Expanding intestinal stem cells in culture [PDF]
Cell Research, 2015 Culturing intestinal stem cells into 3D organoids results in heterogeneous cell populations, reflecting the in vivo cell type diversity. In a recent paper published in Nature, Wang et al. established a culture condition for a highly homogeneous population of intestinal stem cells.
Inha, Heo, Hans, Clevers
openaire +3 more sources
Intestinal Stem Cells Exhibit Conditional Circadian Clock Function
Stem Cell Reports, 2018 Summary: The circadian clock is a molecular pacemaker that produces 24-hr physiological cycles known as circadian rhythms. How the clock regulates stem cells is an emerging area of research with many outstanding questions.
Kathyani Parasram +6 more
doaj +2 more sources
Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells [PDF]
Stem Cell Reports, 2015 The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cells intermingled with Paneth cells at the base of crypts.
Dustin J. Flanagan +15 more
doaj +2 more sources
Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]
, 2014 In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Raineteau, Olivier +17 more
core +1 more source
IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration
Nature Communications, 2023 The influence of aging on intestinal stem cells and their niche can explain underlying causes for perturbation in their function observed during aging.
Omid Omrani +16 more
doaj +1 more source
The Intestinal Stem Cell [PDF]
, 2010 The intestinal epithelium is one of the most rapidly proliferating organs in the body. A complete turnover of the epithelium occurs every 3-5 days in the mouse, a process that is maintained by a small population of intestinal stem cells (ISCs) that reside in the crypt bases. The signals that regulate the behavior of these ISCs are still unknown.
Luis A, Chia, Calvin J, Kuo
openaire +2 more sources
LGR5+ Intestinal Stem Cells Display Sex-Dependent Radiosensitivity
, 2023 Tissue radiosensitivity plays a critical role in the overall outcome of radiation therapy. Identifying characteristics that predict how a patient may respond to radiotherapy enables clinicians to maximize the therapeutic window.
Ryan C. Zitter +4 more
core +1 more source
Current Gastroenterology Reports, 2010 Self-renewal in the intestinal epithelia is fueled by a population of undifferentiated intestinal stem cells (ISCs) that give rise to daughter or progenitor cells, which can subsequently differentiate into the mature cell types required for normal gut function.
openaire +2 more sources
Identification, properties, and clinical significance of putative stem-like cell populations in prostate cancer [PDF]
, 2012 The notion that tumour initiation and heterogeneity might be driven by small population of tumour-initiating cells (TIC) has gained high significance since the pioneering identification of TIC in leukaemia.
Le Magnen, Clémentine
core +1 more source
Advances in Exploring the Interaction between Paneth Cells and Intestinal Stem Cells and Possible Targets for Traditional Chinese Medicine Based on Mitochondrial Function and Energy Metabolism [PDF]
Zhongguo quanke yixueIntestinal stem cells and Paneth cells interact with each other to maintain intestinal homeostasis and function, the interaction between intestinal stem cells and Paneth cells is regulated by mitochondria-related functions and energy conversion.
LUO Guoliang, ZHANG Xindan, TANG Taichun, ZHU Yan, WANG Shuting, CHEN Min
doaj +1 more source