Results 1 to 10 of about 201,161 (293)

Adenosine in Intestinal Epithelial Barrier Function [PDF]

Cells
At the intestinal front, several lines of defense are in place to resist infection and injury, the mucus layer, gut microbiome and strong epithelial junctions, to name a few. Their collaboration creates a resilient barrier.
Mariya Stepanova, Carol M. Aherne
doaj   +4 more sources

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coliSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
Ali Shawki, Declan F. McCole
doaj   +3 more sources

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier [PDF]

Advanced Science
Strict regulation of epithelial cells is crucial for maintaining intestinal barrier integrity and preventing intestinal diseases. While transcriptional regulation is well recognized as vital in this process, translational regulation is equally important.
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
doaj   +2 more sources

Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease

EBioMedicine, 2022
Summary: Background: Loss of intestinal epithelial barrier integrity is a critical component of Inflammatory Bowel Disease (IBD) pathogenesis. Co-expression regulation of ligand-receptor pairs in IBD mucosa has not been systematically studied. Targeting
Yang Cheng, Tyler R. Hall, Xiao Xu, Ivy Yung, Donald Souza, Jie Zheng, Felix Schiele, Matthias Hoffmann, M. Lamine Mbow, James P. Garnett, Jun Li   +10 more
doaj   +3 more sources

Daidzein Protects Caco-2 Cells against Lipopolysaccharide-Induced Intestinal Epithelial Barrier Injury by Suppressing PI3K/AKT and P38 Pathways

Molecules, 2022
The intestinal epithelium provides an important barrier against bacterial endotoxin translocation, which can regulate the absorption of water and ions. The disruption of epithelial barrier function can result in water transport and tight junction damage,
Baoping Zhang, Xiaohan Wei, Mengze Ding, Zhenye Luo, Xiaomei Tan, Zezhong Zheng   +5 more
doaj   +3 more sources

Baicalin mitigates hyperglycemia-linked intestinal epithelial barrier impairment in part by inhibiting the formation of neutrophil extracellular traps [PDF]

Frontiers in Immunology
BackgroundUnder hyperglycemic conditions, impaired intestinal barrier integrity leads to heightened level of inflammation, playing important roles in driving diabetic complications.
Yiqing Cai, Qinbo Yang, Qinbo Yang, Xinmiao Tang, Peiwei Wang, Peiwei Wang, Jingang Cui, Jingang Cui, Xiaoye Du, Xiaoye Du, Teng Zhang, Teng Zhang, Yu Chen, Yu Chen, Yu Chen   +14 more
doaj   +2 more sources

Role of Autophagy Inducers and Inhibitors in Intestinal Barrier Injury Induced by Intestinal Ischemia–Reperfusion (I/R)

Journal of Immunology Research, 2022
Objectives. Intestinal epithelial barrier function is an important mechanical barrier to maintain intestinal homeostasis and resist the invasion of intestinal pathogens and microorganisms.
Yuejin Li, Peng Zhang, Jian Zhang, Weimin Bao, Jinyuan Li, Yan Wei, Jinchao Ni, Kunmei Gong   +7 more
doaj   +1 more source

Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling

Microbiome, 2023
Background The intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins. Growing studies have linked the gut microbiota to the intestinal epithelial barrier function.
Jun Hu, Jianwei Chen, Xiaojian Xu, Qiliang Hou, Jing Ren, Xianghua Yan   +5 more
doaj   +1 more source

Human organoids are superior to cell culture models for intestinal barrier research

Frontiers in Cell and Developmental Biology, 2023
Loss of intestinal epithelial barrier function is a hallmark in digestive tract inflammation. The detailed mechanisms remain unclear due to the lack of suitable cell-based models in barrier research.
Catherine Kollmann, Hannah Buerkert, Michael Meir, Konstantin Richter, Kai Kretzschmar, Sven Flemming, Matthias Kelm, Christoph-Thomas Germer, Christoph Otto, Natalie Burkard, Nicolas Schlegel   +10 more
doaj   +1 more source

Cytokine tuning of intestinal epithelial function [PDF]

, 2018
The intestine serves as both our largest single barrier to the external environment and the host of more immune cells than any other location in our bodies.
Andrews, Caroline, Durum, Scott K., McLean, Mairi H.   +2 more
core   +7 more sources