Results 51 to 60 of about 274,446 (288)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Epithelial barrier hypothesis and the development of allergic and autoimmune diseases [PDF]

, 2022
The “epithelial barrier hypothesis” proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial barrier–damaging agents and chronic periepithelial inflammation are responsible for the development of allergic and ...
Wallimann, Alexandra; https://orcid.org/, Wawrocki, Sebastian, Ogulur, Ismail; https://orcid.org/, Akdis, Mübeccel; https://orcid.org/, Pat, Yagiz; https://orcid.org/, Li, Manru, Küçükkase, Ozan; https://orcid.org/, Sackesen, Cansin, Çelebi Sözener, Zeynep, Buyuktiryaki, Betul, Yazici, Duygu; https://orcid.org/, Rinaldi, Arturo O; https://orcid.org/, Mitamura, Yasutaka; https://orcid.org/, Akdis, Cezmi A; https://orcid.org/   +13 more
core   +1 more source

Novel Food Supplement Containing a Combination of Postbiotics and Plant-Derived Compounds Regulates Epithelial Barrier Integrity and Immune Response in Human Enterocytes

Foods
Background: Alterations of epithelial barrier integrity and immune response play a key role in the pathogenesis of allergic diseases and represent promising targets for nutritional interventions. Selected postbiotics and plant-derived compounds have been
Franca Oglio, Serena Coppola, Alessia Cadavere, Roberta Di Santillo, Vittoria Mauriello, Marco Michelini, Raffaele Federico Iorio, Erika Caldaria, Laura Carucci   +8 more
doaj   +1 more source

The role and mechanisms of gingival epithelial cells in maintaining periodontal homeostasis [PDF]

口腔疾病防治
Periodontal homeostasis is regulated by the complex interplay between the gingival epithelial barrier, the extracellular matrix of soft tissues, the bone coupling system, and immune responses within the periodontal region.
WANG Xiao, WU Yajie, SU Zhifei, LI Jiyao
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

CaMKII regulates the strength of the epithelial barrier [PDF]

Scientific Reports, 2015
AbstractEpithelial cells define the boundary between the outside and the inside of our body by constructing the diffusion barrier. Tight junctions (TJs) of epithelial cells function as barriers against invasion of harmful microorganisms into the human body and free diffusion of water or ions from the body. Therefore, formation of TJs has to be strictly
Ryo Shiomi, Kenta Shigetomi, Tetsuichiro Inai, Masami Sakai, Junichi Ikenouchi   +4 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Protects Porcine Intestinal Barrier from Deoxynivalenol via Improved Zonula Occludens-1 Expression [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
Intestinal epithelial cells (IECs) forming the barrier for the first-line of protection are interconnected by tight junction (TJ) proteins. TJ alteration results in impaired barrier function, which causes potentially excessive inflammation leading to ...
Min Jeong Gu, Sun Kwang Song, Sung Moo Park, In Kyu Lee, Cheol-Heui Yun   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source