Results 1 to 10 of about 385,110 (187)

Microglia in Circumventricular Organs: The Pineal Gland Example [PDF]

ASN Neuro, 2022
The circumventricular organs (CVOs) are unique areas within the central nervous system. They serve as a portal for the rest of the body and, as such, lack a blood-brain barrier.
Estela M. Muñoz
doaj   +7 more sources

Sensory Circumventricular Organs, Neuroendocrine Control, and Metabolic Regulation [PDF]

Metabolites, 2021
The central nervous system is critical in metabolic regulation, and accumulating evidence points to a distributed network of brain regions involved in energy homeostasis.
Jin Kwon Jeong, Samantha A. Dow, Colin N. Young   +2 more
doaj   +3 more sources

Development of Circumventricular Organs in the Mirror of Zebrafish Enhancer-Trap Transgenics [PDF]

Frontiers in Neuroanatomy, 2017
The circumventricular organs (CVOs) are small structures lining the cavities of brain ventricular system. They are associated with the semitransparent regions of the blood-brain barrier (BBB).
Marta García-Lecea, Marta García-Lecea, Evgeny Gasanov, Justyna Jedrychowska, Justyna Jedrychowska, Igor Kondrychyn, Igor Kondrychyn, Cathleen Teh, May-Su You, May-Su You, Vladimir Korzh, Vladimir Korzh   +11 more
doaj   +6 more sources

Circumventricular Organs and Parasite Neurotropism: Neglected Gates to the Brain? [PDF]

Frontiers in Immunology, 2018
Circumventricular organs (CVOs), neural structures located around the third and fourth ventricles, harbor, similarly to the choroid plexus, vessels devoid of a blood-brain barrier (BBB).
Marina Bentivoglio, Krister Kristensson, Martin E. Rottenberg   +2 more
doaj   +4 more sources

Toll-like receptor 4 agonist and antagonist lipopolysaccharides modify innate immune response in rat brain circumventricular organs [PDF]

Journal of Neuroinflammation, 2020
Background The circumventricular organs (CVOs) are blood-brain-barrier missing structures whose activation through lipopolysaccharide (LPS) is a starting point for TLR-driven (Toll-like receptors) neuroinflammation.
Alejandra Vargas-Caraveo, Aline Sayd, Javier Robledo-Montaña, Javier R. Caso, José L. M. Madrigal, Borja García-Bueno, Juan C. Leza   +6 more
doaj   +3 more sources

Permeability of the windows of the brain: feasibility of dynamic contrast-enhanced MRI of the circumventricular organs [PDF]

Fluids and Barriers of the CNS, 2020
Background Circumventricular organs (CVOs) are small structures without a blood–brain barrier surrounding the brain ventricles that serve homeostasic functions and facilitate communication between the blood, cerebrospinal fluid and brain.
Inge C. M. Verheggen, Joost J. A. de Jong, Martin P. J. van Boxtel, Alida A. Postma, Frans R. J. Verhey, Jacobus F. A. Jansen, Walter H. Backes   +6 more
doaj   +4 more sources

Gadofluorine M-enhanced MRI shows involvement of circumventricular organs in neuroinflammation [PDF]

Journal of Neuroinflammation, 2010
Background Circumventricular organs (CVO) are cerebral areas with incomplete endothelial blood-brain barrier (BBB) and therefore regarded as "gates to the brain".
Glumm Robert, Infante-Duarte Carmen, Wuerfel Eva, Wuerfel Jens T   +3 more
doaj   +4 more sources

Glial functions in the blood-brain communication at the circumventricular organs [PDF]

Frontiers in Neuroscience, 2022
The circumventricular organs (CVOs) are located around the brain ventricles, lack a blood-brain barrier (BBB) and sense blood-derived molecules. This review discusses recent advances in the importance of CVO functions, especially glial cells transferring
Seiji Miyata
doaj   +2 more sources

ACE2, Circumventricular Organs and the Hypothalamus, and COVID-19. [PDF]

Neuromolecular Med, 2022
The SARS-CoV-2 virus gains entry to cells by binding to angiotensin-converting enzyme 2 (ACE2). Since circumventricular organs and parts of the hypothalamus lack a blood-brain barrier, and immunohistochemical studies demonstrate that ACE2 is highly expressed in circumventricular organs which are intimately connected to the hypothalamus, and the ...
Ong WY, Satish RL, Herr DR.
europepmc   +3 more sources

Survodutide acts through circumventricular organs in the brain and activates neuronal regions associated with appetite regulation [PDF]

Molecular Metabolism
Survodutide is a novel GCG/GLP-1 receptor (GCGR/GLP-1R) dual agonist in clinical development for people with obesity and people with metabolic dysfunction-associated steatohepatitis (MASH).
Tina Zimmermann, Katherin Bleymehl, Peter Haebel, Johanna Perens, Urmas Roostalu, Jacob Hecksher-Sørensen, Jonas Doerr, Sebastian Jarosch, Daniel Lam, Holger Klein, Anton Pekcec, Samar N. Chehimi, Richard C. Crist, Benjamin C. Reiner, Matthew R. Hayes, Robert Augustin   +15 more
doaj   +2 more sources