LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]
, 2018 Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R +8 more
core +2 more sources
Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals
Frontiers in Immunology, 2021 Interleukin 10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective role in the intestine. Although its production by cells of the innate and adaptive immune system has been extensively studied, its intrinsic role in ...
Stamatia Papoutsopoulou +15 more
doaj +1 more source
Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model [PDF]
Infection and Immunity, 2019 The enteric pathogen Shigella is one of the leading causes of moderate-to-severe diarrhea and death in young children in developing countries. Transformed cell lines and animal models have been widely used to study Shigella pathogenesis.
Ranganathan, Sridevi +5 more
openaire +2 more sources
Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions [PDF]
, 2017 Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries.
Begum, Yasmin Ara +7 more
core +3 more sources
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis [PDF]
Journal of Visualized Experiments, 2019 Necrotizing enterocolitis (NEC) is a devastating disease of newborn infants. It is characterized by multiple pathophysiologic alterations in the human intestinal epithelium, leading to increased intestinal permeability, impaired restitution, and increased cell death.
Guillermo J, Ares +4 more
openaire +2 more sources
Dasabuvir inhibits human norovirus infection in human intestinal enteroids [PDF]
mSphere, 2021 Abstract Human noroviruses (HuNoVs) are acute viral gastroenteritis pathogens that affect all age groups, yet no approved vaccines and drugs to treat HuNoV infection are available. In this study, with a human intestinal enteroid (HIE) culture system where HuNoVs are able to replicate reproducibly, we screened an antiviral compound ...
Tsuyoshi Hayashi +8 more
openaire +3 more sources
Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3
Frontiers in Cellular and Infection Microbiology, 2021 Human parechovirus (PeV-A), one of the species within the Picornaviridae family, is known to cause disease in humans. The most commonly detected genotypes are PeV-A1, associated with mild gastrointestinal disease in young children, and PeV-A3, linked to ...
Inés García-Rodríguez +8 more
doaj +1 more source
Cre-Recombinase Induces Apoptosis and Cell Death in Enterocyte Organoids
Antioxidants, 2022 The culture of primary intestinal epithelia cells is not possible in a normal culture system. In 2009 a three-dimensional culture system of intestinal stem cells was established that shows many of the physiological features of the small intestine, such ...
Franziska Moll +2 more
doaj +1 more source
Antioxidants, 2023 Necrotizing enterocolitis (NEC) is a neonatal intestinal disease associated with oxidative stress. The targets of peroxidation and the role of the innate intestinal epithelial antioxidant defense system are ill-defined.
Alena Golubkova +9 more
doaj +1 more source
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]
, 2013 Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D +6 more
core +2 more sources