Results 41 to 50 of about 274,446 (288)

The Esophageal Epithelial Barrier in Health and Disease [PDF]

Clinical Gastroenterology and Hepatology, 2018
Dysfunction in the esophageal epithelial barrier function is a major source for morbidity. To better understand the pathophysiologic pathways of the diseases associated with barrier dysfunction, including gastroesophageal reflux disease, eosinophilic esophagitis, Barrett's esophagus, and obesity, it is important to understand the esophageal epithelial ...
Christopher H. Blevins, Prasad G. Iyer, Marcelo F. Vela, David A. Katzka   +3 more
openaire   +2 more sources

Epithelial Barrier Dysfunction in Chronic Respiratory Diseases.

, 2021
Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive module that ensures first-line defense against external toxics, irritants, antigens, and pathogens.
Pilette, Charles, Carlier, François, de Fays, Charlotte   +2 more
core   +1 more source

Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin

Particle and Fibre Toxicology, 2020
Background While exposure to diesel exhaust particles has been linked to aberrant immune responses in allergic diseases such as asthma, little attention has been paid to their effects on the airway epithelial barrier.
Timothy Smyth, Janelle Veazey, Sophia Eliseeva, David Chalupa, Alison Elder, Steve N. Georas   +5 more
doaj   +1 more source

Azithromycin ameliorated cigarette smoke-induced airway epithelial barrier dysfunction by activating Nrf2/GCL/GSH signaling pathway

Respiratory Research, 2023
Background Airway epithelium is the first barrier against environmental insults, and epithelial barrier dysfunction caused by cigarette smoke (CS) is particularly relevant to chronic obstructive pulmonary disease (COPD) progression.
Yun Song, Wenhuan Fu, Youzhi Zhang, Doudou Huang, Jian Wu, Shuangmei Tong, Mingkang Zhong, Huifang Cao, Bin Wang   +8 more
doaj   +1 more source

Construction of the tracheal epithelial barrier model.

, 2022
(A) Transepithelial electrical resistance (TEER) value of the tracheal epithelial barrier model. (B) FD-4 flux of STECs grown on Transwell inserts. The unpaired t test was used to test the significance of the data. ****, P (PDF)
Huixing Lin (4033031), Qing Wang (27728), Ting Zhu (460268), Kai Niu (818117), Hongjie Fan (167764), Zhe Ma (167751), Yu Meng (152553), Chengping Lu (167772), Weiyi Li (285926)   +8 more
core   +1 more source

Epithelial barrier repair and prevention of allergy [PDF]

Journal of Clinical Investigation, 2019
Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial ...
Elena Goleva, Evgeny Berdyshev, Donald Y.M. Leung   +2 more
openaire   +2 more sources

Mechanisms of pulmonary fibrosis and lung cancer induced by chronic PM2.5 exposure: Focus on the airway epithelial barrier and epithelial-mesenchymal transition

Ecotoxicology and Environmental Safety
This study aims to provide new insights into PM2.5-induced lung diseases through a focus on the pulmonary epithelial barrier and epithelial-mesenchymal transition (EMT).
Yuyu Shi, Qi Shao, Zilin Ren, Guojiao Shang, Jinhua Han, Jialin Cheng, Yuxiao Zheng, Fafeng Cheng, Changxiang Li, Qingguo Wang, Xueqian Wang   +10 more
doaj   +1 more source

N-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines

, 2008
Defects in tight junction barrier have been considered as an important etiologic factor of Crohn's disease. n-3 polyunsaturated fatty acids (PUFAs) exert beneficial effects on inflammatory bowel disorders. However, the mechanisms remain unknown. We found
Zhao, Sumin, Zhang, Qiang, Li, Qiurong, Wang, Meng, Li, Jieshou, 黎介寿, Xu, Guowang   +6 more
core   +1 more source

Glaesserella parasuis serotype 5 breaches the porcine respiratory epithelial barrier by inducing autophagy and blocking the cell membrane Claudin-1 replenishment.

PLoS Pathogens, 2022
Glaesserella parasuis (G. parasuis), the primary pathogen of Glässer's disease, colonizes the upper respiratory tract and can break through the epithelial barrier of the respiratory tract, leading to lung infection. However, the underlying mechanisms for
Mingxing Liu, Qing Wang, Wenda Wu, Min Chen, Pengyun Zhang, Mengru Guo, Huixing Lin, Zhe Ma, Hong Zhou, Hongjie Fan   +9 more
doaj   +1 more source

Choreographing Immunity in the Skin Epithelial Barrier [PDF]

Immunity, 2019
The skin interfaces with the external environment and is home to a myriad of immune cells that patrol the barrier to ward off harmful agents and aid in tissue repair. The formation of the cutaneous immune arsenal begins before birth and evolves throughout our lifetime, incorporating exogenous cues from microbes and inflammatory encounters, to achieve ...
Tetsuro, Kobayashi, Shruti, Naik, Keisuke, Nagao   +2 more
openaire   +2 more sources