Results 11 to 20 of about 274,446 (288)

Epithelial barrier dysfunction in bronchial asthma

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2022
The pathogenesis of bronchial asthma is based on chronic inflammation as a response to etiological factors. It causes bron-chial hyperreactivity, remodeling of the respiratory tract and hypersecretion of mucus.
R. N. Khramova, T. I. Eliseeva, T. E. Potemina   +2 more
doaj   +3 more sources

Epithelial barrier dysfunction in ocular allergy [PDF]

Allergy, 2021
AbstractThe epithelial barrier is the first line of defense that forms a protective barrier against pathogens, pollutants, and allergens. Epithelial barrier dysfunction has been recently implicated in the development of allergic diseases such as asthma, atopic dermatitis, food allergy, and rhinitis.
Singh, Neera, Diebold Luque, María Yolanda, Sahu, Srikant K, Leonardi, Andrea   +3 more
core   +8 more sources

Plasma polymerized bio-interface directs fibronectin adsorption and functionalization to enhance “epithelial barrier structure” formation via FN-ITG β1-FAK-mTOR signaling cascade

Biomaterials Research, 2022
Background Transepithelial medical devices are increasing utilized in clinical practices. However, the damage of continuous natural epithelial barrier has become a major risk factor for the failure of epithelium-penetrating implants. How to increase the “
Shoucheng Chen, Zhuwei Huang, Rahul Madathiparambil Visalakshan, Haiwen Liu, Akash Bachhuka, You Wu, Panthihage Ruvini L. Dabare, Pu Luo, Runheng Liu, Zhuohong Gong, Yin Xiao, Krasimir Vasilev, Zhuofan Chen, Zetao Chen   +13 more
doaj   +2 more sources

Intestinal epithelial barrier integrity investigated by label-free techniques in ulcerative colitis patients [PDF]

Scientific Reports, 2023
The intestinal epithelial barrier, among other compartments such as the mucosal immune system, contributes to the maintenance of intestinal homeostasis.
Elsie Quansah, Elena Gardey, Anuradha Ramoji, Tobias Meyer-Zedler, Bianca Goehrig, Astrid Heutelbeck, Stephanie Hoeppener, Michael Schmitt, Maximillian Waldner, Andreas Stallmach, Jürgen Popp   +10 more
doaj   +4 more sources

Recent advances in the epithelial barrier theory [PDF]

International Immunology
Abstract The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting the epithelial barrier. Global pollution and environmental toxic agent exposure have worsened over six decades because of uncontrolled growth, modernization, and ...
Yagiz Pat, Duygu Yazici, Paolo D’Avino, Manru Li, Sena Ardicli, Ozge Ardicli, Yasutaka Mitamura, Mübeccel Akdis, Raja Dhir, Kari Nadeau, Ioana Agache, Ismail Ogulur, Cezmi A Akdis   +12 more
core   +5 more sources

Celiac Disease: Role of the Epithelial Barrier [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
In celiac disease (CD) a T-cell–mediated response to gluten is mounted in genetically predisposed individuals, resulting in a malabsorptive enteropathy histologically highlighted by villous atrophy and crypt hyperplasia. Recent data point to the epithelial layer as an under-rated hot spot in celiac pathophysiology to date.
Schumann, Michael, Siegmund, Britta, Schulzke, Jörg D., Fromm, Michael   +3 more
openaire   +4 more sources

Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates airway epithelial barrier integrity

Allergology International, 2015
Background: Inhaled corticosteroids enhance airway epithelial barrier integrity. However, the mechanism by which they accomplish this is unclear. Therefore, we investigated steroid-inducible genes and signaling pathways that were involved in enhancing ...
Yoshitaka Shintani, Shuichiro Maruoka, Yasuhiro Gon, Daisuke Koyama, Akiko Yoshida, Yutaka Kozu, Kazumichi Kuroda, Ikuko Takeshita, Eriko Tsuboi, Kaori Soda, Shu Hashimoto   +10 more
doaj   +2 more sources

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coliSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
Ali Shawki, Declan F. McCole
doaj   +2 more sources

The epithelial barrier: a Janus-faced regulator in allergic airway diseases from defense to inflammation [PDF]

Frontiers in Allergy
BackgroundThe epithelial barrier serves as the body's first line of defense between the host immune system and the external environment. Evidence confirms that epithelial barrier damage is an initial event in the pathogenesis of allergic respiratory ...
Youwei Bao, Qi Chen, Binbin Shi, Xinhua Zhu   +3 more
doaj   +2 more sources

Intestinal epithelial barrier functions in ageing [PDF]

Ageing Research Reviews, 2019
The intestinal epithelial barrier protects the mucosa of the gastrointestinal (GI)-tract and plays a key role in maintaining the host homeostasis. It encompasses several elements that include the intestinal epithelium and biochemical and immunological products, such as the mucus layer, antimicrobial peptides (AMPs) and secretory immunologlobulin A ...
Jacopo J V, Branca, Massimo, Gulisano, Claudio, Nicoletti   +2 more
openaire   +3 more sources