Results 31 to 40 of about 412,031 (297)

Disruption of Claudin-Made Tight Junction Barriers by Clostridium perfringens Enterotoxin: Insights from Structural Biology

Cells, 2022
Claudins are a family of integral membrane proteins that enable epithelial cell/cell interactions by localizing to and driving the formation of tight junctions.
Chinemerem P. Ogbu, Sourav Roy, Alex J. Vecchio   +2 more
doaj   +1 more source

The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell—Cell Junctions of Epithelial Cells

Cells, 2022
Transmembrane proteins of adherens and tight junctions are known targets for viruses and bacterial toxins. The coronavirus receptor ACE2 has been localized at the apical surface of epithelial cells, but it is not clear whether ACE2 is localized at apical
Florian Rouaud, Isabelle Méan, Sandra Citi   +2 more
doaj   +1 more source

Listeria monocytogenes invades the epithelial junctions at sites of cell extrusion. [PDF]

PLoS Pathogens, 2006
Listeria monocytogenes causes invasive disease by crossing the intestinal epithelial barrier. This process depends on the interaction between the bacterial surface protein Internalin A and the host protein E-cadherin, located below the epithelial tight ...
Mickey Pentecost, Glen Otto, Julie A Theriot, Manuel R Amieva   +3 more
doaj   +2 more sources

Cell–Cell Interaction Proteins (Gap Junctions, Tight Junctions, and Desmosomes) and Water Transporter Aquaporin 4 in Meningothelial Cells of the Human Optic Nerve

Frontiers in Neurology, 2017
PurposeMeningothelial cells (MECs) play a central role in the maintenance of cerebrospinal fluid (CSF) homeostasis and in physiological and pathophysiological processes within the subarachnoid space (SAS) linking them to optic nerve (ON) pathologies ...
Thi Ngoc Co Zeleny, Corina Kohler, Corina Kohler, Albert Neutzner, Albert Neutzner, Hanspeter E. Killer, Hanspeter E. Killer, Peter Meyer, Peter Meyer   +8 more
doaj   +1 more source

Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown [PDF]

, 2010
Background: An inducible release of soluble junctional adhesion molecule-A (sJAM-A) under pro-inflammatory conditions was described in cultured non-CNS endothelial cells (EC) and increased sJAM-A serum levels were found to indicate inflammation in non ...
Romero, Ignacio, Deiß Annika, Deiß, Annika, Buttmann, Mathias, Weksler Babette, Rieckmann, Peter, Ignacio Romero, Mathias Buttmann, Prochaska, Jürgen, Couraud, Pierre-Olivier, Jürgen Prochaska, Haarmann, Axel, Peter Rieckmann, Buttmann Mathias, Weksler, Babette, Axel Haarmann, Stoll, Guido, Najbauer, Joseph, Pierre-Olivier Couraud, Annika Deiss, Couraud Pierre-Olivier, Prochaska, Juergen, Stoll Guido, Guido Stoll, Förch, Christian, Romero Ignacio, Foerch, Christian, Prochaska Jürgen, Christian Foerch, Rieckmann Peter, Babette Weksler, Foerch Christian, Haarmann Axel   +32 more
core   +1 more source

The role of endothelial junctions in the regulation of the extravasation of tumor cells. A historical reappraisal

Frontiers in Oncology
Endothelial cells lining the vessel wall are connected by adherent, tight and gap junctions. Adherent junctions are common to all endothelial cells, whereas tight and gap junctions graduate within different vascular segments.
Domenico Ribatti
doaj   +1 more source

Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA

Gut Pathogens, 2019
Campylobacter jejuni secretes HtrA (high temperature requirement protein A), a serine protease that is involved in virulence. Here, we investigated the interaction of HtrA with the host protein occludin, a tight junction strand component ...
Aileen Harrer, Roland Bücker, Manja Boehm, Urszula Zarzecka, Nicole Tegtmeyer, Heinrich Sticht, Jörg D. Schulzke, Steffen Backert   +7 more
doaj   +1 more source

YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation. [PDF]

PLoS ONE, 2012
Tissue development and organ growth require constant remodeling of cell-cell contacts formed between epithelial cells. The Hippo signaling cascade curtails organ growth by excluding the transcriptional co-activator Yes Associated Protein 1 (YAP1) from ...
Kassiani Skouloudaki, Gerd Walz
doaj   +1 more source

SnapShot: Epithelial Tight Junctions [PDF]

, 2014
Tight junctions form a morphological and functional border between the apical and basolateral cell surface domains that serves as a paracellular diffusion barrier, enabling epithelial cells to separate compartments of different composition.
Matter, Karl, Balda, Maria S.
core   +1 more source

Effect of cAMP derivates on assembly and maintenance of tight junctions in human umbilical vein endothelial cells

BMC Cell Biology, 2010
Background Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on
Beese Michaela, Wyss Kristin, Haubitz Marion, Kirsch Torsten   +3 more
doaj   +1 more source