Microglia in Circumventricular Organs: The Pineal Gland Example [PDF]
ASN Neuro, 2022 The circumventricular organs (CVOs) are unique areas within the central nervous system. They serve as a portal for the rest of the body and, as such, lack a blood-brain barrier.
Estela M. Muñoz
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ACE2, Circumventricular Organs and the Hypothalamus, and COVID-19 [PDF]
NeuroMolecular Medicine, 2022 The SARS-CoV-2 virus gains entry to cells by binding to angiotensin-converting enzyme 2 (ACE2). Since circumventricular organs and parts of the hypothalamus lack a blood-brain barrier, and immunohistochemical studies demonstrate that ACE2 is highly expressed in circumventricular organs which are intimately connected to the hypothalamus, and the ...
Wei-Yi Ong, Deron R Herr, Ong Wei-Yi
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Glial functions in the blood-brain communication at the circumventricular organs [PDF]
Frontiers in Neuroscience, 2022 The circumventricular organs (CVOs) are located around the brain ventricles, lack a blood-brain barrier (BBB) and sense blood-derived molecules. This review discusses recent advances in the importance of CVO functions, especially glial cells transferring
Seiji Miyata
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Sensory Circumventricular Organs, Neuroendocrine Control, and Metabolic Regulation [PDF]
Metabolites, 2021 The central nervous system is critical in metabolic regulation, and accumulating evidence points to a distributed network of brain regions involved in energy homeostasis.
Jin Kwon Jeong +2 more
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Circumventricular Organs and Parasite Neurotropism: Neglected Gates to the Brain? [PDF]
Frontiers in Immunology, 2018 Circumventricular organs (CVOs), neural structures located around the third and fourth ventricles, harbor, similarly to the choroid plexus, vessels devoid of a blood-brain barrier (BBB).
Marina Bentivoglio +2 more
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Development of Circumventricular Organs in the Mirror of Zebrafish Enhancer-Trap Transgenics [PDF]
Frontiers in Neuroanatomy, 2017 The circumventricular organs (CVOs) are small structures lining the cavities of brain ventricular system. They are associated with the semitransparent regions of the blood-brain barrier (BBB).
Marta García-Lecea +11 more
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Survodutide acts through circumventricular organs in the brain and activates neuronal regions associated with appetite regulation [PDF]
Molecular MetabolismSurvodutide is a novel GCG/GLP-1 receptor (GCGR/GLP-1R) dual agonist in clinical development for people with obesity and people with metabolic dysfunction-associated steatohepatitis (MASH).
Tina Zimmermann +15 more
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Permeability of the windows of the brain: feasibility of dynamic contrast-enhanced MRI of the circumventricular organs [PDF]
Fluids and Barriers of the CNS, 2020 Background Circumventricular organs (CVOs) are small structures without a blood–brain barrier surrounding the brain ventricles that serve homeostasic functions and facilitate communication between the blood, cerebrospinal fluid and brain.
Inge C. M. Verheggen +6 more
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Gadofluorine M-enhanced MRI shows involvement of circumventricular organs in neuroinflammation [PDF]
Journal of Neuroinflammation, 2010 Background Circumventricular organs (CVO) are cerebral areas with incomplete endothelial blood-brain barrier (BBB) and therefore regarded as "gates to the brain".
Glumm Robert +3 more
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Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging [PDF]
Frontiers in Aging NeuroscienceEffective communication between the brain and peripheral tissues is crucial for homeostasis and health, and its impairment is a defining feature of aging. Circumventricular organs, characterized by the presence of fenestrated capillaries and absence of a
Viana Q. Pham +6 more
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