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Effects of hormones on intestinal stem cells
Stem Cell Research & Therapy, 2023 The maintenance of intestinal renewal and repair mainly depends on intestinal stem cells (ISCs), which can also contribute to the growth of intestinal tumours.
Li Liu +6 more
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The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells [PDF]
CellsThe intestines are in a constant state of motion and self-renewal. The mechanical breakdown of food facilitates intestinal movement and aids digestion.
Jing-Jing Tu +3 more
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Digestive Diseases, 2013 The intestine has become a prime model system to study stem cell biology. Intestinal stem cells can be identified based on the expression of a unique marker gene, namely Lgr5. A transgenic mouse model expressing green fluorescent protein in intestinal stem cells has allowed their visualization, isolation, molecular characterization and use in ...
Bojic Sanja +3 more
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Stem cells: the intestinal stem cell as a paradigm [PDF]
Carcinogenesis, 2000 Stem cell research provides a foundation for therapeutic advancement in oncology, clinical genetics and a diverse array of degenerative disorders. For example, the elucidation of pathways governing proliferative regulation and differentiation within cellular systems will result in medical strategies aimed at the root cause of cancer.
S P, Bach, A G, Renehan, C S, Potten
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The intestinal stem cell [PDF]
Genes & Development, 2008 The epithelium of the adult mammalian intestine is in a constant dialog with its underlying mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation, and, ultimately, cell death. The epithelium is shaped into spatially distinct compartments that are dedicated to each of these events.
Barker, N. +2 more
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Journal of Cellular and Molecular Medicine, 2005 The intestinal tract has a rapid epithelial cell turnover, which continues throughout life. The process is regulated and maintained by a population of stem cells, which give rise to all the intestinal epithelial cell lineages. Studies in both the mouse and the human show that these cells are capable of forming clonal crypt populations.
Leedham, S +3 more
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Stem cells in the context of colon carcinogenesis (a literature review)
Zaporožskij Medicinskij Žurnal, 2023 Aim. To analyze the latest literature data on stem cells in general, intestinal stem cells in particular, as well as cancer stem cells in the context of colon carcinogenesis.
M. A. Shyshkin
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Intestinal stem cells and stem cell-based therapy for intestinal diseases [PDF]
Cytotechnology, 2014 Currently, many gastrointestinal diseases are a major reason for the increased mortality rate of children and adults every year. Additionally, these patients may cope with the high cost of the parenteral nutrition (PN), which aids in the long-term survival of the patients. Other treatment options include surgical lengthening, which is not sufficient in
Mahmoud Shaaban, Mohamed +2 more
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Aging of intestinal stem cells
Stem Cell Reports, 2022 The intestine is one of the organs that relies on stem cell function for maintaining tissue homeostasis. Recent findings on intestinal aging show that intestinal architecture, such as villus length, crypt size, and cell composition changes in the aged crypts.
Nalapareddy, Kodandaramireddy +2 more
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Plasticity of Paneth cells and their ability to regulate intestinal stem cells
Stem Cell Research & Therapy, 2020 Paneth cells (PCs) are located at the bottom of small intestinal crypts and play an important role in maintaining the stability of the intestinal tract.
Xianglin Mei, Ming Gu, Meiying Li
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