Results 41 to 50 of about 128,505 (309)

Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome [PDF]

, 2020
The pathophysiology of irritable bowel syndrome (IBS) is not completely understood. However, several factors are known to play a role in pathophysiology of IBS such as genetics, diet, gut microbiota, gut endocrine cells, stress and low-grade inflammation.
El-Salhy, Magdy
core   +1 more source

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells [PDF]

, 2010
hESCs (human embryonic stem cells) offer great potential for pharmaceutical research and development and, potentially, for therapeutic use. However, improvements in cell culture are urgently required to allow the scalable production of large numbers of ...
Baillie, George S., Nicole M. Kane, Fergus R. McKenzie, Kane, N.M., Achamma Abraham, George S. Baillie, Allcock, R.W., John McAbney, Peter Burton, Baillie, G.S., Graeme Milligan, Kane, Nicole M., Houslay, Miles D., Andrew H. Baker, Robert W. Allcock, Gilmour, J., Gilmour, Jane, Mountford, Joanne C., Joanne C. Mountford, Jiang, Zhong, Miles D. Houslay, Adams, D.R., Adams, David R., McAbney, J., McCahill, Angela, Milligan, Graeme, McKenzie, F.R., Burton, Peter, Abraham, Achamma, Baker, Andrew H., McCahill, A., Jane Gilmour, Jiang, Z., Baker, A.H., Mountford, J.C., Angela McCahill, Abraham, A., Houslay, M.D., McAbney, John, McKenzie, Fergus R., Burton, P., David R. Adams, Milligan, G., Allcock, Robert W., Zhong Jiang   +44 more
core   +1 more source

Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary

Cellular and Molecular Gastroenterology and Hepatology
Intestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of
Michaela Quintero, Linda C. Samuelson
doaj   +1 more source

Intestinal stem cells promote crypt fission during postnatal growth of the small intestine

BMJ Open Gastroenterology, 2020
Objective Wnt-β-catenin signalling is essential for intestinal stem cells. Our aim was to investigate the relationship between intestinal stem cells and crypt fission which peaks during infancy.Design Duodenal biopsies were obtained during endoscopy to ...
Zenab Mustansir Dudhwala, Paul D Hammond, Gordon S Howarth, Adrian Gerard Cummins   +3 more
doaj   +1 more source

Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells

Stem Cell Research, 2015
Krüppel-like factor 5 (KLF5) is a pro-proliferative transcription factor that is expressed in dividing epithelial cells of the intestinal crypt. Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) has been identified as a stem cell marker ...
Mandayam O. Nandan, Amr M. Ghaleb, Agnieszka B. Bialkowska, Vincent W. Yang   +3 more
doaj   +1 more source

Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.

PLoS Genetics, 2021
The differentiation efficiency of adult stem cells undergoes a significant decline in aged animals, which is closely related to the decline in organ function and age-associated diseases.
Kun Wu, Yiming Tang, Qiaoqiao Zhang, Zhangpeng Zhuo, Xiao Sheng, Jingping Huang, Jie'er Ye, Xiaorong Li, Zhiming Liu, Haiyang Chen   +9 more
doaj   +1 more source

Sox100B Regulates Progenitor-Specific Gene Expression and Cell Differentiation in the Adult Drosophila Intestine

Stem Cell Reports, 2020
Summary: Robust production of terminally differentiated cells from self-renewing resident stem cells is essential to maintain proper tissue architecture and physiological functions, especially in high-turnover tissues.
Fanju W. Meng, Sebastian E. Rojas Villa, Benoît Biteau   +2 more
doaj   +1 more source

Intestinal Stem Cells: Got Calcium? [PDF]

Current Biology, 2016
Calcium ions are well-known intracellular signalling molecules. A new study identifies local cytoplasmic calcium as a central integrator of metabolic and proliferative signals in Drosophila intestinal stem cells.
Naszai, Mate, Cordero, Julia
openaire   +3 more sources

BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt 1 Viability after 2 Radiation [PDF]

, 2015
Blood vessel epicardial substance (BVES/Popdc1) is a junctional-associated transmembrane protein that is underexpressed in a number of malignancies and regulates epithelial-to-mesenchymal transition. We previously identified a role for BVES in regulation
Short, SP, Keatin, CE, Thompson, JJ, Harris, EI, Revetta, F, Bader, DM, Barrett, CW, Washington, MK, Mittal, MK, Reddy, VK, Williams, CS, Brand, T   +11 more
core   +1 more source

Protein arginine methyltransferase 1 regulates cell proliferation and differentiation in adult mouse adult intestine

Cell & Bioscience, 2021
Background Adult stem cells play an essential role in adult organ physiology and tissue repair and regeneration. While much has been learnt about the property and function of various adult stem cells, the mechanisms of their development remain poorly ...
Lu Xue, Lingyu Bao, Julia Roediger, Yijun Su, Bingyin Shi, Yun-Bo Shi   +5 more
doaj   +1 more source