Results 21 to 30 of about 128,505 (309)

Secretory Sorcery: Paneth Cell Control of Intestinal Repair and HomeostasisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Paneth cells are professional secretory cells that classically play a role in the innate immune system by secreting antimicrobial factors into the lumen to control enteric bacteria.
Paul Cray, Breanna J. Sheahan, Christopher M. Dekaney   +2 more
doaj   +1 more source

ID1 Is a Functional Marker for Intestinal Stem and Progenitor Cells Required for Normal Response to Injury

Stem Cell Reports, 2014
LGR5 and BMI1 mark intestinal stem cells in crypt base columnar cells and +4 position cells, respectively, but characterization of functional markers in these cell populations is limited.
Ning Zhang, Rhonda K. Yantiss, Hyung-song Nam, Yvette Chin, Xi Kathy Zhou, Ellen J. Scherl, Brian P. Bosworth, Kotha Subbaramaiah, Andrew J. Dannenberg, Robert Benezra   +9 more
doaj   +1 more source

Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation

Nature Communications, 2022
Intestinal stem cells are responsible for replenishing cells within the high-turnover intestinal epithelium. Here they show that ribosome dynamics affect intestinal stem cell identity through a mechanism that is triggered by changes in nutrient ...
Joana Silva, Ferhat Alkan, Sofia Ramalho, Goda Snieckute, Stefan Prekovic, Ana Krotenberg Garcia, Santiago Hernández-Pérez, Rob van der Kammen, Danielle Barnum, Liesbeth Hoekman, Maarten Altelaar, Wilbert Zwart, Saskia Jacoba Elisabeth Suijkerbuijk, Simon Bekker-Jensen, William James Faller   +14 more
doaj   +1 more source

Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA5-Dependent SignalingSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Regeneration of the epithelium by stem cells in the intestine is supported by intrinsic and extrinsic factors. Lysophosphatidic acid (LPA), a bioactive lipid mediator, regulates many cellular functions, including cell proliferation,
Zhongxing Liang, Peijian He, Yiran Han, C. Chris Yun   +3 more
doaj   +1 more source

Stem cell decisions:A twist of fate or a niche market? [PDF]

, 2014
Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Näthke, Inke, Nathke, Inke; id_orcid, Januschke, Jens, Januschke, Jens; id_orcid   +3 more
core   +1 more source

Progress of Research on Mechanism of Intestinal Nervous System Regulating Intestinal Inflammation Based on Intestinal Stem Cells [PDF]

Zhongguo quanke yixue
Intestinal stem cells are regulated by the intestinal nervous system, and both of them are closely related to intestinal inflammation. Relevant studies have shown the existence of intestinal nerve dysfunction in intestinal inflammation.
CHEN Siqi, XIAO Jin, TIAN Siyu, ZHANG Jia, WANG Shuting, ZHANG Xindan, ZHU Yan, CHEN Min
doaj   +1 more source

Paneth Cells and Lgr5⁺ Intestinal Stem Cells in Radiation Enteritis

Applied Sciences, 2023
Cancer is the leading cause of death in adults and majority of cancers involve abdominal and pelvic organs. Radiotherapy is used in the management of around half of patients who have abdominal and pelvic malignancies and 70% of the treated patients will ...
Thifhelimbilu Luvhengo, Uzayr Khan, Thomas Kekgatleope Marumo   +2 more
doaj   +1 more source

Intestinal Stem Cells in Mammals and Drosophila [PDF]

Cell Stem Cell, 2009
In the last few years, our knowledge of intestinal stem cell biology has flourished. Here we review recent developments in this exciting field, paying special attention to the characterization of Drosophila and mammalian intestinal stem cells.
Casali, Andreu, Batlle, Eduard
openaire   +2 more sources

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. [PDF]

, 2010
E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Trülzsch, Konrad, Eckhard Wolf, Sylvia Steininger, Hirschi Benjamin, Müller-Höcker Josef, Frank T Kolligs, Allgäuer, Michael, Marlon R. Schneider, Schneider Marlon R., Dahlhoff, Maik, Gerhard Markus, Schneider, Marlon R., Konrad Trülzsch, Vogelmann, Roger, Maik Dahlhoff, Müller-Höcker, Josef, Michael Allgäuer, Allgäuer Michael, Horst David, Roger Vogelmann, Markus Gerhard, Horst, David, Frank T. Kolligs, Wolf Eckhard, Dahlhoff Maik, Benjamin Hirschi, Kolligs, Frank T., David Horst, Trülzsch Konrad, Wolf, Eckhard, Josef Müller-Höcker, Kolligs Frank T., Marlon R Schneider, Hirschi, Benjamin, Steininger Sylvia, Gerhard, Markus, Steininger, Sylvia, Vogelmann Roger   +37 more
core   +1 more source

The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology

Biological Research, 2018
Background The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase enzymes tankyrase1 and 2. LGR5 is
Jens Henrik Norum, Ellen Skarpen, Andreas Brech, Raoul Kuiper, Jo Waaler, Stefan Krauss, Therese Sørlie   +6 more
doaj   +1 more source