Results 61 to 70 of about 3,117 (204)

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, Volume 15, Issue 9, 6 March 2026.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

Additional file 2 of Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics

, 2021
Additional file 2. HE image of equine enteroids. HE stained section of equine enteroids at day 7 of culture.
Stina Hellman (11282114)
core   +1 more source

Using primary murine intestinal enteroids to study dietary TAG absorption, lipoprotein synthesis, and the role of apoC-III in the intestine[S]

Journal of Lipid Research, 2017
Since its initial report in 2009, the intestinal enteroid culture system has been a powerful tool used to study stem cell biology and development in the gastrointestinal tract. However, a major question is whether enteroids retain intestinal function and
Javeed Jattan, Cayla Rodia, Diana Li, Adama Diakhate, Hongli Dong, Amy Bataille, Noah F. Shroyer, Alison B. Kohan   +7 more
doaj   +1 more source

Bioelectronic Technology for Nutritional Research—a Novel In Vitro Platform for a Better Understanding of Human Gut Barrier Absorption

Advanced Biology, Volume 10, Issue 2, February 2026.
This is the first study to demonstrate that the e‐transmembrane gut model provides more accurate physiological predictions than conventional cell culture inserts when tested by the dietary compound butyrate. The bioelectronic e‐transmembrane platform integrates technological and biological optimizations, enabling the hosting of a complex human gut in ...
Verena Stoeger, Magdalena Strauss, Kumar Thurimella, Shani Elias‐Kirma, Izabella Niewczas, Etkin Parlar, Erika Schaudy, Chrysanthi‐Maria Moysidou, Stephen Voong, Jory Lietard, Jonathan Clark, Christopher Gerner, Róisín M. Owens   +12 more
wiley   +1 more source

Image_5_Human Intestinal Enteroids Model MHC-II in the Gut Epithelium.JPEG

, 2019
The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, “mini-guts” derived from small intestinal crypt stem cells, and show ...
Jonathan E. Wosen (7280258), Manuel R. Amieva (7280267), Nielsen Q. Fernandez-Becker (6001403), Elizabeth D. Mellins (7280270), Calvin J. Kuo (7280264), Julia Y. Co (5964173), Alexandra Ilstad-Minnihan (4385836), Wei Jiang (14986), Dhriti Mukhopadhyay (7280261)   +8 more
core   +1 more source

Reuterin disrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation

Gut Microbes, 2020
Antibiotic resistance is one of the world’s greatest public health challenges and adjunct probiotic therapies are strategies that could lessen this burden.
Melinda A. Engevik, Heather A. Danhof, Ritu Shrestha, Alexandra L. Chang-Graham, Joseph M. Hyser, Anthony M. Haag, Mahmoud A. Mohammad, Robert A. Britton, James Versalovic, Joseph A. Sorg, Jennifer K. Spinler   +10 more
doaj   +1 more source

Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure

Toxins, 2020
The different effects of deoxynivalenol (DON) on intestinal barrier and stem cells by its route of exposure remain less known. We explored the toxic effects of DON on intestinal barrier functions and stem cells after DON microinjection (luminal exposure)
Hikaru Hanyu, Yuki Yokoi, Kiminori Nakamura, Tokiyoshi Ayabe, Keisuke Tanaka, Kinuko Uno, Katsuhiro Miyajima, Yuki Saito, Ken Iwatsuki, Makoto Shimizu, Miki Tadaishi, Kazuo Kobayashi-Hattori   +11 more
doaj   +1 more source

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Advanced Healthcare Materials, Volume 15, Issue 8, 23 February 2026.
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers   +10 more
wiley   +1 more source

Image_1_Human Intestinal Enteroids Model MHC-II in the Gut Epithelium.JPEG

, 2019
The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, “mini-guts” derived from small intestinal crypt stem cells, and show ...
Jonathan E. Wosen (7280258), Manuel R. Amieva (7280267), Nielsen Q. Fernandez-Becker (6001403), Elizabeth D. Mellins (7280270), Calvin J. Kuo (7280264), Julia Y. Co (5964173), Alexandra Ilstad-Minnihan (4385836), Wei Jiang (14986), Dhriti Mukhopadhyay (7280261)   +8 more
core   +1 more source

Exploring microorganism–host interactions: Emerging organoid models and analytical approaches

mLife, Volume 5, Issue 1, Page 17-34, February 2026.
Abstract Microorganisms play a vital role in human health through their interactions with the body. Studies of host–microbe mechanisms and interactions are crucial for advancing health management. Recently, the organoid‐based models have provided new platforms in this field.
Yue Shi, Min Xu, Yanhong Huang, Jing Qu, Shumin Liao, Yingzi Liu, Liang Li   +6 more
wiley   +1 more source