Results 11 to 20 of about 2,489 (115)

Bovine Enteroids as an In Vitro Model for Infection with Bovine Coronavirus

Viruses, 2023
Bovine coronavirus (BCoV) is one of the major viral pathogens of cattle, responsible for economic losses and causing a substantial impact on animal welfare.
Ruchika Shakya, Alejandro Jiménez-Meléndez, Lucy J. Robertson, Mette Myrmel   +3 more
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Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel Disease-specific Transcriptomic Signatures

Gastro Hep Advances, 2023
Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier.
Tatiana A. Karakasheva, Yusen Zhou, Hongbo M. Xie, Gloria E. Soto, Tiana D. Johnson, Madison A. Stoltz, Daana M. Roach, Noor Nema, Chizoba N. Umeweni, Kaitlyn Naughton, Lauren Dolinsky, James A. Pippin, Andrew D. Wells, Struan F.A. Grant, Louis Ghanem, Natalie Terry, Amanda B. Muir, Kathryn E. Hamilton   +17 more
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Infection of porcine enteroids and 2D differentiated intestinal epithelial cells with rotavirus A to study cell tropism and polarized immune response

Emerging Microbes and Infections, 2023
Intestinal epithelial cell interactions with enteric pathogens have been incompletely elucidated owing to the lack of model systems that recapitulate the cellular diversity, architecture and functionality of the intestine.
Miaomiao Yan, Ang Su, Suvarin Pavasutthipaisit, Rebecca Spriewald, Guntram A. Graßl, Andreas Beineke, Doris Hoeltig, Georg Herrler, Paul Becher   +8 more
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Potential capacities of different intestinal epithelial cell lines to form enteroids in 3D culture system: comparison and application

Di-san junyi daxue xuebao, 2020
Objective To compare the potentiality and characteristics of different intestinal epithelial cell (IEC) lines to grow into enteroids when cultured in 3D system in order to provide experimental basis for the cultivation of enteroids by IECs. Methods Three
OU Jing, XU Zhenni, LIU Dengqun
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Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease

The Journal of Clinical Investigation, 2023
Microvillus inclusion disease (MVID), caused by loss-of-function mutations in the motor protein myosin Vb (MYO5B), is a severe infantile disease characterized by diarrhea, malabsorption, and acid/base instability, requiring intensive parenteral support ...
Meri Kalashyan, Krishnan Raghunathan, Haley Oller, Marie-Theres Bayer, Lissette Jimenez, Joseph T. Roland, Elena Kolobova, Susan J. Hagen, Jeffrey D. Goldsmith, Mitchell D. Shub, James R. Goldenring, Izumi Kaji, Jay R. Thiagarajah   +12 more
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Evaluation of mouse enteroids as a model for Lawsonia intracellularis infection

Veterinary Research, 2019
Lawsonia intracellularis, an obligate intracellular bacterium, is an important enteric pathogen in pig herds and horse farms worldwide. The hallmark feature of L. intracellularis infection is the proliferation of epithelial cells in intestinal crypts.
Talita Pilar Resende, Ramya Lekha Medida, Yue Guo, Fabio A. Vannucci, Milena Saqui-Salces, Connie Gebhart   +5 more
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Novel chicken two-dimensional intestinal model comprising all key epithelial cell types and a mesenchymal sub-layer

Veterinary Research, 2021
The intestinal epithelium plays a variety of roles including providing an effective physical barrier and innate immune protection against infection. Two-dimensional models of the intestinal epithelium, 2D enteroids, are a valuable resource to investigate
Brigid Orr, Kate Sutton, Sonja Christian, Tessa Nash, Helle Niemann, Lone Lind Hansen, Mike J. McGrew, Stina Rikke Jensen, Lonneke Vervelde   +8 more
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Establishment of bovine 3D enteroid-derived 2D monolayers

Veterinary Research, 2022
Three-dimensional (3D) intestinal enteroids are powerful in vitro models for studying intestinal biology. However, due to their closed structure direct access to the apical surface is impeded, limiting high-throughput applications of exogenous compounds ...
Kate M. Sutton, Brigid Orr, Jayne Hope, Stina R. Jensen, Lonneke Vervelde   +4 more
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EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids

JCI Insight, 2023
Epithelial organoids derived from intestinal tissue, called enteroids, recapitulate many aspects of the organ in vitro and can be used for biological discovery, personalized medicine, and drug development.
Charlie J. Childs, Emily M. Holloway, Caden W. Sweet, Yu-Hwai Tsai, Angeline Wu, Abigail Vallie, Madeline K. Eiken, Meghan M. Capeling, Rachel K. Zwick, Brisa Palikuqi, Coralie Trentesaux, Joshua H. Wu, Oscar Pellón-Cardenas, Charles J. Zhang, Ian Glass, Claudia Loebel, Qianhui Yu, J. Gray Camp, Jonathan Z. Sexton, Ophir D. Klein, Michael P. Verzi, Jason R. Spence   +21 more
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Experimental Modeling of Necrotizing Enterocolitis in Human Infant Intestinal Enteroids

Journal of Investigative Surgery, 2022
Background: Experimental model systems are of paramount importance in advancing our understanding of human disease. Methods There are several limitations when using a single cell culture to recapitulate the findings in a complex organism and results ...
Christie Buonpane, Guillermo Ares, Carrie Yuan, Camille Schlegel, Heather Liebe, Catherine J. Hunter   +5 more
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