Results 31 to 40 of about 274,446 (288)

Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease

Frontiers in Medicine, 2021
Inflammatory bowel disease describes chronic inflammatory disorders. The incidence of the disease is rising. A major step in disease development is the breakdown of the epithelial cell barrier.
Michael Stürzl, Meik Kunz, Susanne M. Krug, Elisabeth Naschberger   +3 more
doaj   +1 more source

IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. [PDF]

, 2022
OBJECTIVE Disruption of the epithelial barrier plays an essential role in developing eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated food-associated and aeroallergen-associated chronic inflammation.
Wuggenig, Philipp, Sandro Nuciforo, Noti, Mario, Petr Hruz, Kaymak, Tanay, Andreas Göldi, Kaya, Berna, Jan Hendrik Niess, Niess, Jan Hendrik, Berna Kaya, Tanay Kaymak, Melhem, Hassan, Julien Roux, Oswald, Franz, Hruz, Petr, Hassan Melhem, Philipp Wuggenig, Mario Noti, Nuciforo, Sandro, Göldi, Andreas, Franz Oswald, Roux, Julien   +21 more
core   +1 more source

Microbiome Composition and Circadian Rhythm Disruption Alters Epithelial Barrier Integrity

, 2021
The intestine is home to one of the most complex ecological communities, termed the human gut microbiome. The gut microbiome modulates a wide range of human diseases from diabetes to neurological disorders to cancer.
Pinker, Elisha, Tuganbaev, Timur
core   +3 more sources

Acinetobacter baumannii Outer Membrane Protein A Induces Pulmonary Epithelial Barrier Dysfunction and Bacterial Translocation Through The TLR2/IQGAP1 Axis

Frontiers in Immunology, 2022
Pulmonary epithelial barrier dysfunction is a critical pathophysiological process in pneumonia and associated invasive infections, such as those caused by Acinetobacter baumannii. However, the mechanisms underlying A.
Wang Zhang, Wang Zhang, Wang Zhang, Hua Zhou, Yan Jiang, Yan Jiang, Yan Jiang, Jintao He, Jintao He, Jintao He, Yue Yao, Yue Yao, Yue Yao, Jianfeng Wang, Xiaochen Liu, Xiaochen Liu, Xiaochen Liu, Sebastian Leptihn, Sebastian Leptihn, Sebastian Leptihn, Xiaoting Hua, Xiaoting Hua, Xiaoting Hua, Yunsong Yu, Yunsong Yu, Yunsong Yu   +25 more
doaj   +1 more source

Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitis [PDF]

, 2017
BACKGROUND Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated disease characterized by symptoms related to esophageal dysfunction and an eosinophil-predominant inflammation.
Straumann, Alex, B. Page, Blanchard, C, Simon, H-U, Straumann, A, Vogel, Monique, D. Simon, Page, B, Page, Basile, A. Straumann, Simon, Hans-Uwe, Bussmann, C, M. Vogel, H.‐U. Simon, Vogel, M, Blanchard, Carine, Simon, D; https://orcid.org/, Bussmann, Christian, C. Bussmann, Simon, Dagmar, C. Blanchard   +20 more
core   +1 more source

Porphyromonas gingivalis Infection Induces Lipopolysaccharide and Peptidoglycan Penetration Through Gingival Epithelium

Frontiers in Oral Health, 2022
Periodontal diseases initiate on epithelial surfaces of the subgingival compartment, while the gingival epithelium functions as an epithelial barrier against microbial infection and orchestrates immune responses.
Hiroki Takeuchi, Eriko Nakamura, Shunsuke Yamaga, Atsuo Amano   +3 more
doaj   +1 more source

Airway epithelial barrier function regulates the pathogenesis of allergic asthma [PDF]

, 2014
The integrity of the airway epithelium in patients with asthma is often disrupted, with loss of epithelial cell-cell contacts. Airway epithelial barrier dysfunction may have important implications for asthma, because structural epithelial barrier ...
Heijink, I. H., Hackett, T. -L., Nawijn, M. C.; id_orcid, Nawijn, M. C.   +3 more
core   +1 more source

Microbial products induce claudin-2 to compromise gut epithelial barrier function. [PDF]

PLoS ONE, 2013
The epithelial barrier dysfunction is an important pathogenic feature in a number of diseases. The underlying mechanism is to be further investigated.
Xiaoyu Liu, Gui Yang, Xiao-Rui Geng, Yanjuan Cao, Na Li, Li Ma, Si Chen, Ping-Chang Yang, Zhigang Liu   +8 more
doaj   +1 more source

The Epithelial Barrier

, 2019
The intestinal epithelium serves as the first line of defense against pathogens in the gut. Breakdown of the epithelial barrier is a hallmark of inflammatory bowel diseases, in which epithelial dysfunction leads to a fulminant immune response to luminal antigens.
Escudero-Hernández, Celia, Koch, Stefan
openaire   +1 more source

The impact of aging on epithelial barriers [PDF]

Tissue Barriers, 2017
The epithelium has many critical roles in homeostasis, including an essential responsibility in establishing tissue barriers. In addition to the fundamental role in separating internal from external environment, epithelial barriers maintain nutrient, fluid, electrolyte and metabolic waste balance in multiple organs.
openaire   +2 more sources