Results 1 to 10 of about 1,632 (88)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 23, 23 April 2026.We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang +9 more
wiley +1 more source
Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery
Advanced Science, Volume 13, Issue 20, 9 April 2026.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 9, 6 March 2026.Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez +8 more
wiley +1 more source
Advanced Biology, Volume 10, Issue 2, February 2026.This is the first study to demonstrate that the e‐transmembrane gut model provides more accurate physiological predictions than conventional cell culture inserts when tested by the dietary compound butyrate. The bioelectronic e‐transmembrane platform integrates technological and biological optimizations, enabling the hosting of a complex human gut in ...
Verena Stoeger +12 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 8, 23 February 2026.Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns +10 more
wiley +1 more source
Exploring microorganism–host interactions: Emerging organoid models and analytical approaches
mLife, Volume 5, Issue 1, Page 17-34, February 2026.Abstract Microorganisms play a vital role in human health through their interactions with the body. Studies of host–microbe mechanisms and interactions are crucial for advancing health management. Recently, the organoid‐based models have provided new platforms in this field.
Yue Shi +6 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 2, February 2026.ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley +1 more source
Advanced Materials Technologies, Volume 11, Issue 1, 8 January 2026.The modular, versatile, and standardized cartridge‐based culture module allows to replicate gut and vascular barriers. Its conventional handling requirements facilitate adoption by non‐technical users, while the design allows safe manipulation and retrieval of samples for permeability assays and endpoint analysis.
Lorenzo Pietro Coppadoro +6 more
wiley +1 more source
Decoding Host–Pathogen Interactions Through Caenorhabditis elegans: A Narrative Case Study
Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.Infectious diseases continue to pose a significant challenge to global health, particularly with the emergence of multidrug‐resistant pathogens. Understanding host–pathogen interactions (HPIs) is fundamental to uncovering mechanisms of infection, immunity, and adaptation.
Balasubramanian Chellammal Muthubharathi +2 more
wiley +1 more source