Results 31 to 40 of about 128,505 (309)

Research progress on the role of prostaglandin E2 in promoting recovery of intestinal mucosal injury [PDF]

Xin yixue, 2022
Prostaglandin E2 （PGE2）, as a member of prostaglandin E, belongs to eicosanoids. It participates in inflammatory reaction and immune regulation. Under normal physiological conditions, intestinal mucosa undergoes persistent self-renewal.
Yue Mengzhen, Fan Hancheng, Zhu Qingxian, Zeng Huihong, Shao Lijian
doaj   +1 more source

ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer. [PDF]

PLoS ONE, 2015
Several studies have suggested ERBB3/HER3 may be a useful prognostic marker for colorectal cancer. Tumours with an intestinal stem cell signature have also been shown to be more aggressive. Here, we investigate whether ERBB3 is associated with intestinal
Thierry Jardé, Lisa Kass, Margaret Staples, Helen Lescesen, Peter Carne, Karen Oliva, Paul J McMurrick, Helen E Abud   +7 more
doaj   +1 more source

Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell NicheSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: Intestinal epithelial stem cells that express leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) and/or B cell specific Moloney murine leukemia virus integration site 1 (Bmi1) continuously replicate and generate ...
Reina Aoki, Michal Shoshkes-Carmel, Nan Gao, Soona Shin, Catherine L. May, Maria L. Golson, Adam M. Zahm, Michael Ray, Caroline L. Wiser, Christopher V.E. Wright, Klaus H. Kaestner   +10 more
doaj   +1 more source

Hallmarks of intestinal stem cells

Development, 2020
ABSTRACT Intestinal stem cells (ISCs) are highly proliferative cells that fuel the continuous renewal of the intestinal epithelium. Understanding their regulatory mechanisms during tissue homeostasis is key to delineating their roles in development and regeneration, as well as diseases such as bowel cancer and inflammatory bowel disease.
Anna, Baulies, Nikolaos, Angelis, Vivian S W, Li   +2 more
openaire   +2 more sources

Investigating the relation between Stochastic Differentiation, Homeostasis and Clonal Expansion in Intestinal Crypts via Multiscale Modeling [PDF]

, 2014
Colorectal tumors originate and develop within intestinal crypts. Even though some of the essential phenomena that characterize crypt structure and dynamics have been effectively described in the past, the relation between the differentiation process and
De Matteis Giovanni, De Matteis G, Graudenzi Alex, Caravagna Giulio, De Matteis, Giovanni, Antoniotti, Marco, Giulio Caravagna (380492), Graudenzi, Alex, Antoniotti M, Alex Graudenzi (569252), Graudenzi A, Caravagna G, Caravagna, Giulio, Marco Antoniotti, Giovanni De Matteis, Giovanni De Matteis (5659246), Giulio Caravagna, Antoniotti Marco, Alex Graudenzi, Marco Antoniotti (66901)   +19 more
core   +1 more source

Advances in Energy Metabolism Regulation of Intestinal Stem Cell Function and the Therapeutic Advantages of Traditional Chinese Medicine [PDF]

Zhongguo quanke yixue
Intestinal stem cells are an important part of maintaining the stability of intestinal barrier function, which is closely related to intestinal homeostasis, intestinal epithelial renewal, and repair of intestinal damage.
ZHU Yan, XIAO Jin, YANG Yang, TANG Taichun, WANG Shuting, CHEN Siqi, CHEN Min
doaj   +1 more source

Regulation of Intestinal Stem Cells [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2004
Stem cells are essential for maintaining the tissue integrity of all adult tissues. The manipulation of adult stem cells has the potential for cell regeneration and in curing diseases; however, the intestinal stem cell remains enigmatic. Although much work has focused on characterization of the intestinal stem cell within its in vivo niche, the lack of
openaire   +2 more sources

Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components

Stem Cells International, 2017
The intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of crypts and are constantly nourished by their surrounding niche for maintenance, self-renewal ...
Laween Meran, Anna Baulies, Vivian S. W. Li   +2 more
doaj   +1 more source

STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.

PLoS ONE, 2010
Intestinal stem cells play a pivotal role in the epithelial tissue renewal, homeostasis and cancer development. The lack of a general marker for intestinal stem cells across species has hampered analysis of stem cell number in different species and their
Zhengyuan Wang, Paul Matsudaira, Zhiyuan Gong   +2 more
doaj   +1 more source

Evolutionary insights into postembryonic development of adult intestinal stem cells

Cell & Bioscience, 2011
In the adult vertebrate intestine, multi-potent stem cells continuously generate all of the epithelial cells throughout the adulthood. While it has long been known that the frog intestine is formed via the development of adult intestinal stem cells ...
Ishizuya-Oka Atsuko, Shi Yun-Bo
doaj   +1 more source