Results 21 to 30 of about 274,446 (288)

Rebeccamycin Attenuates TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Inhibiting Myosin Light Chain Kinase Production

Cellular Physiology and Biochemistry, 2017
Background/Aims: Although proinflammatory cytokine–induced disruption of intestinal epithelial barrier integrity is associated with intestinal inflammatory disease, effective treatment for barrier dysfunction is lacking.
Akihiro Watari, Yuta Sakamoto, Kota Hisaie, Kazuki Iwamoto, Miho Fueta, Kiyohito Yagi, Masuo Kondoh   +6 more
doaj   +2 more sources

MMP12 disrupts epithelial barrier integrity in oral lichen planus by degrading fibronectin

Scientific Reports
Oral lichen planus (OLP) is a chronic inflammatory disorder featured with T lymphocytes infiltration and epithelial basement membrane breakdown. Although matrix metalloproteinase-12 (MMP12) is reported to be involved in the pathogenesis of oral diseases ...
Zhouqiao Xie, Xiangyu Wang, Xiuyun Ren, Xuejun Ge   +3 more
doaj   +2 more sources

Adenosine in Intestinal Epithelial Barrier Function

Cells
At the intestinal front, several lines of defense are in place to resist infection and injury, the mucus layer, gut microbiome and strong epithelial junctions, to name a few. Their collaboration creates a resilient barrier. In intestinal disorders, such as inflammatory bowel disease (IBD), barrier function is compromised, which results in rampant ...
Mariya Stepanova, Carol M. Aherne
openaire   +4 more sources

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease [PDF]

Allergy, 2022
AbstractEnvironmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external (e.g., chemical pollutants or lifestyle factors), and general external (e.g., broader socioeconomic and psychological contexts) domains, all of which ...
Celebi Sozener, Zeynep, Ozdel Ozturk, Betul, Cerci, Pamir, Turk, Murat, Gorgulu Akin, Begum, Akdis, Mubeccel, Altiner, Seda, Ozbey, Umus, Ogulur, Ismail, Mitamura, Yasutaka, Yilmaz, Insu, Nadeau, Kari, Ozdemir, Cevdet, Mungan, Dilsad, Akdis, Cezmi A   +14 more
openaire   +4 more sources

Dysregulation of the epithelial barrier by environmental and other exogenous factors [PDF]

, 2021
The “epithelial barrier hypothesis” proposes that the exposure to various epithelial barrier–damaging agents linked to industrialization and urbanization underlies the increase in allergic diseases.
Akdis, Mubeccel, Ismail Ogulur, Brüggen, Marie‐Charlotte, Brüggen, Charlotte, Ardicli, Ozge, Akdis, Cezmi A., Ogulur, Ismail, Marie‐Charlotte Brüggen, Rinaldi, Arturo O., Lacin Cevhertas, Cevhertas, Lacin, Yagiz Pat, Ozge Ardicli, Cezmi A. Akdis, Pat, Yağız, Traidl-Hoffmann, Claudia, Arturo O. Rinaldi, Claudia Traidl‐Hoffmann, Mitamura, Yasutaka, Traidl‐Hoffmann, Claudia, Pat, Yagiz, Ardıçlı, Özge, Mubeccel Akdis, Brueggen, Marie-Charlotte, Yasutaka Mitamura   +24 more
core   +4 more sources

Epithelial barriers in allergy and asthma [PDF]

Journal of Allergy and Clinical Immunology, 2020
The respiratory epithelium provides a physical, functional, and immunologic barrier to protect the host from the potential harming effects of inhaled environmental particles and to guarantee maintenance of a healthy state of the host. When compromised, activation of immune/inflammatory responses against exogenous allergens, microbial substances, and ...
Hellings, Peter W., Steelant, Brecht
openaire   +3 more sources

Allergy as an epithelial barrier disease [PDF]

Clinical and Translational Allergy, 2011
AbstractThe objective of this review is to focus on putative modified epithelial functions related to allergy. The dysregulation of the epithelial barrier might result in the allergen uptake, which could be the primary defect in the pathogenesis of allergic reaction.
Mattila Pirkko, Joenväärä Sakari, Renkonen Jutta, Toppila-Salmi Sanna, Renkonen Risto   +4 more
openaire   +3 more sources

Globoside and the mucosal pH mediate parvovirus B19 entry through the epithelial barrier. [PDF]

, 2023
Parvovirus B19 (B19V) is transmitted primarily via the respiratory route, however, the mechanism involved remains unknown. B19V targets a restricted receptor expressed in erythroid progenitor cells in the bone marrow.
Colakovic, Minela, Dijkman, Ronald, Ros, Carlos, Bieri, Jan, Suter, Corinne, Gultom, Mitra   +5 more
core   +1 more source

Investigating the epithelial barrier and immune signatures in the pathogenesis of equine insect bite hypersensitivity. [PDF]

, 2020
Insect bite hypersensitivity (IBH) is a Th-2, IgE-mediated dermatitis of horses caused by bites of insects of the genus Culicoides that has common features with human atopic dermatitis.
Eliane Isabelle Marti, Iva Cvitas, Simone Oberhänsli, Eliane Müller, Dettwiler, Martina, Bruggmann, Rémy, Tosso Leeb, Marti, Eliane Isabelle, Martina Dettwiler, Oberhänsli, Simone, Müller, Eliane Jasmine, Cvitas, Iva, Leeb, Tosso, Remy Bruggman   +13 more
core   +1 more source

Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis

World Allergy Organization Journal, 2021
Tight junction defects (TJ) have been associated with a defective epithelial barrier function in allergic rhinitis (AR). Intranasal corticosteroids are potent drugs frequently used to treat AR and are shown to restore epithelial integrity by acting on ...
Maria Doulaptsi, Tine Wils, Peter W. Hellings, Katleen Martens, Ricard Farré, Maria Vicario, Wytske Fokkens, Emmanuel Prokopakis, Brecht Steelant   +8 more
doaj   +1 more source