestinal Barrier Injury Induced by Intestinal Ischemia–Reperfusion (I/R)

Journal of Immunology Research, 2022
Objectives. Intestinal epithelial barrier function is an important mechanical barrier to maintain intestinal homeostasis and resist the invasion of intestinal pathogens and microorganisms.
Yuejin Li, Peng Zhang, Jian Zhang, Weimin Bao, Jinyuan Li, Yan Wei, Jinchao Ni, Kunmei Gong   +7 more
doaj   +1 more source

The relation between age and airway epithelial barrier function

Respiratory Research, 2022
Background The prevalence of age-associated diseases, such as chronic obstructive pulmonary disease (COPD), is increasing as the average life expectancy increases around the world.
M. de Vries, K. O. Nwozor, K. Muizer, M. Wisman, W. Timens, M. van den Berge, A. Faiz, T.-L. Hackett, I. H. Heijink, C. A. Brandsma   +9 more
doaj   +1 more source