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Organoid and Enteroid Modeling of Salmonella Infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Salmonella are Gram-negative rod-shaped facultative anaerobic bacteria that are comprised of over 2,000 serovars. They cause gastroenteritis (salmonellosis) with headache, abdominal pain and diarrhea clinical symptoms. Salmonellosis brings a heavy burden
Yuebang Yin, Daoguo Zhou, Daoguo Zhou
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Infant and adult human intestinal enteroids are morphologically and functionally distinct
MBio, 2023 Human intestinal enteroids (HIEs) are gaining recognition as physiologically relevant models of the intestinal epithelium. While HIEs from adults are used extensively in biomedical research, few studies have used HIEs from infants.
Grace Adeniyi-Ipadeola +2 more
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Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid MonolayersSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2018 Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl- and HCO3- secretion to total cyclic adenosine monophosphate (cAMP ...
Jianyi Yin +6 more
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Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro
Frontiers in Microbiology, 2020 Porcine deltacoronavirus (PDCoV) is a novel emerging enteric coronavirus found in pigs. Intestinal enteroids, which partially recreate the structure and function of intestinal villi-crypts, have many physiological similarities to the intestinal tissues ...
Ying Shan, Jidong Xu, Min Yue
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Molecular Metabolism, 2021 Objective: The mechanisms behind the efficacy of bariatric surgery (BS) for treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel, remain poorly understood.
Nesrin M Hasan +2 more
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Apical-out bovine intestinal organoids as an infection model for Cryptosporidium parvum [PDF]
Current Research in Parasitology and Vector-Borne DiseasesCryptosporidium parvum is a major pathogen responsible for neonatal calf diarrhoea, but research has been hampered due to the lack of in vitro models that can complete the life cycle.
Mathilde Svensen Varegg +4 more
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Hypoxia Affects Stem Cell Fate in Patient-Derived Ileum Enteroids in a HIF-1α-Dependent Manner [PDF]
CellsThe intestinal epithelium maintains tissue homeostasis through a dynamic balance of stem cell proliferation and differentiation. This process is spatially regulated along the crypt–villus axis, with intestinal stem cells in the crypt regions ...
Zina M. Uckeley +13 more
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Frontiers in Microbiology, 2023 Salmonella enterica serovar Typhimurium (STm) is a major foodborne pathogen and poultry are a key reservoir of human infections. To understand the host responses to early stages of Salmonella infection in poultry, we infected 2D and 3D enteroids, the ...
Kate Sutton +7 more
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TNFα Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn’s DiseaseSummary
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Tumor necrosis factor alpha (TNFα) is considered a major tissue damage-promoting effector in Crohn’s disease (CD) pathogenesis. Patient-derived intestinal organoid (enteroid) recapitulates the disease-specific characteristics of ...
Chansu Lee +6 more
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Porcine small intestinal organoids as a model to explore ETEC–host interactions in the gut
Veterinary Research, 2021 Small intestinal organoids, or enteroids, represent a valuable model to study host–pathogen interactions at the intestinal epithelial surface. Much research has been done on murine and human enteroids, however only a handful studies evaluated the ...
Bjarne Vermeire +4 more
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