The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB [PDF]
, 2006 The tight junction adaptor protein ZO-1 regulates intracellular signaling and cell proliferation. Its Src homology 3 (SH3) domain is required for the regulation of proliferation and binds to the Y-box transcription factor ZO-1-associated nucleic acid ...
Balda, MS, Matter, K, Tsapara, A
core
Pathophysiology of tight junctions in human diseases. [PDF]
, 2016 The human body maintains maximal independence from the environment by means of a highly impermeable continuous cell sheet. For the maintenance of homeostasis, tight junctions must strictly regulate or restrict the passage of various solutes through the ...
澤田, 典均
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin [PDF]
, 2006 Epithelial tight junctions participate in the regulation of gene expression by controlling the activity of transcription factors that can interact with junctional components.
Choquet, A +6 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
"Barrierology" : Tight Junctions and Human Diseases [PDF]
, 2003 Tight junctions are intercellular junctions adjacent to the lateral end of the apical membrane. They have two functions: the barrier （or gate） function and the fence function.
小海, 康夫 +4 more
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Rol de las uniones estrechas del epitelio intestinal en la patogenia de la enfermedad de Crohn
Anales de la Facultad de Medicina, 2015 Crohn’s disease is an inflammatory bowel disease that affects the intestinal wall. This wall consists of an epithelial cell layer that forms a continuous polarized monolayer, closely connected by various types of cellular junctions.
Dionisio Díaz +3 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Analysis of Rho GTPase signalling pathways regulating epithelial morphogenesis [PDF]
, 2010 Rho GTPases are molecular switches controlling many aspects of cell behaviour, including cell cycle progression, cell division, migration and morphology. The activity of Rho proteins is regulated by conformational changes induced by binding of guanine
Wallace, S.
core
Sub-micron thin film intrinsic Josephson junctions [PDF]
, 2003 We have fabricated sub-micron intrinsic Josephson junctions in thin films of Tl-Ba-Ca-Cu-O using two differing techniques suited to different applications. By using lateral focussed ion-beam milling we have created arrays of intrinsic junctions in c-axis
Grovenor, CRM +9 more
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