Results 31 to 40 of about 4,495 (215)
Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients With Intestinal Failure. [PDF]
, 2016 : Intestinal failure is a rare life-threatening condition that results in the inability to maintain normal growth and hydration status by enteral nutrition alone.
Dunn, James CY +3 more
core +1 more source
Intestinal organoid/enteroid-based models for Cryptosporidium
Current Opinion in Microbiology, 2020 Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients in resource-poor settings, and of waterborne outbreaks of disease in developed countries. However, there is no consistently effective treatment for vulnerable populations.
Bhalchandra, Seema +2 more
openaire +2 more sources
The Journal of Clinical Investigation, 2023 Microvillus inclusion disease (MVID), caused by loss-of-function mutations in the motor protein myosin Vb (MYO5B), is a severe infantile disease characterized by diarrhea, malabsorption, and acid/base instability, requiring intensive parenteral support ...
Meri Kalashyan +12 more
doaj +1 more source
Veterinary Research, 2021 The intestinal epithelium plays a variety of roles including providing an effective physical barrier and innate immune protection against infection. Two-dimensional models of the intestinal epithelium, 2D enteroids, are a valuable resource to investigate
Brigid Orr +8 more
doaj +1 more source
Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids. [PDF]
, 2016 Background & aimsIntestinal microfold (M) cells are specialized epithelial cells that act as gatekeepers of luminal antigens in the intestinal tract.
Dunn, James CY +11 more
core +4 more sources
Porcine colonoids and enteroids keep the memory of their origin during regeneration [PDF]
American Journal of Physiology-Cell Physiology, 2021 The development of alternative in vitro culture methods has increased in the last decade as three-dimensional organoids of various tissues, including those of the small and large intestines. Due to their multicellular composition, organoids offer advantages over traditionally used immortalized or primary cell lines. However, organoids must be accurate
Alicia M. Barnett +5 more
openaire +2 more sources
Thymosin β4 dynamics during chicken enteroid development [PDF]
Molecular and Cellular Biochemistry, 2020 AbstractThe sheared avian intestinal villus-crypts exhibit high tendency to self-repair and develop enteroids in culture. Presuming that this transition process involves differential biomolecular changes, we employed matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF–MS) to find whether there were differences in the
Mohan Acharya +6 more
openaire +3 more sources
EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids
JCI Insight, 2023 Epithelial organoids derived from intestinal tissue, called enteroids, recapitulate many aspects of the organ in vitro and can be used for biological discovery, personalized medicine, and drug development.
Charlie J. Childs +21 more
doaj +1 more source
Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. [PDF]
, 2015 Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell ...
Cramer, Julie M +14 more
core +2 more sources
Experimental Modeling of Necrotizing Enterocolitis in Human Infant Intestinal Enteroids
Journal of Investigative Surgery, 2022 Background: Experimental model systems are of paramount importance in advancing our understanding of human disease. Methods There are several limitations when using a single cell culture to recapitulate the findings in a complex organism and results ...
Christie Buonpane +5 more
doaj +1 more source