Results 51 to 60 of about 3,117 (204)
Antioxidants, 2023 Necrotizing enterocolitis (NEC) is a neonatal intestinal disease associated with oxidative stress. The targets of peroxidation and the role of the innate intestinal epithelial antioxidant defense system are ill-defined.
Alena Golubkova +9 more
doaj +1 more source
Human organoids are superior to cell culture models for intestinal barrier research
Frontiers in Cell and Developmental Biology, 2023 Loss of intestinal epithelial barrier function is a hallmark in digestive tract inflammation. The detailed mechanisms remain unclear due to the lack of suitable cell-based models in barrier research.
Catherine Kollmann +10 more
doaj +1 more source
Biology Open, 2017 Recent years have seen significant developments in the ability to continuously propagate organoids derived from intestinal crypts. These advancements have been applied to mouse and human samples providing models for gastrointestinal tissue development ...
Robin H. Powell, Michael S. Behnke
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
Differential response of enteroids and colonoids to Poly I:C stimulation.
, 2015 Fold change in gene expression of enteroids stimulated with Poly I:C and colonoids stimulated with Poly I:C were compared for differences in either magnitude of response or changes in the direction of response.
Julie M. Davies (412514) +4 more
core +1 more source
Advanced Science, Volume 13, Issue 23, 23 April 2026.We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang +9 more
wiley +1 more source
Human Intestinal Organoids: Promise and Challenge
Frontiers in Cell and Developmental Biology, 2022 The study of human intestinal biology in healthy and diseased conditions has always been challenging. Primary obstacles have included limited tissue accessibility, inadequate in vitro maintenance and ethical constrains.
Jasin Taelman +5 more
doaj +1 more source
Human enteroids: preclinical models of non-inflammatory diarrhea [PDF]
Stem Cell Research & Therapy, 2013 Researchers need an available and easy-to-use model of the human intestine to better understand human intestinal physiology and pathophysiology of diseases, and to offer an enhanced platform for developing drug therapy. Our work employs human enteroids derived from each of the major intestinal sections to advance understanding of several diarrheal ...
Kovbasnjuk, Olga +11 more
openaire +2 more sources
Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery
Advanced Science, Volume 13, Issue 20, 9 April 2026.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
iScience, 2023 Summary: Stem cells are a keystone of intestinal homeostasis, but their function could be shifted during energy imbalance or by crosstalk with microbial metabolites in the stem cell niche.
Mona Farhadipour +10 more
doaj +1 more source