SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability [PDF]
Nature Communications, 2023 Innervation of the hypothalamic median eminence by Gonadotropin-Releasing Hormone (GnRH) neurons is vital to ensure puberty onset and successful reproduction.
Antonella Lettieri +17 more
doaj +9 more sources
MCH Neurons Regulate Permeability of the Median Eminence Barrier [PDF]
Neuron, 2020 Melanin-concentrating hormone (MCH)-expressing neurons are key regulators of energy and glucose homeostasis. Here, we demonstrate that they provide dense projections to the median eminence (ME) in close proximity to tanycytes and fenestrated vessels. Chemogenetic activation of MCH neurons as well as optogenetic stimulation of their projections in the ...
Sarah Gallet +2 more
exaly +8 more sources
Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain [PDF]
JCI Insight, 2023 Central integration of peripheral appetite-regulating signals ensures maintenance of energy homeostasis. Thus, plasticity of circulating molecule access to neuronal circuits involved in feeding behavior plays a key role in the adaptive response to ...
Nicola Romanò +7 more
doaj +3 more sources
Cell Reports, 2021 Summary: The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy balance.
Sara Köhnke +2 more
exaly +4 more sources
Dietary fats promote functional and structural changes in the median eminence blood/spinal fluid interface—the protective role for BDNF [PDF]
Journal of Neuroinflammation, 2018 Background The consumption of large amounts of dietary fats activates an inflammatory response in the hypothalamus, damaging key neurons involved in the regulation of caloric intake and energy expenditure.
Albina F. Ramalho +8 more
doaj +3 more sources
Median eminence myelin continuously turns over in adult mice [PDF]
Molecular Metabolism, 2023 Objective: Oligodendrocyte progenitor cell differentiation is regulated by nutritional signals in the adult median eminence (ME), but the consequences on local myelination are unknown. The aim of this study was to characterize myelin plasticity in the ME
Sophie Buller +5 more
doaj +2 more sources
Changes in median eminence of fatty acid–binding protein 3 in a mouse model of pain [PDF]
Neuropsychopharmacology Reports, 2022 Aims Fatty acid–binding protein (FABP) regulates polyunsaturated fatty acid (PUFA) intracellular trafficking and signal transduction. Our previous studies demonstrated that the alteration of PUFA in the hypothalamus is involved in pain process.
Dan Tachibana +2 more
doaj +2 more sources
The Properties and Functions of Glial Cell Types of the Hypothalamic Median Eminence [PDF]
Frontiers in Endocrinology, 2022 The median eminence (ME) is part of the neuroendocrine system (NES) that functions as a crucial interface between the hypothalamus and pituitary gland.
Richard W. Clayton +2 more
doaj +2 more sources
A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction [PDF]
Frontiers in Molecular Neuroscience, 2022 The excitatory action of gamma-aminobutyric-acid (GABA) in the median-eminence (ME) led to the steady-state release of corticotropin-releasing hormone (CRH) from CRH axon terminals, which modulates the hypothalamic-pituitary-adrenal (HPA) axis.
Ruksana Yesmin +6 more
doaj +2 more sources
A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release via the Endocannabinoid System [PDF]
iScience, 2020 Summary: Based on the type-I cannabinoid receptor (CB1) content of hypophysiotropic axons and the involvement of tanycytes in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis, we hypothesized that endocannabinoids are involved in the ...
Erzsébet Farkas +25 more
doaj +2 more sources